Date published: 2026-3-31

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PLC Antibodies

Santa Cruz Biotechnology features a diverse variety of PLC monoclonal antibodies for studying phospholipase C (PLC) proteins in research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Phospholipase C plays a key role in cellular signaling pathways by hydrolyzing phosphatidylinositol 4,5-bisphosphate to generate inositol trisphosphate and diacylglycerol, which are essential for the regulation of intracellular calcium levels and activation of protein kinase C. Understanding PLC function is crucial for research in cell growth, differentiation, and apoptosis. PLC monoclonal antibodies enable precise detection and analysis of phospholipase C expression and activity. Researchers can investigate PLC's role in various cellular processes and signaling cascades. Studying phospholipase C contributes to understanding both normal cellular functions and disease mechanisms. Santa Cruz Biotechnology monoclonal antibodies for PLC support researchers worldwide in advancing scientific knowledge of cellular signaling pathways.

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PLC Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

PLC β1 Antibody (D-8)

sc-5291mouse IgG2b κ831-1063 (r)WB, IP, IF, IHC(P), ELISAm, r, h
46
(10)

PLC β2 Antibody (B-2)

sc-515912mouse IgG2b κ794-818 (h)WB, IP, IF, ELISAm, r, h
6
(2)

PLC β3 Antibody (D-7)

sc-133231mouse IgG2a κ1151-1234 (h)WB, IP, IF, IHC(P), ELISAm, r, h
12
(6)

PLC β3 Antibody (H-1)

sc-271372mouse IgG2a κ11-42 (h)WB, IP, IF, ELISAm, r, h

new

(1)

PLC β3 Antibody (H-3)

sc-133140mouse IgG2a κ1151-1234 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(2)

PLC β4 Antibody (A-8)

sc-166131mouse IgG2a κ876-1115 (h)WB, IP, IF, IHC(P), ELISAm, r, h
10
(7)

PLC β4 Antibody (56)

sc-136041mouse IgG1752-961 (h)WB, IP, IFm, r, h

new

(1)

PLC β4 Antibody (D-7)

sc-166133mouse IgG1 κ876-1115 (h)WB, IP, IF, ELISAm, r, h

new

(3)

PLC β4 Antibody (E-1)

sc-166132mouse IgG2a κ876-1115 (h)WB, IP, IF, ELISAm, r, h

new

(3)

PLC δ1 Antibody (D-7)

sc-393464mouse IgG1 κ71-92 (h)WB, IP, IF, ELISAm, r, h
4
(2)

PLC δ1 Antibody (A-2)

sc-365811mouse IgG1 κ1-140 (h)WB, IP, IF, ELISAm, r, h
1
(1)

PLC δ1 Antibody (A-4)

sc-365812mouse IgG1 κ1-140 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(3)

PLC δ1 Antibody (B-9)

sc-376058mouse IgG2b κ2-31 (h)WB, IP, IF, IHC(P), ELISAm, r, h

new

(2)

PLC δ1 Antibody (D-10)

sc-374329mouse IgG1 κ2-31 (h)WB, IP, IF, ELISAm, r, h
2
(2)

PLC δ3 Antibody (E-5)

sc-514912mouse IgG1 κ517-535 (h)WB, IP, IF, ELISAm, r, h
3
(2)

PLC δ4 Antibody (B-2)

sc-373875mouse IgG1 κ1-250 (h)WB, IP, IF, IHC(P), ELISAm, r, h
3
(3)

PLC γ1 Antibody (E-12)

sc-7290mouse IgG3 κC-terminal (bovine)WB, IP, IF, IHC(P), ELISAm, r, h
106
(16)

PLC γ1 Antibody (1F1)

sc-58407mouse IgG2aFL (h)WB, IP, ELISAm, r, h
4
(3)

PLC γ1 Antibody (H-3)

sc-166938mouse IgG1 κ530-850 (r)WB, IP, IF, IHC(P), ELISAm, r, h
4
(3)

PLC γ1 Antibody (B-4)

sc-374467mouse IgG1 κ75-115 (h)WB, IP, IF, ELISAm, r, h
3
(2)

