Topo Antibodies
Santa Cruz Biotechnology supplies a comprehensive collection of Topo Antibodies for studying topoisomerases, essential enzymes that regulate the overwinding or underwinding of DNA. Topo Antibodies are compatible with multiple research techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Topoisomerases play a critical role in DNA replication, transcription, and repair, making them vital for maintaining genomic stability and cellular function. Understanding topoisomerase activity has significant implications for cancer research and therapeutic development. Researchers can investigate DNA topology changes during various cellular processes using specific monoclonal antibodies. Advanced visualization techniques with fluorescent conjugates like horseradish peroxidase (HRP), phycoerythrin (PE), and fluorescein isothiocyanate (FITC) enable detailed analysis of topoisomerase localization and function. Exploring topoisomerase mechanisms helps advance our understanding of DNA maintenance and repair pathways. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific knowledge about topoisomerases and their role in human health and disease.
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Topo Antibodies
| Empty Table Header | Product Name | CATALOG # | ISOTYPE | EPITOPE | APPLICATIONS | Species | Citations | RATING |
|---|---|---|---|---|---|---|---|---|
Topo I Antibody (C-21) | sc-32736 | mouse IgM κ | FL (h) | WB, IP, IF, IHC(P) | m, r, h | 31 | ||
Topo I Antibody (H-5) | sc-271285 | mouse IgG1 κ | 685-765 (h) | WB, IP, IF, ELISA | m, r, h | 18 | ||
Topo IIα Antibody (F-12) | sc-365916 | mouse IgG1 κ | 1511-1530 (h) | WB, IP, IF, IHC(P), ELISA | m, r, h | 24 | ||
Topo IIα Antibody (G-6) | sc-166934 | mouse IgG2b κ | 1301-1531 (h) | WB, IP, IF, IHC(P), ELISA | h | 5 | ||
Topo IIα Antibody (A-8) | sc-165986 | mouse IgG1 κ | 1301-1531 (h) | WB, IP, IF, ELISA | h | 6 | ||
Topo IIα Antibody (B-6) | sc-365918 | mouse IgG2b κ | 1483-1517 (h) | WB, IP, IF, ELISA | h | 1 | ||
Topo IIα Antibody (E-10) | sc-365799 | mouse IgM κ | 1511-1530 (h) | WB, IP, IF, ELISA | m, r, h | 1 | ||
Topo IIα Antibody (E-11) | sc-365917 | mouse IgG1 κ | 1483-1517 (h) | WB, IP, IF, ELISA | h | new | ||
Topo IIα Antibody (G-9) | sc-166232 | mouse IgG1 κ | 1301-1531 (h) | WB, IP, IF, ELISA | h | new | ||
Topo IIβ Antibody (H-8) | sc-25330 | mouse IgG1 κ | 1341-1626 (h) | WB, IP, IF, IHC(P), ELISA | m, r, h | 26 | ||
Topo IIβ Antibody (A-12) | sc-365071 | mouse IgG2a κ | 1579-1611 (h) | WB, IP, IF, IHC(P), ELISA | m, r, h | 8 | ||
Topo IIβ Antibody (C-12) | sc-48429 | mouse IgG1 κ | 1341-1626 (h) | WB, IP, IF, ELISA | m, r, h | 4 | ||
Topo IIβ Antibody (B-6) | sc-365952 | mouse IgG1 κ | 1579-1611 (h) | WB, IP, IF, ELISA | m, r, h | new | ||
Topo IIβ Antibody (D-1) | sc-365421 | mouse IgG3 κ | 1579-1611 (h) | WB, IP, IF, ELISA | m, r, h | 1 | ||
Topo IIIβ-1 Antibody (B-10) | sc-137238 | mouse IgG2b κ | 563-862 (h) | WB, IP, IF, ELISA | m, r, h | 1 |
Non-Mammalian Topo Antibodies
| Empty Table Header | Product Name | CATALOG # | ISOTYPE | EPITOPE | APPLICATIONS | Species | Citations | RATING |
|---|---|---|---|---|---|---|---|---|
Topo II Antibody (T22C5) | sc-65743 | mouse IgG1 κ | (Drosophila melanogaster) | WB, IP | d | 4 | ||
Topo II Antibody (T21D4) | sc-65742 | mouse IgG2b κ | (Drosophila melanogaster) | WB | d | new |
Topo CRISPR Knockout, HDR and Double Nickase Plasmids
| Empty Table Header | Product Name | CATALOG # | Species | APPLICATIONS | MARKER | Citations | RATING |
|---|---|---|---|---|---|---|---|
Topo I CRISPR/Cas9 KO Plasmid (h) | sc-400965 | h | Gene Knockout | GFP | 0 | ||
