Id1 Activators
The Id1 activators form a diverse array of chemicals that intricately modulate the activation of Inhibitor of DNA binding 1 (Id1), a transcription factor playing crucial roles in cellular processes, including differentiation, development, and disease progression. These activators primarily target key signaling pathways such as NF-κB, PI3K/Akt, p38 MAPK, and TGF-β, among others, showcasing the complexity of the regulatory networks governing Id1 expression. Curcumin, a natural compound with diverse biological activities, serves as an illustrative example of indirect Id1 activation by inhibiting the NF-κB pathway. Curcumin achieves this by suppressing the activity of p65, a subunit of NF-κB, thus relieving its inhibitory effect on Id1 transcription. This mechanism highlights the intricate interplay between transcription factors and their regulatory elements within the NF-κB pathway. LY294002, a PI3K/Akt pathway inhibitor, provides another perspective on Id1 activation. By disrupting the PI3K/Akt/GSK-3β pathway, LY294002 increases GSK-3β activity, leading to subsequent Id1 activation. This mode of action emphasizes the specificity of Id1 activation through targeted intervention in signaling cascades crucial for cellular processes.
The Rac1 inhibitor, NSC 23766, showcases the interconnected nature of cellular signaling pathways influencing Id1 activation. Inhibition of Rac1 leads to increased RhoA activity, subsequently activating ROCK. This activation alleviates the phosphorylation of Twist, a repressor of Id1, underscoring the cascade of events that can modulate Id1 expression through the RhoA/ROCK pathway. Furthermore, the Id1 activators exhibit specificity in their modes of action. Withaferin A, for instance, impacts the NF-κB pathway by inhibiting NF-κB, while SB431542 disrupts the TGF-β/Smad pathway by inhibiting the TGF-β receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenol found in turmeric, has been identified to indirectly activate Id1 through the inhibition of the NF-κB signaling pathway. By suppressing NF-κB, curcumin reduces the expression of Id1's negative regulator, resulting in increased Id1 activity. This occurs through the downregulation of p65, a subunit of NF-κB, which normally represses Id1 transcription. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, indirectly activates Id1 by disrupting the PI3K/AKT pathway. As a downstream effector of PI3K, AKT regulates the GSK-3β pathway. By inhibiting PI3K, LY294002 suppresses AKT activation, leading to increased GSK-3β activity. Activated GSK-3β then phosphorylates and destabilizes Twist, a repressor of Id1. Consequently, the inhibition of PI3K by LY294002 indirectly supports Id1 activation by relieving Twist-mediated repression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 mitogen-activated protein kinase (MAPK) inhibitor, indirectly activates Id1 by modulating the p38 MAPK pathway. p38 MAPK negatively regulates Id1 through phosphorylation of Smad4. Inhibiting p38 MAPK with SB203580 prevents Smad4 phosphorylation, allowing Smad4 to bind with Smad2/3 and form a complex that activates Id1 transcription. Thus, SB203580 indirectly supports Id1 activation by blocking the inhibitory phosphorylation of Smad4 by p38 MAPK. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, indirectly activates Id1 by influencing the SIRT1/FoxO3a pathway. Resveratrol activates SIRT1, a histone deacetylase, which then deacetylates FoxO3a. Deacetylated FoxO3a translocates to the nucleus and enhances Id1 transcription. Therefore, resveratrol indirectly supports Id1 activation by promoting the SIRT1/FoxO3a pathway, leading to increased Id1 expression. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $66.00 $273.00 | 3 | |
LY303511, an Akt inhibitor, indirectly activates Id1 by disrupting the PI3K/Akt/GSK-3β pathway. Inhibition of Akt by LY303511 results in increased GSK-3β activity. Activated GSK-3β phosphorylates and destabilizes Twist, a negative regulator of Id1. Consequently, LY303511 indirectly supports Id1 activation by relieving Twist-mediated repression through the inhibition of Akt. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082, an inhibitor of NF-κB activation, indirectly activates Id1 by suppressing the NF-κB pathway. Inhibition of NF-κB by BAY 11-7082 reduces the expression of Id1's negative regulator, leading to increased Id1 activity. This occurs through the prevention of p65, a subunit of NF-κB, from repressing Id1 transcription. Consequently, BAY 11-7082 indirectly supports Id1 activation by blocking the inhibitory influence of p65 on Id1 expression through the inhibition of NF-κB. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542, an inhibitor of the TGF-β receptor, indirectly activates Id1 by disrupting the TGF-β/Smad pathway. Inhibition of the TGF-β receptor by SB431542 prevents Smad2/3 activation, allowing Smad4 to form a complex with Smad2/3 and activate Id1 transcription. Thus, SB431542 indirectly supports Id1 activation by blocking the inhibitory Smad2/3-mediated regulation of Id1 through the inhibition of the TGF-β receptor. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
NDGA, a natural phenolic compound, indirectly activates Id1 by modulating the PI3K/Akt pathway. NDGA inhibits PI3K, leading to decreased Akt activation. Reduced Akt activity results in increased GSK-3β activity. Activated GSK-3β phosphorylates and destabilizes Twist, a negative regulator of Id1. Consequently, NDGA indirectly supports Id1 activation by relieving Twist-mediated repression through the modulation of the PI3K/Akt pathway. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A, a steroidal lactone, indirectly activates Id1 by impacting the NF-κB pathway. Withaferin A inhibits NF-κB, reducing the expression of Id1's negative regulator. This occurs through the suppression of p65, a subunit of NF-κB, which normally represses Id1 transcription. Thus, Withaferin A indirectly supports Id1 activation by blocking the inhibitory influence of p65 on Id1 expression through the inhibition of NF-κB. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT, a γ-secretase inhibitor, indirectly activates Id1 by affecting the Notch signaling pathway. Inhibition of γ-secretase by DAPT prevents the cleavage of Notch, leading to decreased Notch intracellular domain (NICD) release. NICD normally inhibits Id1 expression. Therefore, DAPT indirectly supports Id1 activation by preventing NICD-mediated repression through the inhibition of γ-secretase and the modulation of the Notch signaling pathway. | ||||||