Date published: 2026-7-10

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SIRT CRISPR Plasmids

Santa Cruz Biotechnology, Inc. offers a broad range of gene editing products including CRISPR/Cas9 Knockout and CRISPR Double Nickase plasmids for gene silencing. SIRT gene silencers are available as SIRT CRISPR/Cas9 Knockout plasmids and SIRT Double Nickase Plasmids. SIRT CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation are also available. Gene silencers and activators are useful for gene studies in combination with antibodies used for protein detection.

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SIRT CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SIRT1 CRISPR/Cas9 KO Plasmid (h)

sc-400085Gene Knockouth0
(2)

SIRT4 CRISPR/Cas9 KO Plasmid (h)

sc-401187Gene Knockouth0
(0)

SIRT7 CRISPR/Cas9 KO Plasmid (h)

sc-401401Gene Knockouth0
(0)

SIRT6 CRISPR/Cas9 KO Plasmid (h)

sc-412216Gene Knockouth0
(1)

SIRT5 CRISPR/Cas9 KO Plasmid (h)

sc-416994Gene Knockouth0
(0)

SIRT2 CRISPR/Cas9 KO Plasmid (m)

sc-425703Gene Knockoutm0
(0)

SIRT5 CRISPR/Cas9 KO Plasmid (m)

sc-427028Gene Knockoutm0
(0)

SIRT7 CRISPR/Cas9 KO Plasmid (m)

sc-431608Gene Knockoutm0
(0)

SIRT3 CRISPR/Cas9 KO Plasmid (r)

sc-437315Gene Knockoutr0
(0)

SIRT4 CRISPR/Cas9 KO Plasmid (r)

sc-437316Gene Knockoutr0
(0)

SIRT5 CRISPR/Cas9 KO Plasmid (r)

sc-437317Gene Knockoutr0
(0)

SIRT1 HDR Plasmid (h)

sc-400085-HDRHomology Directed Repairh0
(2)

SIRT4 HDR Plasmid (h)

sc-401187-HDRHomology Directed Repairh0
(0)

SIRT7 HDR Plasmid (h)

sc-401401-HDRHomology Directed Repairh0
(0)

SIRT6 HDR Plasmid (h)

sc-412216-HDRHomology Directed Repairh0
(1)

SIRT5 HDR Plasmid (h)

sc-416994-HDRHomology Directed Repairh0
(0)

SIRT5 HDR Plasmid (m)

sc-427028-HDRHomology Directed Repairm0
(0)

SIRT7 HDR Plasmid (m)

sc-431608-HDRHomology Directed Repairm0
(0)

SIRT3 HDR Plasmid (r)

sc-437315-HDRHomology Directed Repairr0
(0)

SIRT4 HDR Plasmid (r)

sc-437316-HDRHomology Directed Repairr0
(0)

SIRT5 HDR Plasmid (r)

sc-437317-HDRHomology Directed Repairr0
(0)

SIRT2 CRISPR/Cas9 KO Plasmid (h2)

sc-400590-KO-2Gene Knockouth0
(1)

SIRT3 CRISPR/Cas9 KO Plasmid (h2)

sc-400675-KO-2Gene Knockouth0
(0)

SIRT6 CRISPR/Cas9 KO Plasmid (m2)

sc-424467-KO-2Gene Knockoutm0
(0)

SIRT3 CRISPR/Cas9 KO Plasmid (m2)

sc-425704-KO-2Gene Knockoutm0
(0)

SIRT1 CRISPR/Cas9 KO Plasmid (m2)

sc-430046-KO-2Gene Knockoutm0
(0)

SIRT2 HDR Plasmid (h2)

sc-400590-HDR-2Homology Directed Repairh0
(1)

SIRT3 HDR Plasmid (h2)

sc-400675-HDR-2Homology Directed Repairh0
(0)

SIRT6 HDR Plasmid (m2)

sc-424467-HDR-2Homology Directed Repairm0
(0)

SIRT3 HDR Plasmid (m2)

sc-425704-HDR-2Homology Directed Repairm0
(0)

SIRT1 HDR Plasmid (m2)

sc-430046-HDR-2Homology Directed Repairm0
(0)

SIRT CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SIRT1 Double Nickase Plasmid (h)

sc-400085-NICGene Knockouth0
(0)

SIRT2 Double Nickase Plasmid (h)

sc-400590-NICGene Knockouth0
(0)

SIRT3 Double Nickase Plasmid (h)

sc-400675-NICGene Knockouth0
(0)