PLC γ2 Antibody (B-10)

sc-5283mouse IgG1 κ826-985 (h)WB, IP, IF, IHC(P), ELISAm, r, h
47
(10)

PLC γ2 Antibody (A-3)

sc-390389mouse IgG2b κ935-971 (h)WB, IP, IF, ELISAm, r, h

new

(1)

PLC-XD1 Antibody (A-1)

sc-393244mouse IgG1 κ42-59 (h)WB, IP, IF, ELISAm, r, h

new

(2)

Phospho-Specific PLC Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p-PLC γ1 Antibody (pY783.27)

sc-136186mouse IgG1 κTyr 783 (h)WB, IPm, r, h
5
(6)

PLC CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

PLC-L CRISPR/Cas9 KO Plasmid (m)

sc-432677mGene KnockoutGFP0
(0)

PLC-L HDR Plasmid (m)

sc-432677-HDRmHomology Directed RepairPuromycin0
(0)

PLC β1 CRISPR/Cas9 KO Plasmid (h)

sc-401141hGene KnockoutGFP0
(0)

PLC δ1 CRISPR/Cas9 KO Plasmid (h)

sc-402474hGene KnockoutGFP0
(0)

PLC γ1 Double Nickase Plasmid (h)

sc-400472-NIChGene KnockoutPuromycin
1
(0)

PLC γ1 Double Nickase Plasmid (h2)

sc-400472-NIC-2hGene KnockoutPuromycin
1
(0)

PLC-XD1 CRISPR/Cas9 KO Plasmid (m)

sc-436516mGene KnockoutGFP0
(0)

PLC-XD1 HDR Plasmid (m)

sc-436516-HDRmHomology Directed RepairPuromycin0
(0)

PLC β2 CRISPR/Cas9 KO Plasmid (h)

sc-400984hGene KnockoutGFP0
(0)

PLC η2 CRISPR/Cas9 KO Plasmid (h)

sc-409214hGene KnockoutGFP0
(0)

PLC γ2 CRISPR/Cas9 KO Plasmid (h)

sc-400451hGene KnockoutGFP0
(0)

PLC γ2 HDR Plasmid (h)

sc-400451-HDRhHomology Directed RepairPuromycin0
(0)

PLC β3 CRISPR/Cas9 KO Plasmid (h)

sc-401181hGene KnockoutGFP0
(0)

PLC β3 CRISPR/Cas9 KO Plasmid (m)

sc-422295mGene KnockoutGFP0
(0)

PLC β3 HDR Plasmid (m)

sc-422295-HDRmHomology Directed RepairPuromycin0
(0)

PLC δ4 CRISPR/Cas9 KO Plasmid (h)

sc-405761hGene KnockoutGFP0
(0)

PLC δ4 HDR Plasmid (h)

sc-405761-HDRhHomology Directed RepairPuromycin0
(0)

PLC CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

PLC ζ CRISPR Activation Plasmid (h)

sc-403348-ACThGene ActivationPuro, Blast, Hygro0
(0)

PLC β1 CRISPR Activation Plasmid (h)

sc-401141-ACThGene ActivationPuro, Blast, Hygro0
(0)

PLC γ1 CRISPR Activation Plasmid (h)

sc-400472-ACThGene ActivationPuro, Blast, Hygro
1
(0)

PLC γ1 Lentiviral Activation Particles (h)

sc-400472-LAChGene ActivationPuro, Blast, Hygro
1
(0)

PLC β2 CRISPR Activation Plasmid (h)

sc-400984-ACThGene ActivationPuro, Blast, Hygro0
(0)

PLC γ2 CRISPR Activation Plasmid (h)

sc-400451-ACThGene ActivationPuro, Blast, Hygro0
(0)

PLC γ2 Lentiviral Activation Particles (h)

sc-400451-LAChGene ActivationPuro, Blast, Hygro0
(0)

PLC β3 CRISPR Activation Plasmid (h)

sc-401181-ACThGene ActivationPuro, Blast, Hygro0
(0)

PLC siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

PLC δ siRNA (h)

sc-40843hGene SilencingN/A0
(0)

PLC δ shRNA Plasmid (h)

sc-40843-SHhGene SilencingPuromycin0
(0)

PLC δ shRNA (h) Lentiviral Particles

sc-40843-VhGene SilencingPuromycin0
(0)

