Verotoxin IB Antibody (357): sc-58078

Verotoxin IB Antibody (357) is a mouse monoclonal IgG1 antibody that detects Verotoxin IB protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Verotoxin IB antibody (357) is available as a non-conjugated monoclonal isotype antibody. Verotoxin IB is a critical component of Shiga-like toxins produced by Escherichia coli, which are notorious for inducing severe gastrointestinal illness. The structure of Verotoxin IB consists of a single A subunit and five B subunits, forming a holotoxin essential for function. The A subunit is responsible for toxic effects, while B subunits facilitate toxin binding to specific receptors on target cell surfaces, such as vascular endothelial cells. This binding allows toxin entry into cells and exerts effects, including ribosome inactivation and protein synthesis disruption. Understanding Verotoxin IB structure aids therapeutic intervention development and enhances diagnostic tool design, making Verotoxin IB (357) antibody instrumental in detecting this harmful protein in clinical samples. Symptoms of Verotoxin exposure manifest rapidly, underscoring timely detection and intervention importance.

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Verotoxin IB Antibody (357) References:

1. Localization of the binding site for modified Gb3 on verotoxin 1 using fluorescence analysis.  |  Picking, WD., et al. 1999. Biochemistry. 38: 7177-84. PMID: 10353828
2. Mouse toxicity and cytokine release by verotoxin 1 B subunit mutants.  |  Wolski, VM., et al. 2001. Infect Immun. 69: 579-83. PMID: 11119557
3. A mutational analysis of the globotriaosylceramide-binding sites of verotoxin VT1.  |  Soltyk, AM., et al. 2002. J Biol Chem. 277: 5351-9. PMID: 11723119
4. Interaction of the verotoxin 1B subunit with soluble aminodeoxy analogues of globotriaosyl ceramides.  |  Mylvaganam, M., et al. 2002. Biochem J. 368: 769-76. PMID: 12175338
5. Verotoxin 1 binding to intestinal crypt epithelial cells results in localization to lysosomes and abrogation of toxicity.  |  Hoey, DE., et al. 2003. Cell Microbiol. 5: 85-97. PMID: 12580945
6. Synergistic effect of verotoxin and interferon-alpha on erythropoiesis.  |  Maloney, M. and Lingwood, C. 2003. Cell Mol Biol (Noisy-le-grand). 49: 1363-9. PMID: 14984011
7. Cytopathic effect of verotoxin on endothelial cells.  |  Kavi, J., et al. 1987. Lancet. 2: 1035. PMID: 2889952
8. Verotoxin-1 promotes leukocyte adhesion to cultured endothelial cells under physiologic flow conditions.  |  Morigi, M., et al. 1995. Blood. 86: 4553-8. PMID: 8541545
9. Localization of potential binding sites for the edema disease verotoxin (VT2e) in pigs.  |  Waddell, TE., et al. 1998. Can J Vet Res. 62: 81-6. PMID: 9553705