SIRT4 Double Nickase Plasmid (h)

sc-401187-NICGene Knockouth0
(0)

SIRT6 Double Nickase Plasmid (h)

sc-412216-NICGene Knockouth0
(0)

SIRT5 Double Nickase Plasmid (h)

sc-416994-NICGene Knockouth0
(0)

SIRT6 Double Nickase Plasmid (m)

sc-424467-NICGene Knockoutm0
(0)

SIRT2 Double Nickase Plasmid (m)

sc-425703-NICGene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (m)

sc-425704-NICGene Knockoutm0
(0)

SIRT5 Double Nickase Plasmid (m)

sc-427028-NICGene Knockoutm0
(0)

SIRT1 Double Nickase Plasmid (m)

sc-430046-NICGene Knockoutm0
(0)

SIRT7 Double Nickase Plasmid (m)

sc-431608-NICGene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (r)

sc-437315-NICGene Knockoutr0
(0)

SIRT4 Double Nickase Plasmid (r)

sc-437316-NICGene Knockoutr0
(0)

SIRT5 Double Nickase Plasmid (r)

sc-437317-NICGene Knockoutr0
(0)

SIRT1 Double Nickase Plasmid (h2)

sc-400085-NIC-2Gene Knockouth0
(0)

SIRT2 Double Nickase Plasmid (h2)

sc-400590-NIC-2Gene Knockouth0
(0)

SIRT3 Double Nickase Plasmid (h2)

sc-400675-NIC-2Gene Knockouth0
(0)

SIRT4 Double Nickase Plasmid (h2)

sc-401187-NIC-2Gene Knockouth0
(0)

SIRT6 Double Nickase Plasmid (h2)

sc-412216-NIC-2Gene Knockouth0
(0)

SIRT5 Double Nickase Plasmid (h2)

sc-416994-NIC-2Gene Knockouth0
(0)

SIRT6 Double Nickase Plasmid (m2)

sc-424467-NIC-2Gene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (m2)

sc-425704-NIC-2Gene Knockoutm0
(0)

SIRT5 Double Nickase Plasmid (m2)

sc-427028-NIC-2Gene Knockoutm0
(0)

SIRT1 Double Nickase Plasmid (m2)

sc-430046-NIC-2Gene Knockoutm0
(0)

SIRT3 Double Nickase Plasmid (r2)

sc-437315-NIC-2Gene Knockoutr0
(0)

SIRT4 Double Nickase Plasmid (r2)

sc-437316-NIC-2Gene Knockoutr0
(0)

SIRT5 Double Nickase Plasmid (r2)

sc-437317-NIC-2Gene Knockoutr0
(0)

SIRT CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

SIRT1 CRISPR Activation Plasmid (h)

sc-400085-ACTGene Activationh0
(0)

SIRT3 CRISPR Activation Plasmid (h)

sc-400675-ACTGene Activationh0
(0)

SIRT4 CRISPR Activation Plasmid (h)

sc-401187-ACTGene Activationh0
(0)

SIRT7 CRISPR Activation Plasmid (h)

sc-401401-ACTGene Activationh0
(0)

SIRT5 CRISPR Activation Plasmid (h)

sc-416994-ACTGene Activationh0
(0)

SIRT6 CRISPR Activation Plasmid (m)

sc-424467-ACTGene Activationm0
(0)

SIRT3 CRISPR Activation Plasmid (m)

sc-425704-ACTGene Activationm0
(0)

SIRT1 CRISPR Activation Plasmid (m)

sc-430046-ACTGene Activationm0
(0)

SIRT1 CRISPR Activation Plasmid (h2)

sc-400085-ACT-2Gene Activationh0
(0)

SIRT3 CRISPR Activation Plasmid (h2)

sc-400675-ACT-2Gene Activationh0
(0)

SIRT7 CRISPR Activation Plasmid (h2)

sc-401401-ACT-2Gene Activationh0
(0)

SIRT5 CRISPR Activation Plasmid (h2)

sc-416994-ACT-2Gene Activationh0
(0)

SIRT6 CRISPR Activation Plasmid (m2)

sc-424467-ACT-2Gene Activationm0
(0)

SIRT1 CRISPR Activation Plasmid (m2)

sc-430046-ACT-2Gene Activationm0
(0)

SIRT1 Lentiviral Activation Particles (h)

sc-400085-LACGene Activationh0
(0)

SIRT3 Lentiviral Activation Particles (m)

sc-425704-LACGene Activationm0
(0)

SIRT1 Lentiviral Activation Particles (m)

sc-430046-LACGene Activationm0
(0)