Date published: 2026-8-9

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GPR CRISPR Plasmids

Santa Cruz Biotechnology, Inc. offers a broad range of gene editing products including CRISPR/Cas9 Knockout and CRISPR Double Nickase plasmids for gene silencing. GPR gene silencers are available as GPR CRISPR/Cas9 Knockout plasmids and GPR Double Nickase Plasmids. GPR CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation are also available. Gene silencers and activators are useful for gene studies in combination with antibodies used for protein detection.

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GPR CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

GPR40 CRISPR/Cas9 KO Plasmid (h)

sc-401434Gene Knockouth0
(0)

GPR43 CRISPR/Cas9 KO Plasmid (h)

sc-401858Gene Knockouth0
(0)

GPR84 CRISPR/Cas9 KO Plasmid (h)

sc-401953Gene Knockouth0
(0)

GPR41 CRISPR/Cas9 KO Plasmid (h)

sc-402190Gene Knockouth0
(0)

GPR30 CRISPR/Cas9 KO Plasmid (h)

sc-402502Gene Knockouth0
(0)

GPR50 CRISPR/Cas9 KO Plasmid (h)

sc-402934Gene Knockouth0
(0)

GPR4 CRISPR/Cas9 KO Plasmid (h)

sc-403659Gene Knockouth0
(0)

GPR54 CRISPR/Cas9 KO Plasmid (h)

sc-403766Gene Knockouth0
(0)

GPR110 CRISPR/Cas9 KO Plasmid (h)

sc-405326Gene Knockouth0
(0)

GPR3 CRISPR/Cas9 KO Plasmid (h)

sc-405441Gene Knockouth0
(0)

GPR172A CRISPR/Cas9 KO Plasmid (h)

sc-405622Gene Knockouth0
(0)

GPR37L1 CRISPR/Cas9 KO Plasmid (h)

sc-405779Gene Knockouth0
(0)

GPR78 CRISPR/Cas9 KO Plasmid (h)

sc-405837Gene Knockouth0
(0)

GPR105 CRISPR/Cas9 KO Plasmid (h)

sc-405954Gene Knockouth0
(0)

GPR38 CRISPR/Cas9 KO Plasmid (h)

sc-406289Gene Knockouth0
(0)

GPR56 CRISPR/Cas9 KO Plasmid (h)

sc-406370Gene Knockouth0
(0)

GPR19 CRISPR/Cas9 KO Plasmid (h)

sc-407000Gene Knockouth0
(0)

GPR126 CRISPR/Cas9 KO Plasmid (h)

sc-407085Gene Knockouth0
(0)

GPR158 CRISPR/Cas9 KO Plasmid (h)

sc-407138Gene Knockouth0
(0)

GPR175 CRISPR/Cas9 KO Plasmid (h)

sc-407257Gene Knockouth0
(0)

GPR20 CRISPR/Cas9 KO Plasmid (h)

sc-407471Gene Knockouth0
(0)

GPR18 CRISPR/Cas9 KO Plasmid (h)

sc-407609Gene Knockouth0
(0)

GPR108 CRISPR/Cas9 KO Plasmid (h)

sc-407669Gene Knockouth0
(0)

GPR26 CRISPR/Cas9 KO Plasmid (h)

sc-407710Gene Knockouth0
(0)

GPR125 CRISPR/Cas9 KO Plasmid (h)

sc-408335Gene Knockouth0
(0)

GPR116 CRISPR/Cas9 KO Plasmid (h)

sc-408424Gene Knockouth0
(0)

GPR12 CRISPR/Cas9 KO Plasmid (h)

sc-409623Gene Knockouth0
(0)

GPR6 CRISPR/Cas9 KO Plasmid (h)

sc-410801Gene Knockouth0
(0)

GPR39 CRISPR/Cas9 KO Plasmid (h)

sc-410802Gene Knockouth0
(0)

GPR171 CRISPR/Cas9 KO Plasmid (h)

sc-412047Gene Knockouth0
(0)

GPR107 CRISPR/Cas9 KO Plasmid (h)

sc-412891Gene Knockouth0
(0)

