Date published: 2026-1-9

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Topo II beta Inhibitors

Santa Cruz Biotechnology now offers a broad range of Topo II beta Inhibitors for use in various applications. Topo II beta inhibitors are specialized chemicals that interfere with the activity of the enzyme topoisomerase II beta, a key player in DNA replication and transcription processes. Inhibiting this enzyme's function can lead to alterations in DNA topology, making these inhibitors invaluable tools in genetic and molecular biology research. They are commonly utilized in studies aimed at understanding DNA repair mechanisms, chromosomal segregation, and the regulation of gene expression. Additionally, Topo II beta inhibitors have been pivotal in the development of methods for studying the effects of DNA damage and the cellular response to stress, contributing to our broader understanding of genomic stability. These inhibitors are also used in the research of cell cycle dynamics, where they help explain the complex interactions that control cell division and proliferation. By providing precise control over topoisomerase II beta activity, researchers can dissect the roles of various cellular processes and gain insights into fundamental biological mechanisms. View detailed information on our available Topo II beta Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

ICRF-193

21416-68-2sc-200889
sc-200889A
1 mg
5 mg
$341.00
$927.00
7
(1)

ICRF-193 acts as a selective inhibitor of topoisomerase II beta, exhibiting a unique binding affinity that disrupts the enzyme's catalytic cycle. This compound stabilizes the enzyme-DNA complex, preventing the necessary conformational changes for effective DNA strand passage. Its specific interactions with the enzyme's active site alter reaction kinetics, leading to an accumulation of DNA entanglements. The compound's structural features contribute to its ability to modulate the enzyme's function, impacting cellular processes related to DNA topology.

BNS-22

1151668-24-4sc-364676
10 mg
$193.00
(0)

BNS-22 functions as a potent inhibitor of topoisomerase II beta, characterized by its ability to form stable complexes with the enzyme. This compound uniquely alters the enzyme's conformational dynamics, hindering its ability to facilitate DNA strand passage. BNS-22's distinct molecular interactions enhance the stabilization of the enzyme-DNA complex, resulting in a significant alteration of reaction kinetics and an increase in DNA supercoiling. Its specific structural attributes play a crucial role in modulating topological changes within cellular DNA.