PLC β4 Antibody (D-7): sc-166133

PLC β4 Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects phosphoinositide-specific phospholipase C β4 (PLC β4) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLC β4 plays a pivotal role in cellular signaling by hydrolyzing phosphatidylinositol 4, 5-bisphosphate to generate second messengers inositol 1, 4, 5-triphosphate and diacylglycerol, which are crucial for various physiological processes, including cell proliferation, differentiation, and apoptosis. PLC β4 is primarily localized in the cytoplasm and plasma membrane, where PLC β4 interacts with various receptors and signaling molecules, thereby influencing downstream signaling pathways. The unique structural features of PLC β4, including SH2 and SH3 domains, allow activation by specific protein tyrosine kinases, which further underscores PLC β4′s importance in receptor-mediated signal transduction. Anti-PLC β4 antibody (D-7)′s specificity and sensitivity make this reagent an invaluable tool for researchers studying the intricate mechanisms of cell signaling and PLC β4′s role in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PLC β4 Antibody (D-7) References:

1. Quantification of relative mRNA expression in the rat brain using simple RT-PCR and ethidium bromide staining.  |  Horikoshi, T. and Sakakibara, M. 2000. J Neurosci Methods. 99: 45-51. PMID: 10936641
2. Fine mapping of the GLC1K juvenile primary open-angle glaucoma locus and exclusion of candidate genes.  |  Sud, A., et al. 2008. Mol Vis. 14: 1319-26. PMID: 18648523
3. mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.  |  Liu, JX., et al. 2008. Epilepsy Res. 82: 111-23. PMID: 18774262
4. Comparison of long noncoding RNA and mRNA expression profiles in mesenchymal stem cells derived from human periodontal ligament and bone marrow.  |  Dong, R., et al. 2014. Biomed Res Int. 2014: 317853. PMID: 24790996
5. The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture.  |  Hong, J., et al. 2016. Mol Brain. 9: 100. PMID: 27998287
6. Rosiglitazone Inhibits Angiotensin II-Induced Proliferation of Glomerular Mesangial Cells via the Gαq/Plcβ4/TRPC Signaling Pathway.  |  Wei, L., et al. 2017. Cell Physiol Biochem. 44: 2228-2242. PMID: 29258063
7. Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.  |  Hou, C., et al. 2020. Ophthalmic Res. 63: 358-368. PMID: 31614358
8. Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma.  |  Piaggio, F., et al. 2019. Cancers (Basel). 11: PMID: 31671564
9. In vitro suppression of porcine epidemic diarrhea virus by Panax notoginseng saponins: assessing antiviral potential.  |  Hu, Y., et al. 2024. Arch Virol. 169: 89. PMID: 38565720
10. Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.  |  Amson, RB., et al. 1996. Proc Natl Acad Sci U S A. 93: 3953-7. PMID: 8632996

The preferred PLC β4 antibody is PLC β4 Antibody (A-8): sc-166131.