GPR157 CRISPR/Cas9 KO Plasmid (h)

sc-413328Gene Knockouth0
(0)

GPR142 CRISPR/Cas9 KO Plasmid (h)

sc-415656Gene Knockouth0
(0)

GPR35 CRISPR/Cas9 KO Plasmid (h)

sc-416792Gene Knockouth0
(0)

GPR160 CRISPR/Cas9 KO Plasmid (h)

sc-417702Gene Knockouth0
(0)

GPR68 CRISPR/Cas9 KO Plasmid (h)

sc-418070Gene Knockouth0
(0)

GPR3 CRISPR/Cas9 KO Plasmid (m)

sc-420646Gene Knockoutm0
(0)

GPR34 CRISPR/Cas9 KO Plasmid (m)

sc-423884Gene Knockoutm0
(0)

GPR35 CRISPR/Cas9 KO Plasmid (m)

sc-425672Gene Knockoutm0
(0)

GPR39 CRISPR/Cas9 KO Plasmid (m)

sc-427882Gene Knockoutm0
(0)

GPR160 CRISPR/Cas9 KO Plasmid (m)

sc-428107Gene Knockoutm0
(0)

GPR22 CRISPR/Cas9 KO Plasmid (m)

sc-428483Gene Knockoutm0
(0)

GPR178 CRISPR/Cas9 KO Plasmid (m)

sc-429504Gene Knockoutm0
(0)

GPR91 CRISPR/Cas9 KO Plasmid (m)

sc-429973Gene Knockoutm0
(0)

GPR105 CRISPR/Cas9 KO Plasmid (m)

sc-431244Gene Knockoutm0
(0)

GPR55 CRISPR/Cas9 KO Plasmid (m)

sc-432690Gene Knockoutm0
(0)

GPR43 CRISPR/Cas9 KO Plasmid (m)

sc-433243Gene Knockoutm0
(0)

GPR41 CRISPR/Cas9 KO Plasmid (m)

sc-433244Gene Knockoutm0
(0)

GPR119 CRISPR/Cas9 KO Plasmid (m)

sc-433515Gene Knockoutm0
(0)

GPR4 CRISPR/Cas9 KO Plasmid (m)

sc-435597Gene Knockoutm0
(0)

GPR92 CRISPR/Cas9 KO Plasmid (m)

sc-436329Gene Knockoutm0
(0)

GPR56 CRISPR/Cas9 KO Plasmid (r)

sc-437293Gene Knockoutr0
(0)

GPR120 CRISPR/Cas9 KO Plasmid (r)

sc-437300Gene Knockoutr0
(0)

GPR30 HDR Plasmid (h)

sc-402502-HDRHomology Directed Repairh0
(0)

GPR50 HDR Plasmid (h)

sc-402934-HDRHomology Directed Repairh0
(0)

GPR54 HDR Plasmid (h)

sc-403766-HDRHomology Directed Repairh0
(0)

GPR110 HDR Plasmid (h)

sc-405326-HDRHomology Directed Repairh0
(0)

GPR3 HDR Plasmid (h)

sc-405441-HDRHomology Directed Repairh0
(0)

GPR37L1 HDR Plasmid (h)

sc-405779-HDRHomology Directed Repairh0
(0)

GPR56 HDR Plasmid (h)

sc-406370-HDRHomology Directed Repairh0
(0)

GPR158 HDR Plasmid (h)

sc-407138-HDRHomology Directed Repairh0
(0)

GPR175 HDR Plasmid (h)

sc-407257-HDRHomology Directed Repairh0
(0)

GPR20 HDR Plasmid (h)

sc-407471-HDRHomology Directed Repairh0
(0)

GPR18 HDR Plasmid (h)

sc-407609-HDRHomology Directed Repairh0
(0)

GPR108 HDR Plasmid (h)

sc-407669-HDRHomology Directed Repairh0
(0)

GPR26 HDR Plasmid (h)

sc-407710-HDRHomology Directed Repairh0
(0)

GPR125 HDR Plasmid (h)

sc-408335-HDRHomology Directed Repairh0
(0)

