Helicobacter pylori OMP Antibody (6631): sc-69935

Helicobacter pylori OMP Antibody (6631) is a mouse monoclonal IgG1 antibody that detects Helicobacter pylori in Helicobacter pylori samples by western blotting (WB) and immunofluorescence (IF) applications. Helicobacter pylori is a spiral-shaped Gram-negative bacterium that uniquely thrives in the highly acidic environment of the stomach, where H. pylori can cause significant gastrointestinal issues such as peptic ulcers, gastritis, and duodenitis. H. pylori is estimated to infect about 66% of the global population, although many individuals remain asymptomatic. H. pylori can be found in various niches within the gastric environment, including the mucus layer, attached to epithelial cells, or within vacuoles of epithelial cells. This strategic positioning allows H. pylori to effectively produce adhesins that bind to membrane-associated lipids and carbohydrates, facilitating adhesion to host cells. Additionally, H. pylori possesses a hydrogenase enzyme that enables energy derivation by oxidizing molecular hydrogen produced by other intestinal bacteria, while urease activity converts urea into ammonia and bicarbonate, helping to neutralize stomach acidity. The outer membrane proteins (OMPs) of H. pylori play a vital role in adhesion and can trigger signal transduction events in host cells, making OMPs essential for understanding H. pylori′s pathogenic mechanisms.

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Helicobacter pylori OMP Antibody (6631) References:

1. OMP gene deletion causes an elevation in behavioral threshold sensitivity.  |  Youngentob, SL. and Margolis, FL. 1999. Neuroreport. 10: 15-9. PMID: 10094125
2. OMP gene deletion results in an alteration in odorant quality perception.  |  Youngentob, SL., et al. 2001. Behav Neurosci. 115: 626-31. PMID: 11439451
3. The interaction of Bex and OMP reveals a dimer of OMP with a short half-life.  |  Koo, JH., et al. 2004. J Neurochem. 90: 102-16. PMID: 15198671
4. Isolation and characterization of the Omp-PA porin from Porphyromonas asaccharolytica, determination of the omp-PA gene sequence and prediction of Omp-PA protein structure.  |  Magalashvili, L., et al. 2007. Anaerobe. 13: 74-82. PMID: 17229581
5. Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.  |  Albeanu, DF., et al. 2018. Nat Commun. 9: 5073. PMID: 30498219
6. Micro-Doppler Signature Detection and Recognition of UAVs Based on OMP Algorithm.  |  Fan, S., et al. 2023. Sensors (Basel). 23: PMID: 37765981
7. Mapping of conserved immunodominant epitope peptides in the outer membrane porin (Omp) L of prominent Enterobacteriaceae pathogens associated with gastrointestinal infections.  |  Kolla, HB., et al. 2023. J Genet Eng Biotechnol. 21: 146. PMID: 38012455
8. Mindfulness-Based Cognitive Therapy-Taking it Further (MBCT-TiF) compared to Ongoing Mindfulness Practice (OMP) in the promotion of well-being and mental health: A randomised controlled trial with graduates of MBCT and MBSR.  |  Maloney, S., et al. 2024. Behav Res Ther. 173: 104478. PMID: 38244384
9. Global research Activity on olfactory marker protein (OMP): A bibliometric and visualized analysis.  |  Ab Aziz, S., et al. 2024. Heliyon. 10: e26106. PMID: 38390049
10. Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy.  |  Yan, C., et al. 2024. Acta Pharm Sin B. 14: 2281-2297. PMID: 38799628

The preferred Helicobacter pylori OMP antibody is Helicobacter pylori OMP Antibody (BDI176): sc-57779.