PLC γ2 Antibody (A-3): sc-390389

PLC γ2 Antibody (A-3) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect the human Phospholipase C Gamma 2 (PLCγ2) protein, also known as PLC-gamma-2 or Phospholipase C Gamma 2. PLCγ2 monoclonal antibody (A-3) targets an epitope mapped to amino acids 935-971 within an internal region of human PLCγ2, ensuring precise binding and high specificity. PLCγ2 is an essential enzyme located primarily at the plasma membrane and within cytoplasmic signaling complexes, where PLCγ2 plays a crucial role in intracellular signal transduction by hydrolyzing phosphatidylinositol 4,5-bisphosphate to generate the second messengers inositol 1,4,5-triphosphate and diacylglycerol. These messengers are vital for processes such as calcium mobilization and the activation of protein kinase C, which are fundamental for immune cell function and response. The strategic cellular localization of PLCγ2 allows PLCγ2 to effectively participate in B cell receptor signaling and other immune-related pathways, making PLCγ2 a key player in maintaining immune system homeostasis. Anti-PLCγ2 antibody (A-3) exhibits broad species reactivity, recognizing PLCγ2 from mouse, rat, and human origins, as well as additional species including equine, canine, bovine, and porcine, across various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). This versatility makes PLCγ2 monoclonal antibody (A-3) an indispensable tool for researchers investigating signal transduction pathways and immune mechanisms. Available in both unconjugated form and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), and multiple Alexa Fluor® conjugates, PLCγ2 (A-3) antibody provides the flexibility needed to meet diverse experimental requirements.

The preferred PLC γ2 antibody is PLC γ2 Antibody (B-10): sc-5283.