GPR116 HDR Plasmid (h)

sc-408424-HDRHomology Directed Repairh0
(0)

GPR12 HDR Plasmid (h)

sc-409623-HDRHomology Directed Repairh0
(0)

GPR6 HDR Plasmid (h)

sc-410801-HDRHomology Directed Repairh0
(0)

GPR39 HDR Plasmid (h)

sc-410802-HDRHomology Directed Repairh0
(0)

GPR107 HDR Plasmid (h)

sc-412891-HDRHomology Directed Repairh0
(0)

GPR157 HDR Plasmid (h)

sc-413328-HDRHomology Directed Repairh0
(0)

GPR35 HDR Plasmid (h)

sc-416792-HDRHomology Directed Repairh0
(0)

GPR160 HDR Plasmid (h)

sc-417702-HDRHomology Directed Repairh0
(0)

GPR68 HDR Plasmid (h)

sc-418070-HDRHomology Directed Repairh0
(0)

GPR3 HDR Plasmid (m)

sc-420646-HDRHomology Directed Repairm0
(0)

GPR34 HDR Plasmid (m)

sc-423884-HDRHomology Directed Repairm0
(0)

GPR35 HDR Plasmid (m)

sc-425672-HDRHomology Directed Repairm0
(0)

GPR160 HDR Plasmid (m)

sc-428107-HDRHomology Directed Repairm0
(0)

GPR178 HDR Plasmid (m)

sc-429504-HDRHomology Directed Repairm0
(0)

GPR91 HDR Plasmid (m)

sc-429973-HDRHomology Directed Repairm0
(0)

GPR105 HDR Plasmid (m)

sc-431244-HDRHomology Directed Repairm0
(0)

GPR43 HDR Plasmid (m)

sc-433243-HDRHomology Directed Repairm0
(0)

GPR41 HDR Plasmid (m)

sc-433244-HDRHomology Directed Repairm0
(0)

GPR4 HDR Plasmid (m)

sc-435597-HDRHomology Directed Repairm0
(0)

GPR56 HDR Plasmid (r)

sc-437293-HDRHomology Directed Repairr0
(0)

GPR120 HDR Plasmid (r)

sc-437300-HDRHomology Directed Repairr0
(0)

GPR120 CRISPR/Cas9 KO Plasmid (h2)

sc-401362-KO-2Gene Knockouth0
(0)

GPR75 CRISPR/Cas9 KO Plasmid (h2)

sc-406566-KO-2Gene Knockouth0
(0)

GPR120 HDR Plasmid (h2)

sc-401362-HDR-2Homology Directed Repairh0
(0)

GPR75 HDR Plasmid (h2)

sc-406566-HDR-2Homology Directed Repairh0
(0)

GPR CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

GPR120 Double Nickase Plasmid (h)

sc-401362-NICGene Knockouth0
(0)

GPR40 Double Nickase Plasmid (h)

sc-401434-NICGene Knockouth0
(0)

GPR43 Double Nickase Plasmid (h)

sc-401858-NICGene Knockouth0
(0)

GPR84 Double Nickase Plasmid (h)

sc-401953-NICGene Knockouth0
(0)

GPR41 Double Nickase Plasmid (h)

sc-402190-NICGene Knockouth0
(0)

GPR14 Double Nickase Plasmid (h)

sc-402393-NICGene Knockouth0
(0)

GPR30 Double Nickase Plasmid (h)

sc-402502-NICGene Knockouth0
(0)

GPR50 Double Nickase Plasmid (h)

sc-402934-NICGene Knockouth0
(0)

GPR17 Double Nickase Plasmid (h)

sc-402977-NICGene Knockouth0
(0)

GPR4 Double Nickase Plasmid (h)

sc-403659-NICGene Knockouth0
(0)

GPR54 Double Nickase Plasmid (h)

sc-403766-NICGene Knockouth0
(0)

GPR32 Double Nickase Plasmid (h)

sc-405309-NICGene Knockouth0
(0)

GPR3 Double Nickase Plasmid (h)

sc-405441-NICGene Knockouth0
(0)

