Gram Negative Endotoxin Marker Antibody (8.F.121): sc-57751

Gram Negative Endotoxin Marker Antibody (8.F.121) is a mouse monoclonal IgM antibody that detects the Gram Negative Endotoxin Marker protein of Escherichia coli J5 and Gram negative organisms by enzyme-linked immunosorbent assay (ELISA). Anti-Gram Negative Endotoxin Marker antibody (8.F.121) is available as a non-conjugated format. The Gram Negative Endotoxin Marker protein, primarily composed of lipopolysaccharide (LPS), plays a crucial role in the structural integrity and pathogenicity of Gram-negative bacteria. LPS is a major component of the outer membrane of these bacteria, and its presence is essential for maintaining the barrier function of the cell wall, which protects the bacteria from environmental stresses and antimicrobial agents. LPS is recognized by the immune system as a potent immunogen, triggering strong inflammatory responses that can lead to septic shock in severe infections. Understanding the function of the Gram Negative Endotoxin Marker protein is vital for developing therapeutic strategies against infections caused by Gram-negative bacteria, which are often resistant to multiple antibiotics.

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Gram Negative Endotoxin Marker Antibody (8.F.121) References:

1. Recognition of gram-negative bacteria and endotoxin by the innate immune system.  |  Ulevitch, RJ. and Tobias, PS. 1999. Curr Opin Immunol. 11: 19-22. PMID: 10047547
2. Macrophage migration inhibitory factor (MIF) modulates innate immune responses induced by endotoxin and Gram-negative bacteria.  |  Roger, T., et al. 2001. J Endotoxin Res. 7: 456-60. PMID: 11753217
3. [An experimental study on the release of endotoxin from gram negative bacteria induced by antibiotics].  |  Xu, N., et al. 2001. Zhonghua Shao Shang Za Zhi. 17: 75-9. PMID: 11876914
4. [Detection of the endotoxin of Gram-negative bacteria in human blood].  |  Bondarenko, VM., et al. 2002. Zh Mikrobiol Epidemiol Immunobiol. 83-9. PMID: 12043164
5. Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters.  |  Ueyama, J., et al. 2005. Eur J Pharmacol. 510: 127-34. PMID: 15740733
6. Endotoxin level as a potential marker of concentration of Gram-negative bacteria in water effluent from dental units and in dental aerosols.  |  Szymańska, J. 2005. Ann Agric Environ Med. 12: 229-32. PMID: 16457478
7. Comparative study of surgical instruments from sterile-service departments for presence of residual gram-negative endotoxin and proteinaceous deposits.  |  Lipscomb, IP., et al. 2006. J Clin Microbiol. 44: 3728-33. PMID: 16928962
8. Bactericidal permeability-increasing protein in host defence against gram-negative bacteria and endotoxin.  |  Elsbach, P. 1994. Ciba Found Symp. 186: 176-87; discussion 187-9. PMID: 7768151
9. Administration to mouse of endotoxin from gram-negative bacteria leads to activation and apoptosis of T lymphocytes.  |  Castro, A., et al. 1998. Eur J Immunol. 28: 488-95. PMID: 9521057

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Gram Negative Endotoxin Marker Antibody (8.F.121) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Gram Negative Endotoxin Marker Antibody (8.F.121) Specifications

Alternate Product Name: Gram Negative Endotoxin Marker

Product Clone Name: 8.F.121

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Gram Negative Endotoxin Marker

Epitope Species: E. coli

Product Reactivity/Detection: Gram Negative Endotoxin

Species Reactivity/Detection: Escherichia coli J5, Gram negative organisms

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Gram Negative Endotoxin Marker Antibody (8.F.121): N/A