Topo I HDR Plasmid (h) | sc-400965-HDR | h | Homology Directed Repair | Puromycin | 0 | ||
Topo I Double Nickase Plasmid (h) | sc-400965-NIC | h | Gene Knockout | Puromycin | 0 | ||
Topo I Double Nickase Plasmid (h2) | sc-400965-NIC-2 | h | Gene Knockout | Puromycin | 0 | ||
Topo I CRISPR/Cas9 KO Plasmid (m) | sc-423468 | m | Gene Knockout | GFP | 0 | ||
Topo I HDR Plasmid (m) | sc-423468-HDR | m | Homology Directed Repair | Puromycin | 0 | ||
Topo I Double Nickase Plasmid (m) | sc-423468-NIC | m | Gene Knockout | Puromycin | 0 | ||
Topo I Double Nickase Plasmid (m2) | sc-423468-NIC-2 | m | Gene Knockout | Puromycin | 0 | ||
Topo IIα CRISPR/Cas9 KO Plasmid (h) | sc-400869 | h | Gene Knockout | GFP | 1 | ||
Topo IIα HDR Plasmid (h) | sc-400869-HDR | h | Homology Directed Repair | Puromycin | 1 | ||
Topo IIα Double Nickase Plasmid (h) | sc-400869-NIC | h | Gene Knockout | Puromycin | 1 | ||
Topo IIα Double Nickase Plasmid (h2) | sc-400869-NIC-2 | h | Gene Knockout | Puromycin | 1 | ||
Topo IIα CRISPR/Cas9 KO Plasmid (m) | sc-423469 | m | Gene Knockout | GFP | 1 | ||
Topo IIα HDR Plasmid (m) | sc-423469-HDR | m | Homology Directed Repair | Puromycin | 1 | ||
Topo IIα Double Nickase Plasmid (m) | sc-423469-NIC | m | Gene Knockout | Puromycin | 1 | ||
Topo IIα Double Nickase Plasmid (m2) | sc-423469-NIC-2 | m | Gene Knockout | Puromycin | 1 | ||
Topo IIβ CRISPR/Cas9 KO Plasmid (h) | sc-400773 | h | Gene Knockout | GFP | 0 | ||
Topo IIβ HDR Plasmid (h) | sc-400773-HDR | h | Homology Directed Repair | Puromycin | 0 | ||
Topo IIβ Double Nickase Plasmid (h) | sc-400773-NIC | h | Gene Knockout | Puromycin | 0 | ||
Topo IIβ Double Nickase Plasmid (h2) | sc-400773-NIC-2 | h | Gene Knockout | Puromycin | 0 | ||
Topo IIβ CRISPR/Cas9 KO Plasmid (m) | sc-423470 | m | Gene Knockout | GFP | 1 | ||
Topo IIβ HDR Plasmid (m) | sc-423470-HDR | m | Homology Directed Repair | Puromycin | 1 | ||
Topo IIβ Double Nickase Plasmid (m) | sc-423470-NIC | m | Gene Knockout | Puromycin | 1 | ||
Topo IIβ Double Nickase Plasmid (m2) | sc-423470-NIC-2 | m | Gene Knockout | Puromycin | 1 | ||
Topo IIIα CRISPR/Cas9 KO Plasmid (h) | sc-404439 | h | Gene Knockout | GFP | 0 | ||
Topo IIIα HDR Plasmid (h) | sc-404439-HDR | h | Homology Directed Repair | Puromycin | 0 | ||
Topo IIIα Double Nickase Plasmid (h) | sc-404439-NIC | h | Gene Knockout | Puromycin | 0 | ||
Topo IIIα Double Nickase Plasmid (h2) | sc-404439-NIC-2 | h | Gene Knockout | Puromycin | 0 | ||
Topo IIIα CRISPR/Cas9 KO Plasmid (m) | sc-423471 | m | Gene Knockout | GFP | 0 | ||
Topo IIIα Double Nickase Plasmid (m) | sc-423471-NIC | m | Gene Knockout | Puromycin | 0 | ||
Topo IIIα Double Nickase Plasmid (m2) | sc-423471-NIC-2 | m | Gene Knockout | Puromycin | 0 | ||
Topo IIIβ CRISPR/Cas9 KO Plasmid (h) | sc-406840 | h | Gene Knockout | GFP | 0 | ||
Topo IIIβ Double Nickase Plasmid (h) | sc-406840-NIC | h | Gene Knockout | Puromycin | 0 | ||
Topo IIIβ Double Nickase Plasmid (h2) | sc-406840-NIC-2 | h | Gene Knockout | Puromycin | 0 | ||
Topo IIIβ CRISPR/Cas9 KO Plasmid (m) | sc-423472 | m | Gene Knockout | GFP | 0 | ||
Topo IIIβ CRISPR/Cas9 KO Plasmid (m) | sc-423472-KO-2 | m | Gene Knockout | GFP | 0 | ||
Topo IIIβ HDR Plasmid (m2) | sc-423472-HDR-2 | m | Homology Directed Repair | Puromycin | 0 | ||
Topo IIIβ Double Nickase Plasmid (m) | sc-423472-NIC | m | Gene Knockout | Puromycin | 0 | ||
Topo IIIβ Double Nickase Plasmid (m2) | sc-423472-NIC-2 | m | Gene Knockout | Puromycin | 0 |
Topo CRISPR Activation Products
| Empty Table Header | Product Name | CATALOG # | Species | APPLICATIONS | MARKER | Citations | RATING |
|---|---|---|---|---|---|---|---|
Topo I CRISPR Activation Plasmid (h) | sc-400965-ACT | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I CRISPR Activation Plasmid (h2) | sc-400965-ACT-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I Lentiviral Activation Particles (h) | sc-400965-LAC | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I Lentiviral Activation Particles (h2) | sc-400965-LAC-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I CRISPR Activation Plasmid (m) | sc-423468-ACT | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I CRISPR Activation Plasmid (m2) | sc-423468-ACT-2 | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I Lentiviral Activation Particles (m) | sc-423468-LAC | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo I Lentiviral Activation Particles (m2) | sc-423468-LAC-2 | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIα CRISPR Activation Plasmid (h) | sc-400869-ACT | h | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα CRISPR Activation Plasmid (h2) | sc-400869-ACT-2 | h | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα Lentiviral Activation Particles (h) | sc-400869-LAC | h | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα Lentiviral Activation Particles (h2) | sc-400869-LAC-2 | h | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα CRISPR Activation Plasmid (m) | sc-423469-ACT | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα CRISPR Activation Plasmid (m2) | sc-423469-ACT-2 | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα Lentiviral Activation Particles (m) | sc-423469-LAC | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIα Lentiviral Activation Particles (m2) | sc-423469-LAC-2 | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIβ CRISPR Activation Plasmid (h) | sc-400773-ACT | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIβ CRISPR Activation Plasmid (h2) | sc-400773-ACT-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIβ Lentiviral Activation Particles (h) | sc-400773-LAC | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIβ Lentiviral Activation Particles (h2) | sc-400773-LAC-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIβ CRISPR Activation Plasmid (m) | sc-423470-ACT | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIβ CRISPR Activation Plasmid (m2) | sc-423470-ACT-2 | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIβ Lentiviral Activation Particles (m) | sc-423470-LAC | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIβ Lentiviral Activation Particles (m2) | sc-423470-LAC-2 | m | Gene Activation | Puro, Blast, Hygro | 1 | ||
Topo IIIα CRISPR Activation Plasmid (h) | sc-404439-ACT | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα CRISPR Activation Plasmid (h2) | sc-404439-ACT-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα Lentiviral Activation Particles (h) | sc-404439-LAC | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα Lentiviral Activation Particles (h2) | sc-404439-LAC-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα CRISPR Activation Plasmid (m) | sc-423471-ACT | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα CRISPR Activation Plasmid (m2) | sc-423471-ACT-2 | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα Lentiviral Activation Particles (m) | sc-423471-LAC | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIα Lentiviral Activation Particles (m2) | sc-423471-LAC-2 | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ CRISPR Activation Plasmid (h) | sc-406840-ACT | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ CRISPR Activation Plasmid (h2) | sc-406840-ACT-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ Lentiviral Activation Particles (h) | sc-406840-LAC | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ Lentiviral Activation Particles (h2) | sc-406840-LAC-2 | h | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ CRISPR Activation Plasmid (m) | sc-423472-ACT | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ CRISPR Activation Plasmid (m2) | sc-423472-ACT-2 | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ Lentiviral Activation Particles (m) | sc-423472-LAC | m | Gene Activation | Puro, Blast, Hygro | 0 | ||
Topo IIIβ Lentiviral Activation Particles (m2) | sc-423472-LAC-2 | m | Gene Activation | Puro, Blast, Hygro | 0 |
Topo siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers
| Empty Table Header | Product Name | CATALOG # | Species | APPLICATIONS | MARKER | Citations | RATING |
|---|---|---|---|---|---|---|---|
Topo I siRNA (h) | sc-36694 | h | Gene Silencing | N/A | 5 | ||
Topo I shRNA Plasmid (h) | sc-36694-SH | h | Gene Silencing | Puromycin | 5 | ||
Topo I shRNA (h) Lentiviral Particles | sc-36694-V | h | Gene Silencing | Puromycin | 5 | ||
Topo I siRNA (m) | sc-36693 | m | Gene Silencing | N/A | 1 | ||
Topo I shRNA Plasmid (m) | sc-36693-SH | m | Gene Silencing | Puromycin | 1 | ||
Topo I shRNA (m) Lentiviral Particles | sc-36693-V | m | Gene Silencing | Puromycin | 1 | ||
Topo IIα siRNA (h) | sc-36695 | h | Gene Silencing | N/A | 10 | ||
Topo IIα shRNA Plasmid (h) | sc-36695-SH | h | Gene Silencing | Puromycin | 10 | ||
Topo IIα shRNA (h) Lentiviral Particles | sc-36695-V | h | Gene Silencing | Puromycin | 10 | ||
Topo IIα siRNA (m) | sc-36696 | m | Gene Silencing | N/A | 0 | ||
Topo IIα shRNA Plasmid (m) | sc-36696-SH | m | Gene Silencing | Puromycin | 0 | ||
Topo IIα shRNA (m) Lentiviral Particles | sc-36696-V | m | Gene Silencing | Puromycin | 0 | ||
Topo IIβ siRNA (h) | sc-36697 | h | Gene Silencing | N/A | 0 | ||
Topo IIβ siRNA (h2) | sc-44161 | h | Gene Silencing | N/A | 0 | ||
Topo IIβ shRNA Plasmid (h) | sc-36697-SH | h | Gene Silencing | Puromycin | 0 | ||
Topo IIβ shRNA Plasmid (h2) | sc-44161-SH | h | Gene Silencing | Puromycin | 0 | ||
Topo IIβ shRNA (h) Lentiviral Particles | sc-36697-V | h | Gene Silencing | Puromycin | 0 | ||
Topo IIβ shRNA (h2) Lentiviral Particles | sc-44161-V | h | Gene Silencing | Puromycin | 0 | ||
Topo IIβ siRNA (m) | sc-36698 | m | Gene Silencing | N/A | 0 | ||
Topo IIβ shRNA Plasmid (m) | sc-36698-SH | m | Gene Silencing | Puromycin | 0 | ||
Topo IIβ shRNA (m) Lentiviral Particles | sc-36698-V | m | Gene Silencing | Puromycin | 0 | ||
Topo IIIα siRNA (h) | sc-36699 | h | Gene Silencing | N/A | 0 | ||
Topo IIIα shRNA Plasmid (h) | sc-36699-SH | h | Gene Silencing | Puromycin | 0 | ||
Topo IIIα shRNA (h) Lentiviral Particles | sc-36699-V | h | Gene Silencing | Puromycin | 0 | ||
Topo IIIα siRNA (m) | sc-36700 | m | Gene Silencing | N/A | 0 | ||
Topo IIIα shRNA Plasmid (m) | sc-36700-SH | m | Gene Silencing | Puromycin | 0 | ||
Topo IIIα shRNA (m) Lentiviral Particles | sc-36700-V | m | Gene Silencing | Puromycin | 0 | ||
Topo IIIβ siRNA (h) | sc-36701 | h | Gene Silencing | N/A | 0 | ||
Topo IIIβ shRNA Plasmid (h) | sc-36701-SH | h | Gene Silencing | Puromycin | 0 | ||
Topo IIIβ shRNA (h) Lentiviral Particles | sc-36701-V | h | Gene Silencing | Puromycin | 0 | ||
Topo IIIβ siRNA (m) | sc-36702 | m | Gene Silencing | N/A | 0 | ||
Topo IIIβ shRNA Plasmid (m) | sc-36702-SH | m | Gene Silencing | Puromycin | 0 | ||
Topo IIIβ shRNA (m) Lentiviral Particles | sc-36702-V | m | Gene Silencing | Puromycin | 0 |