GPR172A Double Nickase Plasmid (h)

sc-405622-NICGene Knockouth0
(0)

GPR56 Double Nickase Plasmid (h)

sc-406370-NICGene Knockouth0
(0)

GPR19 Double Nickase Plasmid (h)

sc-407000-NICGene Knockouth0
(0)

GPR172B Double Nickase Plasmid (h)

sc-407324-NICGene Knockouth0
(0)

GPR20 Double Nickase Plasmid (h)

sc-407471-NICGene Knockouth0
(0)

GPR125 Double Nickase Plasmid (h)

sc-408335-NICGene Knockouth0
(0)

GPR39 Double Nickase Plasmid (h)

sc-410802-NICGene Knockouth0
(0)

GPR55 Double Nickase Plasmid (h)

sc-411265-NICGene Knockouth0
(0)

GPR52 Double Nickase Plasmid (h)

sc-411266-NICGene Knockouth0
(0)

GPR174 Double Nickase Plasmid (h)

sc-413678-NICGene Knockouth0
(0)

GPR35 Double Nickase Plasmid (h)

sc-416792-NICGene Knockouth0
(0)

GPR22 Double Nickase Plasmid (h)

sc-418054-NICGene Knockouth0
(0)

GPR56 Double Nickase Plasmid (m)

sc-420657-NICGene Knockoutm0
(0)

GPR87 Double Nickase Plasmid (m)

sc-429972-NICGene Knockoutm0
(0)

GPR91 Double Nickase Plasmid (m)

sc-429973-NICGene Knockoutm0
(0)

GPR105 Double Nickase Plasmid (m)

sc-431244-NICGene Knockoutm0
(0)

GPR126 Double Nickase Plasmid (m)

sc-432032-NICGene Knockoutm0
(0)

GPR55 Double Nickase Plasmid (m)

sc-432690-NICGene Knockoutm0
(0)

GPR40 Double Nickase Plasmid (m)

sc-433245-NICGene Knockoutm0
(0)

GPR158 Double Nickase Plasmid (m)

sc-433824-NICGene Knockoutm0
(0)

GPR92 Double Nickase Plasmid (m)

sc-436329-NICGene Knockoutm0
(0)

GPR56 Double Nickase Plasmid (r)

sc-437293-NICGene Knockoutr0
(0)

GPR120 Double Nickase Plasmid (r)

sc-437300-NICGene Knockoutr0
(0)

GPR120 Double Nickase Plasmid (h2)

sc-401362-NIC-2Gene Knockouth0
(0)

GPR40 Double Nickase Plasmid (h2)

sc-401434-NIC-2Gene Knockouth0
(0)

GPR43 Double Nickase Plasmid (h2)

sc-401858-NIC-2Gene Knockouth0
(0)

GPR41 Double Nickase Plasmid (h2)

sc-402190-NIC-2Gene Knockouth0
(0)

GPR14 Double Nickase Plasmid (h2)

sc-402393-NIC-2Gene Knockouth0
(0)

GPR30 Double Nickase Plasmid (h2)

sc-402502-NIC-2Gene Knockouth0
(0)

GPR50 Double Nickase Plasmid (h2)

sc-402934-NIC-2Gene Knockouth0
(0)

GPR17 Double Nickase Plasmid (h2)

sc-402977-NIC-2Gene Knockouth0
(0)

GPR4 Double Nickase Plasmid (h2)

sc-403659-NIC-2Gene Knockouth0
(0)

GPR54 Double Nickase Plasmid (h2)

sc-403766-NIC-2Gene Knockouth0
(0)

GPR3 Double Nickase Plasmid (h2)

sc-405441-NIC-2Gene Knockouth0
(0)

GPR56 Double Nickase Plasmid (h2)

sc-406370-NIC-2Gene Knockouth0
(0)

GPR19 Double Nickase Plasmid (h2)

sc-407000-NIC-2Gene Knockouth0
(0)

GPR20 Double Nickase Plasmid (h2)

sc-407471-NIC-2Gene Knockouth0
(0)