PLC δ siRNA (m)

sc-40844mGene SilencingN/A0
(0)

PLC δ shRNA Plasmid (m)

sc-40844-SHmGene SilencingPuromycin0
(0)

PLC δ shRNA (m) Lentiviral Particles

sc-40844-VmGene SilencingPuromycin0
(0)

PLC ε siRNA (h)

sc-44024hGene SilencingN/A
5
(1)

PLC ε shRNA Plasmid (h)

sc-44024-SHhGene SilencingPuromycin
5
(1)

PLC ε shRNA (h) Lentiviral Particles

sc-44024-VhGene SilencingPuromycin
5
(1)

PLC ε siRNA (m)

sc-152295mGene SilencingN/A0
(0)

PLC ε shRNA Plasmid (m)

sc-152295-SHmGene SilencingPuromycin0
(0)

PLC ε shRNA (m) Lentiviral Particles

sc-152295-VmGene SilencingPuromycin0
(0)

PLC ε siRNA (r)

sc-270253rGene SilencingN/A0
(0)

PLC ε shRNA Plasmid (r)

sc-270253-SHrGene SilencingPuromycin0
(0)

PLC ε shRNA (r) Lentiviral Particles

sc-270253-VrGene SilencingPuromycin0
(0)

PLC ζ siRNA (h)

sc-95901hGene SilencingN/A0
(0)

PLC ζ shRNA Plasmid (h)

sc-95901-SHhGene SilencingPuromycin0
(0)

PLC ζ shRNA (h) Lentiviral Particles

sc-95901-VhGene SilencingPuromycin0
(0)

PLC ζ siRNA (m)

sc-152298mGene SilencingN/A0
(0)

PLC ζ shRNA Plasmid (m)

sc-152298-SHmGene SilencingPuromycin0
(0)

PLC ζ shRNA (m) Lentiviral Particles

sc-152298-VmGene SilencingPuromycin0
(0)

PLC-L siRNA (h)

sc-40845hGene SilencingN/A0
(0)

PLC-L shRNA Plasmid (h)

sc-40845-SHhGene SilencingPuromycin0
(0)

PLC-L shRNA (h) Lentiviral Particles

sc-40845-VhGene SilencingPuromycin0
(0)

PLC β1 siRNA (h)

sc-36266hGene SilencingN/A
3
(0)

PLC β1 shRNA Plasmid (h)

sc-36266-SHhGene SilencingPuromycin
3
(0)

PLC β1 shRNA (h) Lentiviral Particles

sc-36266-VhGene SilencingPuromycin
3
(0)

PLC β1 siRNA (m)

sc-36267mGene SilencingN/A
1
(0)

PLC β1 shRNA Plasmid (m)

sc-36267-SHmGene SilencingPuromycin
1
(0)

PLC β1 shRNA (m) Lentiviral Particles

sc-36267-VmGene SilencingPuromycin
1
(0)

PLC β1 siRNA (r)

sc-270424rGene SilencingN/A
1
(0)

PLC β1 shRNA Plasmid (r)

sc-270424-SHrGene SilencingPuromycin
1
(0)

PLC β1 shRNA (r) Lentiviral Particles

sc-270424-VrGene SilencingPuromycin
1
(0)

PLC δ1 siRNA (h)

sc-40841hGene SilencingN/A
2
(0)

PLC δ1 shRNA Plasmid (h)

sc-40841-SHhGene SilencingPuromycin
2
(0)

PLC δ1 shRNA (h) Lentiviral Particles

sc-40841-VhGene SilencingPuromycin
2
(0)

PLC δ1 siRNA (m)

sc-40842mGene SilencingN/A0
(0)

PLC δ1 shRNA Plasmid (m)

sc-40842-SHmGene SilencingPuromycin0
(0)

PLC δ1 shRNA (m) Lentiviral Particles

sc-40842-VmGene SilencingPuromycin0
(0)

PLC η1 siRNA (h)

sc-77989hGene SilencingN/A0
(0)

PLC η1 shRNA Plasmid (h)

sc-77989-SHhGene SilencingPuromycin0
(0)

