Molecular structure of DAPT, CAS Number: 208255-80-5
DAPT (CAS 208255-80-5)
See product citations (47)
Alternate Names:
Gamma-Secretase Inhibitor IX;N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
Application:
DAPT is a potent and specific inhibitor of γ-secretase
CAS Number:
208255-80-5
Purity:
≥95%
Molecular Weight:
432.46
Molecular Formula:
C23H26F2N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DAPT is a potent and specific inhibitor of gamma-secretase. It may act to cause a reduction in Abeta40 and Abeta42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Abeta40 and Abeta42 respectively). There is evidence that DAPT does not effect APPalpha and APPbeta levels. It mimics notch signaling deficiencies at morphological, molecular and biochemical levels and may act to block notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC).
DAPT (CAS 208255-80-5) References
- Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. | Dovey, HF., et al. 2001. J Neurochem. 76: 173-81. PMID: 11145990
- A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. | Geling, A., et al. 2002. EMBO Rep. 3: 688-94. PMID: 12101103
- The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice. | Lanz, TA., et al. 2003. J Pharmacol Exp Ther. 305: 864-71. PMID: 12626636
- Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. | Gowrishankar, K., et al. 2004. J Cell Sci. 117: 4099-111. PMID: 15280425
- Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. | De Smedt, M., et al. 2005. Blood. 106: 3498-506. PMID: 16030192
- Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. | El Mouedden, M., et al. 2006. Curr Pharm Des. 12: 671-6. PMID: 16472156
- Bleeding versus thrombosis: role of short DAPT in complex lesions. | Calcagno, S., et al. 2015. Minerva Cardioangiol. 63: 533-46. PMID: 26334115
- Short versus prolonged dual antiplatelet therapy (DAPT) duration after coronary stent implantation: A comparison between the DAPT study and 9 other trials evaluating DAPT duration. | Toyota, T., et al. 2017. PLoS One. 12: e0174502. PMID: 28931015
- ACC/AHA Versus ESC Guidelines on Dual Antiplatelet Therapy: JACC Guideline Comparison. | Capodanno, D., et al. 2018. J Am Coll Cardiol. 72: 2915-2931. PMID: 30522654
- Toward the Characterization of DAPT Interactions with γ-Secretase. | Aguayo-Ortiz, R., et al. 2019. ChemMedChem. 14: 1005-1010. PMID: 30925201
- Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial. | Watanabe, H., et al. 2019. JAMA. 321: 2414-2427. PMID: 31237644
- DAPT inhibits titanium particle-induced osteolysis by suppressing the RANKL/Notch2 signaling pathway. | Wei, X., et al. 2020. J Biomed Mater Res A. 108: 2150-2161. PMID: 32323420
- Dual Antiplatelet Therapy in Coronary Artery Disease. | Sharma, R., et al. 2020. Cardiol Ther. 9: 349-361. PMID: 32804330
- Validation of the 4-Item PRECISE-DAPT Score: A SWEDEHEART Study. | Wester, A., et al. 2021. J Am Heart Assoc. 10: e020974. PMID: 34612051
- DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis. | Yang, JY., et al. 2022. Front Pharmacol. 13: 902796. PMID: 35571137
Inhibitor of:
β-defensin 27, β-defensin 37, β-defensin 38, 1700011H14Rik, 2310002L09Rik, 2410012M07Rik, 2410066E13Rik, 4930451C15Rik, 4930511I11Rik, 4930544G11Rik, 4931429I11Rik, 4932411E22Rik, 6330545A04Rik, ADAM10, AIDA-1, ALX1, AMZ2, Ang-4, ANKRD33B, ANKRD43, Aph-1b, Aph-1c, APLP1, ARGFX, ARID3B, ASCL1, ASCL5, Barhl2, BOC, Bordetella pertussis, Borrelia burgdorferi Osp A, BR-cadherin, BTBD7, BY080835, C11orf41_D430041D05Rik, C12orf45, C15orf59, C16orf72, C16orf78, C17orf63, C17orf69, C17orf89, C19orf21, C19orf64, C1orf187, C1orf218, C1orf67, C20orf144, C20orf149, C20orf173, C20orf202, C20orf26, C20orf46, C230078M14Rik, C2CD4A, C330013F16Rik, C3orf34_1500031L02Rik, C78339, C86695, C9orf103, C9orf57, cadherin-24, cadherin-26, CASPR3, CASPR5, CASZ1, CBWD5, CCBE1, CCDC105, CCDC144NL, CD4, CDH20, CDRT15L1, CEACAM16, CEACAM3, Chox10, claudin-6, claudin-9, CLPTM1, CNTNAP3B, COL11A1, copine 2, COUP-TFI, Cripto-3, CRS4C-2, Crumbs, cryptdin 21, cryptdin 24, cryptdin 25, cryptdin 26, cryptdin 4, Csl, CTNNAL1, CXXC5, Cypt3, Cytokeratin 6E, D53, DCHS1, Deltex (DTX; E3 ubiquitin ligase), Dim2, DIP2B, DLK2, Dlx-2, DMRT2, DMRTA1, DPY19L1, DRG11, DXBay18, E. coli K99, E030019B06Rik, E330017A01Rik, ECAT1, Edwardsiella tarda, EG623186, EGFL3, EMX (Empty Spiracles Homeobox), ENHO, Esgp, FAM124A, Fe65, FHL-1, FLJ36848, FLRT1, Fmi2, FNDC3B, FOG-2, FOXC2, FOXD3, FOXD4, FOXD4L2, FOXD4L6, FOXF1, FRAS1, fringe, GABP-β2, Gamma-secretase, GATA-5, GBX1, GLIPR1L3, GLIS2, GLTSCR1, Gm12, Gm281, Gm765, GPNMB, GPR89C, GPRC5B, GXYLT2, H2-M3, Hairless, HATH-6, HB9, HEG1, HEPHL1, HES1, HES3, HES4, HES5, HES6, HES7, HIP3, Hmcn2, HNP-1, HoxA1, HOXA3, HoxA5, HoxB13, HoxC8, HoxD10, HoxD12, HoxD13, HoxD8, HRT1_Hrt1, IDE, ILT-6, INSM1, Integrin αE, IRX5, Islet-2, Jagged, Jagged1, KIAA1024L_A730017C20Rik, KIAA1462, KIAA1731, KRTAP16-9, Laminin β-4, LARP6, LBX2, LCORL, LHX1, LHX3, LHX6, LHX9, LIN-39, Lingo-2, Lingo-4, Lipid A, LMO4, LMX1B, LOC100041222, LOC100041230, LOC100041243, LOC100041263, LOC100041281, LOC100041354, LOC100041393, LOC130951, LOC150356, LOC285095, LOC339209, LOC388210, LOC388237, LOC391358, LOC440338, LOC635396, LOC647194, LOC653550, LOC728741, LOC728861, LOC729121, LOC729837, LRRC29, LRRC36, LRRFIP1, LRRN3, LRTM1, Ly-6A/E, M-cadherin, MAB-5, MAGE-C1, MAGI-1, Manic Fringe, MATH-1, MATH-2, MATH-3, MDFIC, MEGF11, MESP1, MGAT3, MKX, MOX-2, MRP-L1, MRP-L33, MRSA, MXL-1, Myosin 18B, N-twist, NBPF, NET-7, netrin-2_netrin-3, Neuralized-2, Neurexophilin-2, NEURL, Neuro D2, NHLRC2, NLE1, Nolz-1, NOPE, Notch, nov, Nrarp, NUMB, OC-2, Odf4, Olfr48, Olfr480, Olfr608, Olfr646, Olfr843, OLIG2, OR7A17, OSR2, otoancorin, Otolin-1, OTP, Pals2, Papilin, Pax-6, PAX9, PCDH8, PCDHAC, PCDHAC1_Pcdhac1, PCDHB1, PCDHB12, PCDHB16, Pcdhb19, PCDHB2, PCDHB4, PCDHB5, PCDHB7, PCDHGA3, Pecanex 