Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor-mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate. There are several mammalian PLC proteins, including PLC β1, PLC β2, PLC β3, PLC β4, PLCγ1, PLCγ2, PLC δ1, PLC δ3, PLC δ4 and PLCe. PLC δ1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and functions as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. PLC δ1 is highly expressed in brain, heart, lung and testis and is abnormally accumulated in autopsied brains with Alzheimer′s disease (AD), suggesting that it may play a role in the pathology of AD. Both PLC δ3 and PLC δ4 contain several functional domains through which they bind calcium as a cofactor and catalyze the creation of DAG and IP3, playing an essential role in signal transduction. PLC δ4 is highly expressed in skeletal muscle and kidney tissue, as well as in corneal epithelial cells, suggesting a role in the regulation of kidney and ocular function.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.