Topo IIα Antibody (B-6): sc-365918

Topo IIα Antibody (B-6) is a mouse monoclonal IgG2b kappa light chain antibody engineered to detect Topoisomerase II alpha (Topo IIα), also known as DNA Topoisomerase II alpha or TOP2A. Anti-Topo IIα antibody (B-6) specifically binds to an epitope located between amino acids 1483-1517 near the C-terminus of the human Topo IIα protein, ensuring precise and reliable detection. Topo IIα is a vital nuclear enzyme that plays a critical role in maintaining DNA topology by facilitating processes such as DNA replication, transcription, and chromosome segregation within the cell nucleus. Topo IIα′s presence in the nucleus is essential for the proper management of DNA supercoiling and untangling during cell division, which is crucial for maintaining genomic stability and preventing mutations. Topo IIα interacts with various cellular proteins involved in DNA repair and cell cycle regulation, highlighting its importance in cellular health and its potential as a target for anticancer therapies. Topo IIα monoclonal antibody (B-6) is optimized for use in multiple immunoassays, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), providing versatility for diverse research applications focused on human samples. The high specificity for human Topo IIα minimizes cross-reactivity, ensuring accurate and consistent results in studies investigating cellular mechanisms and disease states. Anti-Topo IIα antibody (B-6) is an indispensable tool for researchers exploring the intricate dynamics of DNA topology and its implications in cancer and other proliferative diseases.

The preferred Topo IIα antibody is Topo IIα Antibody (F-12): sc-365916.