GPR125 Double Nickase Plasmid (h2)

sc-408335-NIC-2Gene Knockouth0
(0)

GPR39 Double Nickase Plasmid (h2)

sc-410802-NIC-2Gene Knockouth0
(0)

GPR55 Double Nickase Plasmid (h2)

sc-411265-NIC-2Gene Knockouth0
(0)

GPR52 Double Nickase Plasmid (h2)

sc-411266-NIC-2Gene Knockouth0
(0)

GPR174 Double Nickase Plasmid (h2)

sc-413678-NIC-2Gene Knockouth0
(0)

GPR35 Double Nickase Plasmid (h2)

sc-416792-NIC-2Gene Knockouth0
(0)

GPR56 Double Nickase Plasmid (m2)

sc-420657-NIC-2Gene Knockoutm0
(0)

GPR91 Double Nickase Plasmid (m2)

sc-429973-NIC-2Gene Knockoutm0
(0)

GPR105 Double Nickase Plasmid (m2)

sc-431244-NIC-2Gene Knockoutm0
(0)

GPR126 Double Nickase Plasmid (m2)

sc-432032-NIC-2Gene Knockoutm0
(0)

GPR55 Double Nickase Plasmid (m2)

sc-432690-NIC-2Gene Knockoutm0
(0)

GPR158 Double Nickase Plasmid (m2)

sc-433824-NIC-2Gene Knockoutm0
(0)

GPR92 Double Nickase Plasmid (m2)

sc-436329-NIC-2Gene Knockoutm0
(0)

GPR56 Double Nickase Plasmid (r2)

sc-437293-NIC-2Gene Knockoutr0
(0)

GPR120 Double Nickase Plasmid (r2)

sc-437300-NIC-2Gene Knockoutr0
(0)

GPR CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

GPR120 CRISPR Activation Plasmid (h)

sc-401362-ACTGene Activationh0
(0)

GPR40 CRISPR Activation Plasmid (h)

sc-401434-ACTGene Activationh0
(0)

GPR43 CRISPR Activation Plasmid (h)

sc-401858-ACTGene Activationh0
(0)

GPR84 CRISPR Activation Plasmid (h)

sc-401953-ACTGene Activationh0
(0)

GPR41 CRISPR Activation Plasmid (h)

sc-402190-ACTGene Activationh0
(0)

GPR14 CRISPR Activation Plasmid (h)

sc-402393-ACTGene Activationh0
(0)

GPR30 CRISPR Activation Plasmid (h)

sc-402502-ACTGene Activationh0
(0)

GPR50 CRISPR Activation Plasmid (h)

sc-402934-ACTGene Activationh0
(0)

GPR17 CRISPR Activation Plasmid (h)

sc-402977-ACTGene Activationh0
(0)

GPR119 CRISPR Activation Plasmid (h)

sc-403135-ACTGene Activationh0
(0)

GPR91 CRISPR Activation Plasmid (h)

sc-403394-ACTGene Activationh0
(0)

GPR88 CRISPR Activation Plasmid (h)

sc-403566-ACTGene Activationh0
(0)

GPR4 CRISPR Activation Plasmid (h)

sc-403659-ACTGene Activationh0
(0)

GPR54 CRISPR Activation Plasmid (h)

sc-403766-ACTGene Activationh0
(0)

GPR110 CRISPR Activation Plasmid (h)

sc-405326-ACTGene Activationh0
(0)

GPR105 CRISPR Activation Plasmid (h)

sc-405954-ACTGene Activationh0
(0)

GPR56 CRISPR Activation Plasmid (h)

sc-406370-ACTGene Activationh0
(0)

GPR19 CRISPR Activation Plasmid (h)

sc-407000-ACTGene Activationh0
(0)

GPR158 CRISPR Activation Plasmid (h)

sc-407138-ACTGene Activationh0
(0)

GPR20 CRISPR Activation Plasmid (h)

sc-407471-ACTGene Activationh0
(0)

GPR116 CRISPR Activation Plasmid (h)

sc-408424-ACTGene Activationh0
(0)

GPR39 CRISPR Activation Plasmid (h)

sc-410802-ACTGene Activationh0
(0)

