Helicobacter pylori OMP Antibody (6631): sc-69935

Helicobacter pylori OMP Antibody (6631) is a mouse monoclonal IgG1 antibody that detects Helicobacter pylori in Helicobacter pylori samples by western blotting (WB) and immunofluorescence (IF) applications. Helicobacter pylori is a spiral-shaped Gram-negative bacterium that uniquely thrives in the highly acidic environment of the stomach, where H. pylori can cause significant gastrointestinal issues such as peptic ulcers, gastritis, and duodenitis. H. pylori is estimated to infect about 66% of the global population, although many individuals remain asymptomatic. H. pylori can be found in various niches within the gastric environment, including the mucus layer, attached to epithelial cells, or within vacuoles of epithelial cells. This strategic positioning allows H. pylori to effectively produce adhesins that bind to membrane-associated lipids and carbohydrates, facilitating adhesion to host cells. Additionally, H. pylori possesses a hydrogenase enzyme that enables energy derivation by oxidizing molecular hydrogen produced by other intestinal bacteria, while urease activity converts urea into ammonia and bicarbonate, helping to neutralize stomach acidity. The outer membrane proteins (OMPs) of H. pylori play a vital role in adhesion and can trigger signal transduction events in host cells, making OMPs essential for understanding H. pylori′s pathogenic mechanisms.

The preferred Helicobacter pylori OMP antibody is Helicobacter pylori OMP Antibody (BDI176): sc-57779.