PLC η1 shRNA (h) Lentiviral Particles

sc-77989-VhGene SilencingPuromycin0
(0)

PLC η1 siRNA (m)

sc-152302mGene SilencingN/A0
(0)

PLC η1 shRNA Plasmid (m)

sc-152302-SHmGene SilencingPuromycin0
(0)

PLC η1 shRNA (m) Lentiviral Particles

sc-152302-VmGene SilencingPuromycin0
(0)

PLC γ1 siRNA (h)

sc-29452hGene SilencingN/A
13
(0)

PLC γ1 shRNA Plasmid (h)

sc-29452-SHhGene SilencingPuromycin
13
(0)

PLC γ1 shRNA (h) Lentiviral Particles

sc-29452-VhGene SilencingPuromycin
13
(0)

PLC γ1 siRNA (m)

sc-36265mGene SilencingN/A
2
(0)

PLC γ1 shRNA Plasmid (m)

sc-36265-SHmGene SilencingPuromycin
2
(0)

PLC γ1 shRNA (m) Lentiviral Particles

sc-36265-VmGene SilencingPuromycin
2
(0)

PLC-XD1 siRNA (h)

sc-91576hGene SilencingN/A0
(0)

PLC-XD1 shRNA Plasmid (h)

sc-91576-SHhGene SilencingPuromycin0
(0)

PLC-XD1 shRNA (h) Lentiviral Particles

sc-91576-VhGene SilencingPuromycin0
(0)

PLC-XD1 siRNA (m)

sc-152299mGene SilencingN/A0
(0)

PLC-XD1 shRNA Plasmid (m)

sc-152299-SHmGene SilencingPuromycin0
(0)

PLC-XD1 shRNA (m) Lentiviral Particles

sc-152299-VmGene SilencingPuromycin0
(0)

PLC β2 siRNA (h)

sc-36270hGene SilencingN/A
2
(0)

PLC β2 shRNA Plasmid (h)

sc-36270-SHhGene SilencingPuromycin
2
(0)

PLC β2 shRNA (h) Lentiviral Particles

sc-36270-VhGene SilencingPuromycin
2
(0)

PLC β2 siRNA (m)

sc-36271mGene SilencingN/A
1
(0)

PLC β2 shRNA Plasmid (m)

sc-36271-SHmGene SilencingPuromycin
1
(0)

PLC β2 shRNA (m) Lentiviral Particles

sc-36271-VmGene SilencingPuromycin
1
(0)

PLC ε2 siRNA (h)

sc-77971hGene SilencingN/A0
(0)

PLC ε2 shRNA Plasmid (h)

sc-77971-SHhGene SilencingPuromycin0
(0)

PLC ε2 shRNA (h) Lentiviral Particles

sc-77971-VhGene SilencingPuromycin0
(0)

PLC ε2 siRNA (m)

sc-152296mGene SilencingN/A0
(0)

PLC ε2 shRNA Plasmid (m)

sc-152296-SHmGene SilencingPuromycin0
(0)

PLC ε2 shRNA (m) Lentiviral Particles

sc-152296-VmGene SilencingPuromycin0
(0)

PLC η2 siRNA (h)

sc-88680hGene SilencingN/A0
(0)

PLC η2 shRNA Plasmid (h)

sc-88680-SHhGene SilencingPuromycin0
(0)

PLC η2 shRNA (h) Lentiviral Particles

sc-88680-VhGene SilencingPuromycin0
(0)

PLC η2 siRNA (m)

sc-152297mGene SilencingN/A0
(0)

PLC η2 shRNA Plasmid (m)

sc-152297-SHmGene SilencingPuromycin0
(0)

PLC η2 shRNA (m) Lentiviral Particles

sc-152297-VmGene SilencingPuromycin0
(0)

PLC γ2 siRNA (h)

sc-36268hGene SilencingN/A
2
(0)

PLC γ2 shRNA Plasmid (h)

sc-36268-SHhGene SilencingPuromycin
2
(0)

PLC γ2 shRNA (h) Lentiviral Particles

sc-36268-VhGene SilencingPuromycin
2
(0)

PLC γ2 siRNA (m)

sc-36269mGene SilencingN/A0
(0)