GPR171 CRISPR Activation Plasmid (h)

sc-412047-ACTGene Activationh0
(0)

GPR107 CRISPR Activation Plasmid (h)

sc-412891-ACTGene Activationh0
(0)

GPR174 CRISPR Activation Plasmid (h)

sc-413678-ACTGene Activationh0
(0)

GPR35 CRISPR Activation Plasmid (h)

sc-416792-ACTGene Activationh0
(0)

GPR34 CRISPR Activation Plasmid (m)

sc-423884-ACTGene Activationm0
(0)

GPR35 CRISPR Activation Plasmid (m)

sc-425672-ACTGene Activationm0
(0)

GPR55 CRISPR Activation Plasmid (m)

sc-432690-ACTGene Activationm0
(0)

GPR4 CRISPR Activation Plasmid (m)

sc-435597-ACTGene Activationm0
(0)

GPR120 CRISPR Activation Plasmid (m)

sc-437271-ACTGene Activationm0
(0)

GPR120 CRISPR Activation Plasmid (h2)

sc-401362-ACT-2Gene Activationh0
(0)

GPR40 CRISPR Activation Plasmid (h2)

sc-401434-ACT-2Gene Activationh0
(0)

GPR43 CRISPR Activation Plasmid (h2)

sc-401858-ACT-2Gene Activationh0
(0)

GPR30 CRISPR Activation Plasmid (h2)

sc-402502-ACT-2Gene Activationh0
(0)

GPR50 CRISPR Activation Plasmid (h2)

sc-402934-ACT-2Gene Activationh0
(0)

GPR119 CRISPR Activation Plasmid (h2)

sc-403135-ACT-2Gene Activationh0
(0)

GPR54 CRISPR Activation Plasmid (h2)

sc-403766-ACT-2Gene Activationh0
(0)

GPR110 CRISPR Activation Plasmid (h2)

sc-405326-ACT-2Gene Activationh0
(0)

GPR105 CRISPR Activation Plasmid (h2)

sc-405954-ACT-2Gene Activationh0
(0)

GPR34 CRISPR Activation Plasmid (h2)

sc-405989-ACT-2Gene Activationh0
(0)

GPR56 CRISPR Activation Plasmid (h2)

sc-406370-ACT-2Gene Activationh0
(0)

GPR19 CRISPR Activation Plasmid (h2)

sc-407000-ACT-2Gene Activationh0
(0)

GPR158 CRISPR Activation Plasmid (h2)

sc-407138-ACT-2Gene Activationh0
(0)

GPR20 CRISPR Activation Plasmid (h2)

sc-407471-ACT-2Gene Activationh0
(0)

GPR174 CRISPR Activation Plasmid (h2)

sc-413678-ACT-2Gene Activationh0
(0)

GPR34 CRISPR Activation Plasmid (m2)

sc-423884-ACT-2Gene Activationm0
(0)

GPR54 Lentiviral Activation Particles (h)

sc-403766-LACGene Activationh0
(0)

GPR105 Lentiviral Activation Particles (h)

sc-405954-LACGene Activationh0
(0)

GPR56 Lentiviral Activation Particles (h)

sc-406370-LACGene Activationh0
(0)

GPR116 Lentiviral Activation Particles (h)

sc-408424-LACGene Activationh0
(0)

GPR171 Lentiviral Activation Particles (h)

sc-412047-LACGene Activationh0
(0)

GPR35 Lentiviral Activation Particles (h)

sc-416792-LACGene Activationh0
(0)

GPR35 Lentiviral Activation Particles (m)

sc-425672-LACGene Activationm0
(0)

GPR4 Lentiviral Activation Particles (m)

sc-435597-LACGene Activationm0
(0)

GPR40 Lentiviral Activation Particles (h2)

sc-401434-LAC-2Gene Activationh0
(0)

GPR43 Lentiviral Activation Particles (h2)

sc-401858-LAC-2Gene Activationh0
(0)

GPR56 Lentiviral Activation Particles (h2)

sc-406370-LAC-2Gene Activationh0
(0)