PLC δ1 Antibody (D-7): sc-393464

PLC δ1 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects PLC delta 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLC δ1 (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PLC delta 1 protein plays a pivotal role in cellular signaling by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate second messengers inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), which are crucial for the activation of various signaling pathways. PLC delta 1 is particularly important in neuronal signaling and cardiovascular function, as PLC delta 1 amplifies calcium signals and modulates the activity of GTP-binding proteins involved in receptor signaling. PLC delta 1 is highly expressed in the brain, heart, lung, and testis, and abnormal PLC delta 1 accumulation has been observed in the brains of individuals with Alzheimer′s disease, indicating a potential role in the disease′s pathology. Additionally, PLC delta 1 interacts with several other proteins, including transglutaminase II, which is involved in oxytocin receptor and α1B-adrenoreceptor signaling, highlighting PLC delta 1′s significance in various physiological processes.

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PLC δ1 Antibody (D-7) References:

1. Molecular cloning and expression analysis of a mouse phospholipase C-delta1.  |  Lee, WK., et al. 1999. Biochem Biophys Res Commun. 261: 393-9. PMID: 10425196
2. Phospholipase Cdelta1 is a guanine nucleotide exchanging factor for transglutaminase II (Galpha h) and promotes alpha 1B-adrenoreceptor-mediated GTP binding and intracellular calcium release.  |  Baek, KJ., et al. 2001. J Biol Chem. 276: 5591-7. PMID: 11087745
3. Downregulation of phospholipase C delta3 by cAMP and calcium.  |  Lin, FG., et al. 2001. Biochem Biophys Res Commun. 286: 274-80. PMID: 11500033
4. Phospholipase C delta2 expression characterizes the neoplastic transformation of the human gastric mucosa.  |  Marchisio, M., et al. 2001. Am J Pathol. 159: 803-8. PMID: 11549571
5. Regulation of inositol phospholipid-specific phospholipase C isozymes.  |  Rhee, SG. and Choi, KD. 1992. J Biol Chem. 267: 12393-6. PMID: 1319994
6. A second gene product of the inositol-phospholipid-specific phospholipase C delta subclass.  |  Meldrum, E., et al. 1991. Eur J Biochem. 196: 159-65. PMID: 1848183
7. A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity.  |  Emori, Y., et al. 1989. J Biol Chem. 264: 21885-90. PMID: 2557343
8. Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.  |  Suh, PG., et al. 1988. Proc Natl Acad Sci U S A. 85: 5419-23. PMID: 2840660
9. Cloning of cDNA encoding rat phospholipase C-beta 4, a new member of the phospholipase C.  |  Kim, MJ., et al. 1993. Biochem Biophys Res Commun. 194: 706-12. PMID: 7688223
10. Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.  |  Jhon, DY., et al. 1993. J Biol Chem. 268: 6654-61. PMID: 8454637
11. Changes in platelet phospholipase C protein level and activity in Alzheimer's disease.  |  Matsushima, H., et al. 1995. Neurobiol Aging. 16: 895-900. PMID: 8622779
12. Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector.  |  Park, ES., et al. 1998. Biochem J. 331 (Pt 1): 283-9. PMID: 9512491

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PLC δ1 Antibody (D-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-PLC δ1 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PLC δ1 Antibody (D-7) Specifications

Alternate Product Name: PLC δ1

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 71-92

Epitope Target: PLC δ1

Epitope Species: human

Product Reactivity/Detection: PLC δ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for PLC δ1 Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin