PLC β4 Antibody (56): sc-136041
- PLC β4 Antibody (56) is a mouse monoclonal IgG1 provided at 50 µg/500 µl
- raised against amino acids 752-961 of PLC β4 of human origin
- recommended for detection of PLC β4 of mouse, rat, human and Drosophila origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PLC β4 Antibody (56). This work is in progress.
PLC β4 Antibody (56) is a mouse monoclonal IgG1 antibody that detects phosphoinositide-specific phospholipase C β4 (PLC β4) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PLC β4 plays a pivotal role in cellular signaling by hydrolyzing phosphatidylinositol 4, 5-bisphosphate to generate the second messengers inositol 1, 4, 5-triphosphate and diacylglycerol, which are crucial for various physiological processes, including cell growth, differentiation, and apoptosis. PLC β4 is primarily localized in the cytoplasm and is involved in the regulation of calcium signaling pathways, which are essential for muscle contraction and neurotransmitter release. The unique structural features of PLC β4, including specific domains that interact with G protein subunits, allow selective activation in response to extracellular signals, thereby influencing downstream signaling cascades. PLC β4 is known to interact with various proteins, including receptor tyrosine kinases, which further underscores PLC β4′s importance in mediating complex signaling networks within the cell. Anti-PLC β4 antibody (56) is an invaluable tool for researchers studying cellular communication and its implications in health and disease.
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PLC β4 Antibody (56) References:
- Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. | Smits, SM., et al. 2005. Neuroscience. 136: 171-9. PMID: 16198487
- Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors. | Shin, J., et al. 2009. J Neurosci. 29: 15375-85. PMID: 20007462
- SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis. | Chen, X., et al. 2022. Cell Death Differ. 29: 337-350. PMID: 34465891
- PLCβ4 driven by cadmium-exposure during gestation and lactation contributes to cognitive deficits by suppressing PIP2/PLCγ1/CREB/BDNF signaling pathway in male offspring. | Wang, Y., et al. 2024. J Hazard Mater. 474: 134756. PMID: 38820747
- Cerebellar Molecular Signatures in Non-Human Primates. | Yamamoto, T., et al. 2024. J Comp Neurol. 532: e25678. PMID: 39439015
- Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subunit of Gq. | Lee, CW., et al. 1994. J Biol Chem. 269: 25335-8. PMID: 7929227
- Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins. | Jiang, H., et al. 1994. J Biol Chem. 269: 7593-6. PMID: 8125982
- Purification, molecular cloning, and sequencing of phospholipase C-beta 4. | Lee, CW., et al. 1993. J Biol Chem. 268: 21318-27. PMID: 8407970
- The rat phospholipase C beta 4 gene is expressed at high abundance in cerebellar Purkinje cells. | Roustan, P., et al. 1995. Neuroreport. 6: 1837-41. PMID: 8547579
- Phospholipase C beta 4 is involved in modulating the visual response in mice. | Jiang, H., et al. 1996. Proc Natl Acad Sci U S A. 93: 14598-601. PMID: 8962098
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLC β4 Antibody (56) | sc-136041 | 50 µg/500 µl | $322.00 |