PLC β3 Antibody (H-1): sc-271372

PLC β3 Antibody (H-1) is a mouse monoclonal IgG2a antibody that detects phosphoinositide-specific phospholipase C β3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLC β3 plays a pivotal role in cellular signaling by catalyzing the hydrolysis of phosphatidylinositol 4, 5-bisphosphate to generate the second messengers inositol 1, 4, 5-triphosphate and diacylglycerol, which are crucial for various physiological processes, including cell proliferation, differentiation, and apoptosis. The unique structure of PLC β3, which includes specific domains that allow for interaction with protein tyrosine kinases, enables activation in response to growth factor signaling, thereby influencing downstream signaling pathways. Additionally, PLC β3 is one of the γ-type isozymes, which are distinguished by SH2 and SH3 domains, allowing for a more complex regulatory mechanism compared to other PLC isozymes. The ability of PLC β3 to integrate signals from multiple pathways underscores its importance in maintaining cellular homeostasis and responding to external stimuli, making PLC β3 a valuable target for research in signal transduction and related diseases. Anti-PLC β3 antibody (H-1) is an essential tool for researchers aiming to explore the intricate roles of this enzyme in various biological contexts.

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PLC β3 Antibody (H-1) References:

1. The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal.  |  Hwang, JI., et al. 2005. J Biol Chem. 280: 12467-73. PMID: 15632121
2. Phospholipase C-beta3 mediates the thrombin-induced Ca2+ response in glial cells.  |  Hwang, JI., et al. 2005. Mol Cells. 19: 375-81. PMID: 15995354
3. Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase C.  |  Frecker, H., et al. 2005. Am J Physiol Renal Physiol. 289: F1078-87. PMID: 15998840
4. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.  |  Wang, Z., et al. 2008. J Clin Invest. 118: 195-204. PMID: 18079968
5. Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses.  |  Kremer, KN., et al. 2011. J Immunol. 187: 1440-7. PMID: 21705626
6. Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation.  |  Yasudo, H., et al. 2011. PLoS One. 6: e24995. PMID: 21949826
7. Intrathecal PLC(β3) oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance.  |  Quanhong, Z., et al. 2012. Brain Res. 1472: 38-44. PMID: 22771399
8. Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway.  |  Wu, J., et al. 2019. Mol Med Rep. 19: 573-580. PMID: 30431106
9. Localization of phospholipase C β3 in the major salivary glands of adult mice.  |  Rawangwong, A., et al. 2019. Acta Histochem. 121: 484-490. PMID: 31003695
10. Sinapine targeting PLCβ3 EF hands disrupts Gαq-PLCβ3 interaction and ameliorates cardiovascular diseases.  |  Chu, S., et al. 2024. Phytomedicine. 126: 155200. PMID: 38387273

The preferred PLC β3 antibody is PLC β3 Antibody (D-7): sc-133231.