MSP-1 Antibody (PVM-3): sc-52082

MSP-1 Antibody (PVM-3) is a mouse monoclonal IgG2b antibody that detects MSP-1 protein of Plasmodium vivax origin by western blotting (WB). MSP-1, or merozoite surface protein 1, plays a crucial role in the life cycle of the malaria parasite, particularly during the blood-stage infection when MSP-1 is a major surface component of the merozoite. MSP-1 is essential for the invasion of erythrocytes, as MSP-1 undergoes selective proteolytic processing and reassembly to facilitate the parasite′s entry into red blood cells. The glycosylphosphatidylinositol (GPI) anchor that links MSP-1 to the parasite plasma membrane is vital for MSP-1 function, as GPI ensures proper localization and stability on the surface of the merozoite. Additionally, MSP-1 is modified by post-translational glycosylation, with mono- or oligosaccharides attached via O-linkage to serines or threonines, and N-linked carbohydrates associated with asparagines, despite the absence of N-glycosylating machinery in Plasmodium falciparum. These modifications are important for MSP-1′s immunogenicity and ability to elicit a robust immune response, making MSP-1 a promising candidate for malaria vaccine development. Anti-MSP-1 antibody (PVM-3) is therefore an invaluable tool for researchers studying malaria pathogenesis and vaccine strategies.