Topo IIβ Antibody (C-12): sc-48429
- Topo IIβ Antibody (C-12) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1341-1626 of Topo IIb of human origin
- recommended for detection of Topo IIβ of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Topo IIβ Antibody (C-12) for WB applications. These reagents are now offered in bundles with Topo IIβ Antibody (C-12) (see ordering information below).
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Topo IIβ Antibody (C-12) is a mouse monoclonal IgG1 antibody that detects Topo IIβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Topo IIβ is a crucial nuclear enzyme that plays a significant role in DNA topology regulation, particularly during DNA replication and transcription. Unlike Topo IIα, which shows broader expression, Topo IIβ exhibits a unique expression pattern particularly important in neuronal development and function. The distinct C-terminal region of Topo IIβ suggests specialized roles in certain tissues, potentially influencing cellular responses to DNA damage and gene expression regulation. This specificity makes anti-Topo IIβ antibody (C-12) a vital tool for understanding mechanisms of cellular differentiation and cancer development, as Topo IIβ dysregulation can lead to genomic instability. Topo IIβ (C-12) antibody serves as an essential tool for researchers investigating these critical biological processes and therapeutic implications in cancer treatment.
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Topo IIβ Antibody (C-12) References:
- Altered drug interaction and regulation of topoisomerase IIbeta: potential mechanisms governing sensitivity of HL-60 cells to amsacrine and etoposide. | Grabowski, DR., et al. 1999. Mol Pharmacol. 56: 1340-5. PMID: 10570063
- The function of DNA topoisomerase IIβ in neuronal development. | Heng, X. and Le, WD. 2010. Neurosci Bull. 26: 411-6. PMID: 20882068
- HIV-1 associated Topoisomerase IIβ kinase: a potential pharmacological target for viral replication. | Ponraj, K., et al. 2013. Curr Pharm Des. 19: 4776-86. PMID: 23260019
- DNA topoisomerase IIβ as a molecular switch in neural differentiation of mesenchymal stem cells. | Isik, S., et al. 2015. Ann Hematol. 94: 307-18. PMID: 25217229
- Topoisomerase IIβ and its role in different biological contexts. | Bollimpelli, VS., et al. 2017. Arch Biochem Biophys. 633: 78-84. PMID: 28669856
- Dynamic behavior of DNA topoisomerase IIβ in response to DNA double-strand breaks. | Morotomi-Yano, K., et al. 2018. Sci Rep. 8: 10344. PMID: 29985428
- BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ. | Bunch, H., et al. 2021. Open Biol. 11: 210221. PMID: 34610268
- Disease-associated mutations in topoisomerase IIβ result in defective NK cells. | Broderick, L., et al. 2022. J Allergy Clin Immunol. 149: 2171-2176.e3. PMID: 35063500
- Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription. | Oelschläger, L., et al. 2023. Cells. 12: PMID: 36766705
- Use of CRISPR/Cas9 with Homology-Directed Repair to Gene-Edit Topoisomerase IIβ in Human Leukemia K562 Cells: Generation of a Resistance Phenotype. | Carvajal-Moreno, J., et al. 2024. J Pharmacol Exp Ther. 389: 186-196. PMID: 38508753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Topo IIβ Antibody (C-12) | sc-48429 | 200 µg/ml | $316.00 | |||
Topo IIβ Antibody (C-12): m-IgG Fc BP-HRP Bundle | sc-536843 | 200 µg Ab; 10 µg BP | $354.00 | |||
Topo IIβ Antibody (C-12): m-IgGκ BP-HRP Bundle | sc-534010 | 200 µg Ab; 40 µg BP | $354.00 | |||
Topo IIβ Antibody (C-12): m-IgG1 BP-HRP Bundle | sc-544853 | 200 µg Ab; 20 µg BP | $354.00 |