BoNT/D Antibody (KB23): sc-51780

BoNT/D Antibody (KB23) is a mouse monoclonal IgG1 antibody that detects BoNT/D in Clostridium botulinum by immunofluorescence (IF). BoNT/D, or botulinum neurotoxin type D, is a potent neurotoxin produced by the anaerobic bacterium Clostridium botulinum and plays a critical role in botulism pathogenesis, a severe paralytic illness. BoNT/D consists of a heavy chain and a light chain linked by a disulfide bond, essential for function. The heavy chain facilitates toxin binding to neuronal cells, while the light chain possesses enzymatic activity that cleaves specific proteins involved in neurotransmitter release. This structural arrangement enables BoNT/D to inhibit acetylcholine release at the neuromuscular junction, leading to flaccid paralysis. Understanding BoNT/D structure remains crucial for developing therapeutic strategies and interventions for botulism, as well as creating effective vaccines. Anti-BoNT/D antibody (KB23) serves as an invaluable tool for researchers studying botulinum neurotoxin mechanisms and nervous system effects.