| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $341.00 $927.00 | 7 | |
ICRF-193 acts as a selective inhibitor of topoisomerase II beta, exhibiting a unique binding affinity that disrupts the enzyme's catalytic cycle. This compound stabilizes the enzyme-DNA complex, preventing the necessary conformational changes for effective DNA strand passage. Its specific interactions with the enzyme's active site alter reaction kinetics, leading to an accumulation of DNA entanglements. The compound's structural features contribute to its ability to modulate the enzyme's function, impacting cellular processes related to DNA topology. | ||||||
BNS-22 | 1151668-24-4 | sc-364676 | 10 mg | $193.00 | ||
BNS-22 functions as a potent inhibitor of topoisomerase II beta, characterized by its ability to form stable complexes with the enzyme. This compound uniquely alters the enzyme's conformational dynamics, hindering its ability to facilitate DNA strand passage. BNS-22's distinct molecular interactions enhance the stabilization of the enzyme-DNA complex, resulting in a significant alteration of reaction kinetics and an increase in DNA supercoiling. Its specific structural attributes play a crucial role in modulating topological changes within cellular DNA. | ||||||