PLC γ2 shRNA Plasmid (m)

sc-36269-SHmGene SilencingPuromycin0
(0)

PLC γ2 shRNA (m) Lentiviral Particles

sc-36269-VmGene SilencingPuromycin0
(0)

PLC-XD2 siRNA (h)

sc-78111hGene SilencingN/A0
(0)

PLC-XD2 shRNA Plasmid (h)

sc-78111-SHhGene SilencingPuromycin0
(0)

PLC-XD2 shRNA (h) Lentiviral Particles

sc-78111-VhGene SilencingPuromycin0
(0)

PLC β3 siRNA (h)

sc-36272hGene SilencingN/A
5
(0)

PLC β3 siRNA (h2)

sc-44321hGene SilencingN/A
1
(0)

PLC β3 shRNA Plasmid (h)

sc-36272-SHhGene SilencingPuromycin
5
(0)

PLC β3 shRNA Plasmid (h2)

sc-44321-SHhGene SilencingPuromycin
1
(0)

PLC β3 shRNA (h) Lentiviral Particles

sc-36272-VhGene SilencingPuromycin
5
(0)

PLC β3 shRNA (h2) Lentiviral Particles

sc-44321-VhGene SilencingPuromycin
1
(0)

PLC β3 siRNA (m)

sc-36273mGene SilencingN/A
1
(0)

PLC β3 shRNA Plasmid (m)

sc-36273-SHmGene SilencingPuromycin
1
(0)

PLC β3 shRNA (m) Lentiviral Particles

sc-36273-VmGene SilencingPuromycin
1
(0)

PLC β3 siRNA (r)

sc-156124rGene SilencingN/A0
(0)

PLC β3 shRNA (r) Lentiviral Particles

sc-156124-VrGene SilencingPuromycin0
(0)

PLC β3 shRNA shRNA Plasmid (r)

sc-156124-SHrGene SilencingPuromycin0
(0)

PLC δ3 siRNA (m)

sc-155939mGene SilencingN/A0
(0)

PLC δ3 shRNA Plasmid (m)

sc-155939-SHmGene SilencingPuromycin0
(0)

PLC δ3 shRNA (m) Lentiviral Particles

sc-155939-VmGene SilencingPuromycin0
(0)

PLC-XD3 siRNA (h)

sc-91727hGene SilencingN/A0
(0)

PLC-XD3 shRNA Plasmid (h)

sc-91727-SHhGene SilencingPuromycin0
(0)

PLC-XD3 shRNA (h) Lentiviral Particles

sc-91727-VhGene SilencingPuromycin0
(0)

PLC-XD3 siRNA (m)

sc-152301mGene SilencingN/A0
(0)

PLC-XD3 shRNA Plasmid (m)

sc-152301-SHmGene SilencingPuromycin0
(0)

PLC-XD3 shRNA (m) Lentiviral Particles

sc-152301-VmGene SilencingPuromycin0
(0)

PLC β4 siRNA (h)

sc-36274hGene SilencingN/A
1
(0)

PLC β4 shRNA Plasmid (h)

sc-36274-SHhGene SilencingPuromycin
1
(0)

PLC β4 shRNA (h) Lentiviral Particles

sc-36274-VhGene SilencingPuromycin
1
(0)

PLC β4 siRNA (m)

sc-36275mGene SilencingN/A
1
(0)

PLC β4 shRNA Plasmid (m)

sc-36275-SHmGene SilencingPuromycin
1
(0)

PLC β4 shRNA (m) Lentiviral Particles

sc-36275-VmGene SilencingPuromycin
1
(0)

PLC δ4 siRNA (h)

sc-45853hGene SilencingN/A0
(0)

PLC δ4 shRNA Plasmid (h)

sc-45853-SHhGene SilencingPuromycin0
(0)

PLC δ4 shRNA (h) Lentiviral Particles

sc-45853-VhGene SilencingPuromycin0
(0)

PLC δ4 siRNA (m)

sc-45854mGene SilencingN/A0
(0)

PLC δ4 shRNA Plasmid (m)

sc-45854-SHmGene SilencingPuromycin0
(0)

PLC δ4 shRNA (m) Lentiviral Particles

sc-45854-VmGene SilencingPuromycin0
(0)