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BAY 11-7082 (CAS 19542-67-7)

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Alternate Names:
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile; 3- [(4- methylphenyl)sulfonyl]- (2E)- propenenitrile
Application:
BAY 11-7082 is an anti-inflammatory agent and NFκB inhibitor
CAS Number:
19542-67-7
Purity:
≥98%
Molecular Weight:
207.25
Molecular Formula:
C10H9NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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BAY 11-7082 is a synthetic compound widely used in biological research due to its role as an inhibitor of NF-kappaB activation. NF-kappaB is a protein complex that controls the transcription of DNA, cytokine production, and cell survival. BAY 11-7082 exerts its effect by inhibiting the phosphorylation of I-kappaB alpha, an inhibitor of NF-kappaB, thereby preventing the translocation of NF-kappaB to the nucleus and its subsequent transcriptional activities. This inhibition is particularly useful in studies exploring the signal transduction pathways involved in inflammation, immune response, and cancer. Researchers employ BAY 11-7082 to dissect the cellular responses mediated by NF-kappaB and to understand how modulation of this pathway can affect various disease states. Moreover, the compound is used to investigate the role of NF-kappaB in the regulation of apoptosis, as blocking its activity can lead to increased apoptosis in certain cell types.


BAY 11-7082 (CAS 19542-67-7) References

  1. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis.  |  Thévenod, F., et al. 2000. J Biol Chem. 275: 1887-96. PMID: 10636889
  2. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.  |  Remacle-Bonnet, MM., et al. 2000. Cancer Res. 60: 2007-17. PMID: 10766192
  3. Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells.  |  Keller, SA., et al. 2000. Blood. 96: 2537-42. PMID: 11001908
  4. Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E.  |  Petegnief, V., et al. 2001. Neuroscience. 104: 223-34. PMID: 11311545
  5. Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death.  |  Kauppinen, TM. and Swanson, RA. 2005. J Immunol. 174: 2288-96. PMID: 15699164
  6. BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.  |  Irrera, N., et al. 2017. Clin Sci (Lond). 131: 487-498. PMID: 28096316
  7. In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri.  |  Debnath, A., et al. 2018. Front Microbiol. 9: 414. PMID: 29559968
  8. BAY-11-7082 induces apoptosis of multiple myeloma U266 cells through inhibiting NF-κB pathway.  |  Wang, Y., et al. 2018. Eur Rev Med Pharmacol Sci. 22: 2564-2571. PMID: 29771406
  9. P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk.  |  Li, Z., et al. 2021. Oxid Med Cell Longev. 2021: 8868361. PMID: 33532039
  10. Exploration of BAY 11-7082 as a Potential Antibiotic.  |  Coles, VE., et al. 2022. ACS Infect Dis. 8: 170-182. PMID: 34860493
  11. BAY 11-7082 inhibits the secretion of interleukin-6 by senescent human microglia.  |  Cook, M., et al. 2022. Biochem Biophys Res Commun. 617: 30-35. PMID: 35671608
  12. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.  |  Pierce, JW., et al. 1997. J Biol Chem. 272: 21096-103. PMID: 9261113

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BAY 11-7082, 5 mg

sc-200615B
5 mg
$61.00

BAY 11-7082, 10 mg

sc-200615
10 mg
$83.00

BAY 11-7082, 50 mg

sc-200615A
50 mg
$349.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. BAY 11-7082, sc-200615, is in white powder or crystalline form.
Answered by: Chemical Support 4
Date published: 2017-05-02

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, BAY 11-7082 (CAS 19542-67-7), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-30
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Rated 5 out of 5 by from Working wellWorking well. Purity is good.
Date published: 2015-04-03
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BAY 11-7082 is rated 5.0 out of 5 by 1.
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