Salmonella core antigen Antibody (5D12A): sc-52219

Salmonella core antigen Antibody (5D12A) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Salmonella core antigen protein of Salmonella enteriditis D, paratyphi A, typhimurium B, choleraesuis, newport, anatum, and Selandia origin by immunofluorescence (IF). Anti-Salmonella core antigen antibody (5D12A) is available as a non-conjugated format. Salmonella core antigen (5D12A) antibody recognizes a crucial component in the pathogenesis of Salmonella infections, involved in the bacterium′s ability to evade host immune response. Salmonella core antigen (5D12A) monoclonal antibody targets a component of the lipopolysaccharide layer of the bacterial cell wall, which provides structural integrity and serves as a key virulence factor. Anti-Salmonella core antigen antibody (5D12A) helps identify how core antigen masks other surface antigens, enabling Salmonella to avoid detection by the host′s immune system, leading to persistent infection and increased pathogenicity. Understanding Salmonella core antigen function through Salmonella core antigen (5D12A) monoclonal antibody studies is vital for developing effective vaccines and therapeutic strategies against salmonellosis, which can cause severe gastrointestinal disease and systemic infections.

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Salmonella core antigen Antibody (5D12A) References:

1. Synthesis of the Salmonella type E(1) core trisaccharide as a probe for the generality of 1-(benzenesulfinyl)piperidine/triflic anhydride combination for glycosidic bond formation from thioglycosides.  |  Crich, D. and Li, H. 2002. J Org Chem. 67: 4640-6. PMID: 12098270
2. Homologs of the Rml enzymes from Salmonella enterica are responsible for dTDP-beta-L-rhamnose biosynthesis in the gram-positive thermophile Aneurinibacillus thermoaerophilus DSM 10155.  |  Graninger, M., et al. 2002. Appl Environ Microbiol. 68: 3708-15. PMID: 12147463
3. Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis.  |  Allende, D. and McIntosh, TJ. 2003. Biochemistry. 42: 1101-8. PMID: 12549932
4. Oral attenuated Salmonella typhimurium vaccine against MG7-Ag mimotope of gastric cancer.  |  Meng, FP., et al. 2005. World J Gastroenterol. 11: 1833-6. PMID: 15793876
5. Functional characterization of WaaL, a ligase associated with linking O-antigen polysaccharide to the core of Pseudomonas aeruginosa lipopolysaccharide.  |  Abeyrathne, PD., et al. 2005. J Bacteriol. 187: 3002-12. PMID: 15838026
6. The role of galacturonic acid in outer membrane stability in Klebsiella pneumoniae.  |  Frirdich, E., et al. 2005. J Biol Chem. 280: 27604-12. PMID: 15929980
7. Drug-lipid A interactions on the Escherichia coli ABC transporter MsbA.  |  Woebking, B., et al. 2005. J Bacteriol. 187: 6363-9. PMID: 16159769
8. Extra-intestinal manifestations of salmonella infections.  |  Cohen, JI., et al. 1987. Medicine (Baltimore). 66: 349-88. PMID: 3306260
9. Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection.  |  Otten, EG., et al. 2021. Nature. 594: 111-116. PMID: 34012115
10. Short-term dietary changes can result in mucosal and systemic immune depression.  |  Siracusa, F., et al. 2023. Nat Immunol. 24: 1473-1486. PMID: 37580603
11. Hybrid hepatitis B virus core antigen as a vaccine carrier moiety. II. Expression in avirulent Salmonella spp. for mucosal immunization.  |  Schödel, F., et al. 1996. Adv Exp Med Biol. 397: 15-21. PMID: 8718577
12. Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium.  |  Jin, UH., et al. 2001. Glycoconj J. 18: 779-87. PMID: 12441667

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Salmonella core antigen Antibody (5D12A) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Salmonella core antigen Antibody (5D12A) Specifications

Alternate Product Name: Salmonella core antigen

Product Clone Name: 5D12A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: mouse IgG₁ κ kappa light chain

Amino Acids:

Epitope Target: Salmonella core antigen

Epitope Species: Salmonella enteriditis, Salmonella paratyphi and Salmonella typhimurium

Product Reactivity/Detection: Salmonella pan group core antigen

Species Reactivity/Detection: Salmonella enteriditis D, paratyphi A, typhimurium B, cholerase, newport, anatum, Selandia

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Salmonella core antigen Antibody (5D12A): N/A