LTH-A Antibody (AE7): sc-52062

LTH-A Antibody (AE7) is a mouse monoclonal IgG2b antibody that detects the LTH-A protein of E. coli origin by western blotting (WB). Anti-LTH-A antibody (AE7) is available as a non-conjugated format. LTH-A protein, a heat-labile enterotoxin produced by certain strains of Enterotoxigenic E. coli (ETEC), plays a critical role in gastrointestinal pathogenesis by altering the permeability of the intestinal wall, leading to the leakage of water and electrolytes into the intestinal tract, which results in diarrhea. This enterotoxin is structurally similar to the Vibrio cholerae enterotoxin and is particularly pathogenic for humans, contributing significantly to diarrheal diseases in developing countries. Notably, LTH-A has the unique ability to penetrate intact skin and activate adaptive immunity, suggesting potential utility in the transcutaneous delivery of tumor antigens for innovative cancer immunotherapy approaches. LTH-A protein consists of a 258-amino acid precursor, while LTH-B is a shorter 103-amino acid precursor, highlighting the structural diversity within this enterotoxin family.

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LTH-A Antibody (AE7) References:

1. Heat labile enterotoxin of E. coli: a potential adjuvant for transcutaneous cancer immunotherapy.  |  Pitcovski, J., et al. 2006. Vaccine. 24: 636-43. PMID: 16157421
2. Anti-diarrheal effect of Galla Chinensis on the Escherichia coli heat-labile enterotoxin and ganglioside interaction.  |  Chen, JC., et al. 2006. J Ethnopharmacol. 103: 385-91. PMID: 16213682
3. Analysis of immune response in young and aged mice vaccinated with corn-derived antigen against Escherichia coli heat-labile enterotoxin.  |  Karaman, S., et al. 2006. Mol Biotechnol. 32: 31-42. PMID: 16382180
4. Enhanced mucosal immunogenicity of prion protein following fusion with B subunit of Escherichia coli heat-labile enterotoxin.  |  Yamanaka, H., et al. 2006. Vaccine. 24: 2815-23. PMID: 16446015
5. Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli.  |  Dorsey, FC., et al. 2006. Cell Microbiol. 8: 1516-27. PMID: 16922869
6. Monoclonal antibodies to Escherichia coli heat-labile enterotoxins: neutralising activity and differentiation of human and porcine LTs and cholera toxin.  |  Svennerholm, AM., et al. 1986. Med Biol. 64: 23-30. PMID: 3724258
7. Monoclonal antibodies with an expanded repertoire of specificities and potent neutralizing activity for Escherichia coli heat-labile enterotoxin.  |  Belisle, BW., et al. 1984. Infect Immun. 46: 759-64. PMID: 6209224
8. Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans.  |  Yamamoto, T., et al. 1984. J Biol Chem. 259: 5037-44. PMID: 6325417
9. Characterization of monoclonal antibodies to heat-labile enterotoxin encoded by a plasmid from a clinical isolate of Escherichia coli.  |  Belisle, BW., et al. 1984. Infect Immun. 43: 1027-32. PMID: 6365779

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LTH-A Antibody (AE7) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LTH-A Antibody (AE7) Specifications

Alternate Product Name: LTH-A

Product Clone Name: AE7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: LTH-A

Epitope Species: E. coli

Product Reactivity/Detection: LTH-A

Species Reactivity/Detection: E. coli

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LTH-A Antibody (AE7): N/A