Topo IIα Antibody (E-11): sc-365917

Topo IIα Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Topoisomerase II alpha (Topo IIα), also known as DNA Topoisomerase II alpha or TOP2A. Anti-Topo IIα antibody (E-11) targets an epitope located between amino acids 1483-1517 near the C-terminus of the human Topo IIα protein, ensuring precise and reliable binding. Topo IIα is a crucial nuclear enzyme that plays a vital role in regulating DNA topology during essential cellular processes such as DNA replication, transcription, and chromosome segregation. By inducing transient double-strand breaks, Topo IIα facilitates the untangling and proper segregation of chromosomes, thereby maintaining genomic stability. This function is particularly important in rapidly dividing cells, making Topo IIα a key target for numerous anticancer drugs and therapies. Anti-Topo IIα antibody (E-11) is optimized for use in various immunoassays including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), providing versatility for diverse research applications. Additionally, Topo IIα interacts with several critical proteins such as BRCA1 and p53, which are integral to DNA damage response and tumor suppression, highlighting the importance of Topo IIα monoclonal antibody (E-11) in cancer research and molecular biology. Whether investigating the mechanisms of DNA topology regulation or developing novel therapeutic agents, anti-Topo IIα antibody (E-11) serves as an indispensable tool for scientists aiming to elucidate the complex roles of Topo IIα in cellular function and disease.

The preferred Topo IIα antibody is Topo IIα Antibody (F-12): sc-365916.