1, Pecanex 2, Penumbra, PFAAP5, PION, Pitx2, POD-1, Podocan, Polycystin-L, PPDPF, PPIL5, Prickle1, Prickle2, proenkephalin A, PROX2, PRR16, pS2, PSAPL1, PTD015, PTF1, Radical Fringe, RAM, RBFOX3/NeuN, RBP-Jκ, RBP-L, Reelin, Reg γ, Reg 1α, RFX4, RGD1562043, Rhox2a, Rhox2b, Ripply1, Ripply2, robo2, RPRML, Salmonella (Enterobacterales), Salmonella O, Scleraxis, SCO-spondin, SCRG1, SCUBE1, SEL-12, SEMA3C, SEMA3D, SEMA3E, SEMA5A, SEMA6D, Semaphorin, SHOX, Sidekick-1, Sidekick-2, Six1, Six2, Six4, Six6, SKT, SLC35C2, Slit3, SLITRK2, SLUG, SMOC-1, Smuc, Sox-1, Sox-18, Sox-7, Sox19, SOXN, SPATA1, Spitz, SPPase2, SPPL2a, SPPL3, SRRT (Serrate), Stra8, Streptococcus Group B, Suppressor of Hairless, Syndecan-1, Tβ-4, T1-cadherin, TBX1, TBX6, TCF23, TEM5, Tenascin-N, Teneurin-2, Teneurin-3, Testican-2, THSD7B, TLE1, TLE2, TLE4, TLE5, TM7SF3, TMEM134, TMEM233, TMEM245, TMEM59, TMEM8C, TRNP-1, TTC30B, TWISTNB, UNC5H3, UNCX, utrophin, v-Myb, VAX2, VENTX2, Vmn2r30, WDR42B, WDR59, WFIKKN, Wnt-8a, X11α, XAGE-5, ZBTB42, ZBTB8, Zfhep, ZFHX2, Zfp663, Zic2, Zic3, ZNF205, ZNF206, ZNF347, ZNF439, ZNF585B, ZNF651, ZNF785, ZNF843, ZO-3, ZSWIM2, ZSWIM6, and ZUD_UNC5CL.Activator of:
β-glucosidase 2, 4933412E24Rik, achaete, ADAM15, ADAM23, ADAMTS-1, ADAMTS-10, ADAMTS-12, ADAMTS-13, ADAMTS-14, ADAMTS-16, ADAMTS-2, ADAMTS-3, ADAMTS-4, ADAMTS-8, ANKRD25, ANKRD29, APC5, APCDD1L, Aph-1c, ARX, atonal, BAF155, Barhl1, Barx2, Brn-2, C14orf135, C16orf71, C16orf91, C1orf114, C1orf95, C20orf160, C330019L16Rik, C6orf47_D17H6S53E, C7orf50, Cactin, cadherin-22, cadherin-26, CCDC46, CEACAM18, chordin, CIN85, Ciprofloxacin, CIR, CRELD1, CRIP3, CTLA-4, CUT, Cypt3, Delta, Delta-3, Delta-4, Deltex-4, DLK, EBV EBNA-3A, EG245190, ephrin-B1, EXDL3, EXOSC4, FAM100B, FAM113A, FAM116A, FAM116B, FAM124A, FAM131A, FAM150A, FAM198A, FAM65C, FAM82B, FAM83H, FAM86B2, FAM90A10, FAM90A12, FAM90A13, Fat, FGF-6, FGF-BP3, FJX1, FLYWCH2, FOXC1, FOXC2, FOXD4, FOXP4, GDF-11, GIPC, GLI-4, GRHL3, HepaCAM, HES2, HoxC4, HPV16 E4, HRT3, HS3ST2, Id1, Id4, IPCEF1, IRX4, Jagged, JAZF1, KIAA1024L_A730017C20Rik, KTELC1, LIN-31, LIN-41, LOC728591, LOC728867, LRRC1, LRRC15, LRRC37A, Lunatic Fringe, LYPD3, MAB21L2, MACS1, Mam1, MAML3, MEF-2C, MESP2, MIA2, MLLT11, MPZL1, musculin, Nek7, Neuron navigator 2, neuropilin, NgBR, Nkx-6.3, NPAS3, OCIAD2, OLFML2A, Olfr394, OR13C3, Pax-8, Pbx 4, PCDHA7, PCDHGB7_Pcdhgb7, PCNXL2, Pecanex 2, POFUT1, Prop-1, PRX1, Rab 5C, RASAL3, Raver2, RG9MTD3, RNF10, RUNDC1, RYK, SBF2, SCAI, SEMA3A, SEMA4B, SHISA3, Sox-10, Sox-7, SPATA32, SPPL3, SUSD2, TANC2, TBX15, Tcam1, THAP2, TMEM147, TSHZ1, TTC3, UHRF1BP1, Vancomycin, VSX1, VWC1, WDR54, WIF-1, XEDAR, ZCCHC12, and ZMYM3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DAPT, 5 mg | sc-201315 | 5 mg | $99.00 | |||
DAPT, 25 mg | sc-201315A | 25 mg | $335.00 | |||
DAPT, 100 mg | sc-201315B | 100 mg | $836.00 | |||
DAPT, 1 g | sc-201315C | 1 g | $2099.00 |