p-PLC γ1 Antibody (pY783.27): sc-136186

p-PLC γ1 Antibody (pY783.27) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Tyr 783 phosphorylated PLC γ1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). anti-p-PLC γ1 antibody (pY783.27) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. Phospholipase C-gamma 1 (PLC γ1) plays a crucial role in cellular signaling, particularly in hormonal signal transduction pathways, where PLC γ1 acts as a key mediator in the activation of downstream signaling cascades. The phosphorylation of PLC γ1 at Tyrosine 783 is particularly significant, as phosphorylation occurs just downstream of the kinase domain and is part of a sequence motif characteristic of the Trk family of protein-tyrosine kinase receptors. This specific phosphorylation event enhances the enzymatic activity of PLC γ1 and facilitates interaction with other signaling proteins, thereby amplifying the cellular response to growth factors. PLC γ1′s ability to form complexes with receptors such as TrkB underscores its importance in neurotrophic signaling and highlights potential as a therapeutic target in conditions where these pathways are dysregulated.

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p-PLC γ1 Antibody (pY783.27) References:

1. Growth factor phosphorylation of PLC-gamma 1.  |  Carpenter, G., et al. 1992. Ciba Found Symp. 164: 223-33; discussion 233-9. PMID: 1395933
2. Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact Hsc-1 cells.  |  Wahl, MI., et al. 1990. J Biol Chem. 265: 3944-8. PMID: 1689311
3. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.  |  Kim, HK., et al. 1991. Cell. 65: 435-41. PMID: 1708307
4. Thromboxane-induced contractile response of human coronary arterioles is diminished after cardioplegic arrest.  |  Feng, J., et al. 2011. Ann Thorac Surg. 92: 829-36. PMID: 21871266
5. The role of phospholipase Cγ1 in breast cancer and its clinical significance.  |  Emmanouilidi, A., et al. 2017. Future Oncol. 13: 1991-1997. PMID: 28829192
6. Tryptophan Ameliorates Barrier Integrity and Alleviates the Inflammatory Response to Enterotoxigenic Escherichia coli K88 Through the CaSR/Rac1/PLC-γ1 Signaling Pathway in Porcine Intestinal Epithelial Cells.  |  Liu, G., et al. 2021. Front Immunol. 12: 748497. PMID: 34745120
7. Associating bovine herpesvirus 1 envelope glycoprotein gD with activated phospho-PLC-γ1(S1248).  |  Liu, C., et al. 2023. Microbiol Spectr. 11: e0196323. PMID: 37655900
8. Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis.  |  Guiton, M., et al. 1994. J Biol Chem. 269: 30370-7. PMID: 7982951
9. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor.  |  Middlemas, DS., et al. 1994. J Biol Chem. 269: 5458-66. PMID: 8106527
10. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.  |  Law, CL., et al. 1996. Mol Cell Biol. 16: 1305-15. PMID: 8657103

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-PLC γ1 Antibody (pY783.27) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-p-PLC γ1 Antibody (pY783.27) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-PLC γ1 Antibody (pY783.27) Specifications

Alternate Product Name: PLC gamma

Product Clone Name: pY783.27

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Tyr 783

Epitope Target: PLC γ1

Epitope Species: human

Product Reactivity/Detection: Tyr 783 phosphorylated PLC γ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for p-PLC γ1 Antibody (pY783.27): N/A

The preferred PLC γ1 antibody is PLC γ1 Antibody (E-12): sc-7290.