SB 203580 CAS: 152121-47-6
MF: C21H16FN3OS
MW: 377.43

SB 203580 (CAS 152121-47-6)

SB 203580 | CAS 152121-47-6 is rated 5.0 out of 5 by 5.
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Alternate Names: SB 203580 is also known as RWJ 64809.
Application: SB 203580 is a pyridinyl imidazole and specific inhibitor that suppresses p38 mediated activation of MK2.
CAS Number: 152121-47-6
Purity: ≥98%
Molecular Weight: 377.43
Molecular Formula: C21H16FN3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SB 203580 is a pyridinyl imidazole which suppresses the p38 mediated activation of MAPKAP kinase-2 (MAPKAP K2 or MK2), yet does not disrupt JNK activity. Mitogen-activated protein kinases (MAPK) are a group of serine and threonine-specific kinases sensitive to cellular stress, heat shock and proinflammatory cytokines. p38 MAPK is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 inhibits the phosphorylation of heat shock protein 27 (HSP 27). SB 203580 has been shown to induce the activation of Raf-1. SB 203580 has also been shown to prevent the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1). SB 203580 is a useful tool to assess the physiological roles of p38, and for deriving and maintaining embryonic stem cells.


References

1. Cuenda, A., et al. 1995. FEBS Lett. 364: 229-233. PMID: 7750577

2. Saklatvala, J., et al. 1996. J. Biol. Chem. 271: 6586-6589. PMID: 8636072

3. Young, P.R., et al. 1997. J. Biol. Chem. 272: 12116-12121. PMID: 9115281

4. Clerk, A. and Sugden, P.H. 1998. FEBS Lett. 426: 93-96. PMID: 9598985

5. Hashimoto, S., et al. 1999. Biochem. Biophys. Res. Commun. 258: 443-447. PMID: 10329406

6. Kalmes, A., et al. 1999. FEBS Lett. 444: 71-74. PMID: 10037150

7. Hall-Jackson, C.A., et al. 1999. Oncogene. 18: 2047-2054. PMID: 10321729

8. Qi, X., et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 6027-6032. PMID: 15075392

9. Cao, W., et al. 2006. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G672-G680. PMID: 16645161

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), aqueous buffers (Sparingly soluble), methanol, acetone, ethanol (~0.2 mg/ml), and 1:9 solution of DMF:PBS(PH 7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
280.73° C (Predicted)
Boiling Point :
~615.6° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.71
IC50 :
p38 MAP kinase : IC50 = 34 nM; IL-1 and TNF-α : IC50 = 50-100 nM (LPS-stimulated human monocytes and the human monocyte cell line THP-1); SAPK2a/p38: EC5050 = 50 nM; SAPK2b/p38β2: IC50 = 500 nM
Ki Data :
MAP kinase p38 alpha: Ki= 18 nM (Homo sapiens); c-Jun N-terminal kinase 3: Ki= 90 nM (Homo sapiens)
pK Values :
pKb: 9.09
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UT3967600
PubChem CID :
MDL Number :
MFCD00922198
SMILES :
CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

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Certificate of Analysis

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SB 203580 (CAS 152121-47-6)  Product Citations

See how others have used SB 203580 (CAS 152121-47-6). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 259 total

PMID: # 33921748  Shi, Q.|Hu, B.|Yang, C.|Zhao, L.|Wu, J.|Qi, N.| et al. 2021. Int J Mol Sci. 22:

PMID: # 34246054  Zhang, M.|Liu, J.|Gao, R.|Hu, Y.|Lu, L.|Liu, C.|Ai, L.|Pan, J.|Tian, L.|Fan, J.| et al. 2021. Cytokine. 146: 155630.

PMID: # 33990641  Hirata, Y.|Takahashi, M.|Yamada, Y.|Matsui, R.|Inoue, A.|Ashida, R.|Noguchi, T.|Matsuzawa, A.| et al. 2021. Sci Rep. 11: 10350.

PMID: # 34070682  Mezzasoma, L.|Talesa, VN.|Costanzi, E.|Bellezza, I.| et al. 2021. Biomolecules. 11:

PMID: # 34165247  Ho, HY.|Chen, PJ.|Lo, YS.|Lin, CC.|Chuang, YC.|Hsieh, MJ.|Chen, MK.| et al. 2021. Environ Toxicol.

PMID: # 33578238  Ho, HY.|Lin, CC.|Chuang, YC.|Lo, YS.|Hsieh, MJ.|Chen, MK.| et al. 2021. Biomed Pharmacother. 137: 111362.

PMID: # 34065077  Bharath Kumar, V.|Lin, JT.|Mahalakshmi, B.|Chuang, YC.|Ho, HY.|Lin, CC.|Lo, YS.|Hsieh, MJ.|Chen, MK.| et al. 2021. Int J Mol Sci. 22:

PMID: # 33463904  Venter, C.|Myburgh, KH.|Niesler, CU.| et al. 2021. Physiol Rep. 9: e14704.

PMID: # 32999166  Hirata, Y.|Nada, Y.|Yamada, Y.|Toyama, T.|Fukunaga, K.|Hwang, GW.|Noguchi, T.|Matsuzawa, A.| et al. 2020. Biol Pharm Bull. 43: 1562-1569.

PMID: # 33101201  Kumar, VB.|Lin, SH.|Mahalakshmi, B.|Lo, YS.|Lin, CC.|Chuang, YC.|Hsieh, MJ.|Chen, MK.| et al. 2020. Front Endocrinol (Lausanne). 11: 568436.

Citations 1 to 10 of 259 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3533, is provided as a white powder. If you have any further the questions or concerns, please feel free to contact our Technical Services department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17

What is the long-term storage recommendation for this product in solution with DMSO?

Asked by: two2igm05
Thank you for your question. In DMSO, it can be stored for up to 6 months without degradation at -80 degrees Celsius. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-16
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Rated 5 out of 5 by from 挺好的 前几天刚买的,感觉还不错!实验结果和预想的一致,但我一直没搞明白,SB203580能否抑制p38MAPK的磷酸化?
Date published: 2020-08-22
Rated 5 out of 5 by from SB203580 I bough this copped to study its effects on ipsc. Im very happy with the compound performance.
Date published: 2018-03-19
Rated 5 out of 5 by from Good features! I bought it 28 months ago and boght it again 25 months ago. The inhibitive effect was very good and specific.
Date published: 2016-11-01
Rated 5 out of 5 by from The SCBT product The SCBT product, sc-3533, a p38MAPK inhibitor, was used to pre-treat HUVEC cells prior to exposure to TNF in an effort to see if TNF has an effect on genes involved in p38MAPK mediated down regulation (PubMed ID 24299952). -SCBT Publication Review
Date published: 2015-03-06
Rated 5 out of 5 by from H1299 and A549 cells were pre H1299 and A549 cells were pre-treated with sc-3533 (from SCBT) before exposure to LY2603618 to see if p38 MAPK plays a part in LY2603618 induced caspase cleavage (PubMed ID 24928205). -SCBT Publication Review
Date published: 2015-03-06
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