You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
DAPT is a potent and specific inhibitor of γ-secretase. It has been shown to cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ40 and Aβ42 respectively). There is evidence that DAPT does not effect APPα and APPβ levels. It mimics notch signaling deficiencies at morphological, molecular and biochemical levels and has been shown to block notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC).
1. Dovey, H F., et al., 2001. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. Journal of neurochemistry. 76(1): 173-81. PMID: 11145990
2. Geling, Andrea., et al., 2002. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO reports. 3(7): 688-94. PMID: 12101103
3. Lanz, Thomas A., et al., 2003. The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice. The Journal of pharmacology and experimental therapeutics. 305(3): 864-71. PMID: 12626636
4. Gowrishankar, Kavitha., et al., 2004. Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. Journal of cell science. 117(Pt 18): 4099-111. PMID: 15280425
5. De Smedt, Magda., et al., 2005. Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. Blood. 106(10): 3498-506. PMID: 16030192
6. El Mouedden, Mohammed., et al., 2006. Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. Current pharmaceutical design. 12(6): 671-6. PMID: 16472156
See how others have used DAPT. Click on the entry to view the PubMed entry .
PMID: # 30951821 Bruno, A. et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 1642-1650.
PMID: # 30839137 Niu, Y. et al. 2019. Cell Biol. Int.
PMID: # 29393429 Chen, DW. et al. 2018. Mol Med Rep. 17: 4965-4972.
PMID: # 29636838 Yu, L. et al. 2018. Oxid Med Cell Longev. 2018: 2750695.
PMID: # 29345284 Li, L. et al. 2018. Int. J. Oncol. 52: 473-484.
PMID: # 29286081 Liu, Z. et al. 2018. Int. J. Mol. Med. 41: 1560-1572.
PMID: # 28771710 Lee, ML. et al. 2017. J. Neurochem.
PMID: # 27901069 Mariscal, J. et al. 2016. Sci Rep. 6: 37820.
PMID: # 26523864 Zhao, E. et al. 2016. Nat. Immunol. 17: 95-103.
PMID: # 26648098 Gao, Y. et al. 2016. International journal of oncology. 48: 281-92.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.