Staphylococcus aureus TSST-1 Antibody (5): sc-73360

Staphylococcus aureus TSST-1 Antibody (5) is a mouse monoclonal IgG1 antibody that detects Staphylococcus aureus TSST-1 by western blotting (WB). Anti-TSST-1 antibody (5) is available as the non-conjugated format. Staphylococcus aureus is a Gram-positive coccus that commonly resides on human skin and in the nasal passages, and produces β-lactamase, an enzyme that degrades the β-lactam ring of penicillin, rendering resistance to many antibiotics. TSST-1, a potent exotoxin secreted by Staphylococcus aureus, is crucial in the pathogenesis of Toxic Shock Syndrome (TSS), as TSST-1 induces a massive immune response by binding non-specifically to major histocompatibility complex (MHC) class II molecules and T cell receptors, leading to polyclonal T cell activation. This mechanism contributes to severe symptoms of TSS, such as high fever, hypotension, and multi-organ failure, while playing a role in various autoimmune and allergic conditions linked to B cell hyperactivity. Understanding TSST-1 function is vital for developing therapeutic strategies against TSS and related diseases, as well as for improving antibiotic treatment protocols for Staphylococcus aureus infections.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Staphylococcus aureus TSST-1 Antibody (5) References:

1. The changing epidemiology of Staphylococcus aureus?  |  Chambers, HF. 2001. Emerg Infect Dis. 7: 178-82. PMID: 11294701
2. Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene.  |  Chang, S., et al. 2003. N Engl J Med. 348: 1342-7. PMID: 12672861
3. Prevalence of toxic shock syndrome toxin 1-producing Staphylococcus aureus and the presence of antibodies to this superantigen in menstruating women.  |  Parsonnet, J., et al. 2005. J Clin Microbiol. 43: 4628-34. PMID: 16145118
4. Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.  |  Buonpane, RA., et al. 2005. J Mol Biol. 353: 308-21. PMID: 16171815
5. Bacterial superantigen TSST-1 attenuates suppressive efficacy of glucocorticoids and calcineurin inhibitors against blastogenesis of peripheral blood mononuclear cells from patients with antineutrophil cytoplasmic antibody-associated vasculitis and nephrosis.  |  Hirano, T., et al. 2006. Int Immunopharmacol. 6: 924-34. PMID: 16644478
6. Neonatal staphylococcal scalded skin syndrome: massive outbreak due to an unusual phage type.  |  Curran, JP. and Al-Salihi, FL. 1980. Pediatrics. 66: 285-90. PMID: 6447271
7. Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis.  |  Hofer, MF., et al. 1996. Proc Natl Acad Sci U S A. 93: 5425-30. PMID: 8643591
8. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.  |  Hiramatsu, K., et al. 1997. J Antimicrob Chemother. 40: 135-6. PMID: 9249217
9. The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching.  |  Jabara, HH. and Geha, RS. 1996. Int Immunol. 8: 1503-10. PMID: 8921429