Molecular structure of LY 303511, CAS Number: 154447-38-8
LY 303511 (CAS 154447-38-8)
See product citations (3)
Alternate Names:
2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one
Application:
LY 303511 is a negative control for PI 3-kinase inhibitors
CAS Number:
154447-38-8
Purity:
>98%
Molecular Weight:
306.4
Molecular Formula:
C19H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 303511 is a cell-permeable chemical that exhibits antineoplastic actions independent of PI 3-kinase inhibition. LY 303511 was first discovered as an inactive analog of LY294002 (Catalog sc-215273) which does not inhibit PI 3-kinase, but recent research has shown LY 303511 to block cell proliferation via mTOR-dependent and independent mechanisms, without inducing apoptosis. LY 303511 may act to reduce G2M progression, G2M-specific cyclins and casein kinase 2 activity in A549 cells. It can be used as a negative control for the PI 3-kinase inhibitor LY294002.
LY 303511 (CAS 154447-38-8) References
- Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes. | McDowell, SA., et al. 2004. Am J Physiol Heart Circ Physiol. 286: H796-805. PMID: 14563664
- Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation. | Andersson, TP., et al. 2003. Cell Signal. 15: 1119-27. PMID: 14575867
- LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. | Choi, EK., et al. 2004. FEBS Lett. 559: 141-4. PMID: 14960322
- LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. | Kristof, AS., et al. 2005. J Pharmacol Exp Ther. 314: 1134-43. PMID: 15923340
- LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. | Poh, TW. and Pervaiz, S. 2005. Cancer Res. 65: 6264-74. PMID: 16024628
- Detailed molecular analysis of the induction of the L-PK gene by glucose. | Eckert, DT., et al. 2008. Biochem Biophys Res Commun. 372: 131-6. PMID: 18468514
- LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway. | Liu, P., et al. 2008. Biochem Biophys Res Commun. 377: 187-90. PMID: 18831964
- LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. | Shenoy, K., et al. 2009. Cancer Res. 69: 1941-50. PMID: 19223550
- Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate. | Pattnaik, BR. and Hughes, BA. 2009. Am J Physiol Cell Physiol. 297: C1001-11. PMID: 19641096
- Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP. | Shi, Y., et al. 2013. Bioinformatics. 29: 347-54. PMID: 23239672
- LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms. | Shepelev, MV., et al. 2013. Mol Pharm. 10: 931-9. PMID: 23373904
- Identification of a lncRNA based signature for pancreatic cancer survival to predict immune landscape and potential therapeutic drugs. | Ma, D., et al. 2022. Front Genet. 13: 973444. PMID: 36186449
- Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils. | Ding, J., et al. 1995. J Biol Chem. 270: 11684-91. PMID: 7744808
Inhibitor of:
αA-crystallin, β-defensin 20, β-defensin 9, 4921501E09Rik, C030048H21Rik, C230096C10Rik, C6orf150, C9orf69, CKR-7, D14Ertd668e, EPCR, GABARAPL2, GBP2, GP-39, HELB, ICAM-5, IP3KB, M13 Major Coat Protein, MER3, Microcephalin, Myelin P2, Olfr462, Olfr695, PGRMC1, PLA1A, Sprouty 4, and TTI1.Activator of:
14-3-3 γ, ATRIP, BTNL10, Btnl6, DAP10, FKHRL1, Id1, OTTMUSG00000016644, PALB2, pro-MCH, SDF-1, and SGK3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 303511, 1 mg | sc-202215 | 1 mg | $67.00 | |||
LY 303511, 5 mg | sc-202215A | 5 mg | $278.00 |