PLC β4 Antibody (E-1): sc-166132

PLC β4 Antibody (E-1) is a mouse monoclonal IgG2a antibody that detects phosphoinositide-specific phospholipase C β4 (PLC β4) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLC β4 is a crucial enzyme involved in the phosphoinositide signaling pathway, which plays a significant role in various cellular processes, including cell growth, differentiation, and apoptosis. PLC β4 is primarily located in the cytoplasm and plasma membrane, where PLC β4 participates in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol. The generation of these second messengers is vital for propagating signals from activated receptors, thereby influencing downstream signaling cascades that regulate essential cellular functions. Notably, PLC β4 is distinct among the PLC isozymes due to unique regulatory mechanisms, which involve interactions with specific G protein subunits, allowing for precise control of activity in response to extracellular signals. Anti-PLC β4 antibody (E-1) is an invaluable tool for researchers studying the intricate roles of phospholipase C in cellular signaling and its implications in various physiological and pathological processes.

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PLC β4 Antibody (E-1) References:

1. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving G alpha q and phospholipase C beta 4.  |  Hashimoto, K., et al. 2000. Prog Brain Res. 124: 31-48. PMID: 10943115
2. Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells.  |  Min, DS., et al. 2000. Neurosci Lett. 292: 9-12. PMID: 10996437
3. Bradykinin, but not muscarinic, inhibition of M-current in rat sympathetic ganglion neurons involves phospholipase C-beta 4.  |  Haley, JE., et al. 2000. J Neurosci. 20: RC105. PMID: 11050147
4. Phospholipase C beta 4 in mouse hepatocytes: rhythmic expression and cellular distribution.  |  Klein, BM., et al. 2008. Comp Hepatol. 7: 8. PMID: 18957089
5. Heterogeneity of mutational mechanisms and modes of inheritance in auriculocondylar syndrome.  |  Gordon, CT., et al. 2013. J Med Genet. 50: 174-86. PMID: 23315542
6. Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation.  |  Kakiuchi, T., et al. 2016. Carcinogenesis. 37: 1098-1109. PMID: 27559111
7. Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.  |  Hong, J., et al. 2020. Sci Rep. 10: 8813. PMID: 32483199
8. Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.  |  Sasai, M., et al. 2021. J Exp Med. 218: PMID: 33970189
9. Melanopsin Signaling Pathway in HEK293 Cell Line with Stable Expression of Human Melanopsin: Possible Participation of Phospholipase C beta 4 and Diacylglycerol.  |  Krzysztynska-Kuleta, OI., et al. 2021. Photochem Photobiol. 97: 1136-1144. PMID: 33977551
10. Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis.  |  Phan, HTN., et al. 2021. Sci Signal. 14: eabj4243. PMID: 34905385

The preferred PLC β4 antibody is PLC β4 Antibody (A-8): sc-166131.