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Resveratrol (CAS 501-36-0)

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Alternate Names:
Trans-3,4′,5-Trihydroxystilbene; 1,3-Benzenediol, 5-[2-(4-hydroxyphenyl)ethenyl]-
Application:
Resveratrol is a natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1
CAS Number:
501-36-0
Purity:
≥98%
Molecular Weight:
228.24
Molecular Formula:
C14H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol derived from red wine in Asian folk-medicine Resveratrol and its glycoside,Polydatin (sc-203203) are the primary ingredients of Kojo-Kon (derived from the dried root of Japanese knotweed). Resveratrol, a trihydroxystilbene, is derived from various sources and has been studied with regard to numerous applications including reducing serum lipids, inhibition of platelet aggregation, and actions as a chemopreventative agent and antioxidant. Resveratrol may act to increase the longevity of yeast as well as having antiproliferative on cancer stem cells. Resveratrol is a specific inhibitor of Cox-1 (cyclooxygenase-1) via inhibition of the hydroperoxidase activity of Cox-1. Resveratrol has also been used extensively in stem cell studies to enhance self-renewal and multipotency of mesencymal stem cells (MSC′s). Numerous studies have been conducted with regard to Resveratrol-modified cardiac stem cells enhancing cardiac healing. Similar studies with bone marrow derived stem cells (BMSCs) have shown that Resveratrol acts as a NF-κB inhibitor to protect Msc-derived chondrocytes. Additional research with Resveratrol used to treat adipose-derived mesenchymal stem cells (ADMSCs) resulted in increased alkaline phosphatase activity and osteocalcin levels thus enriching the MSC and osteoprogenitor cell populations in cultured ADMSCs. Resveratrol is also known as Trans-3,4′,5-Trihydroxystilbene, and 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol.


Resveratrol (CAS 501-36-0) References

  1. Resveratrol is a selective human cytochrome P450 1A1 inhibitor.  |  Chun, YJ., et al. 1999. Biochem Biophys Res Commun. 262: 20-4. PMID: 10448061
  2. Biological effects of resveratrol.  |  Frémont, L. 2000. Life Sci. 66: 663-73. PMID: 10680575
  3. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.  |  Bowers, JL., et al. 2000. Endocrinology. 141: 3657-67. PMID: 11014220
  4. Pharmacological studies on resveratrol.  |  Kimura, Y. 2003. Methods Find Exp Clin Pharmacol. 25: 297-310. PMID: 12808475
  5. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.  |  Howitz, KT., et al. 2003. Nature. 425: 191-6. PMID: 12939617
  6. Therapeutic potential of resveratrol: the in vivo evidence.  |  Baur, JA. and Sinclair, DA. 2006. Nat Rev Drug Discov. 5: 493-506. PMID: 16732220
  7. Resveratrol protects bone marrow mesenchymal stem cell derived chondrocytes cultured on chitosan-gelatin scaffolds from the inhibitory effect of interleukin-1beta.  |  Lei, M., et al. 2008. Acta Pharmacol Sin. 29: 1350-6. PMID: 18954530
  8. Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells.  |  Kao, CL., et al. 2010. Stem Cells Dev. 19: 247-58. PMID: 19656070
  9. Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium.  |  Gurusamy, N., et al. 2010. J Cell Mol Med. 14: 2235-9. PMID: 20716127
  10. Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.  |  Pandey, PR., et al. 2011. Breast Cancer Res Treat. 130: 387-98. PMID: 21188630
  11. Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells.  |  Chanvitayapongs, S., et al. 1997. Neuroreport. 8: 1499-502. PMID: 9172162
  12. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.  |  Gehm, BD., et al. 1997. Proc Natl Acad Sci U S A. 94: 14138-43. PMID: 9391166
  13. Resveratrol, a remarkable inhibitor of ribonucleotide reductase.  |  Fontecave, M., et al. 1998. FEBS Lett. 421: 277-9. PMID: 9468322
  14. Identification of new genes differentially expressed in breast carcinoma cells treated with human chorionic gonadotropin.  |  Srivastava, P., et al. 1998. Int J Oncol. 13: 465-9. PMID: 9683780

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Resveratrol, 100 mg

sc-200808
100 mg
$80.00

Resveratrol, 500 mg

sc-200808A
500 mg
$220.00

Resveratrol, 5 g

sc-200808B
5 g
$460.00

Does the company guarantee the shipping of Resveratrol under - 20 degrees to Iraq?

Asked by: Aveen
Resveratrol is shipped on blue ice and the recommended storage is - 20 degrees .
Answered by: BlakeJ
Date published: 2025-09-12

how long resveratrol can be stored at -20°C?

Asked by: Jonatan A
Thank you for your question. We offer a warranty of one year on all purchased products. For a lot-specific expiry date please contact our technical service directly.
Answered by: Tech Support Europe
Date published: 2020-12-28

Hello. What is the recommended shipping temperature for Resveratrol? What would be the estimated shipping charges to Miami, Fl? If shipping temperature is at room temperature how long will it last?

Asked by: Renato Castanho
Thank you for your question. This chemical is shipped domestically and internationally at ambient temperature. Please contact our Customer Care Department to request a shipping quote.
Answered by: Technical Support
Date published: 2018-12-06

Hi, for this resveratrol is pure trans-resveratrol? My experiment need use trans-resveratrol and cis-resveratrol differently. Do this resveratrol contain cis-resveratrol? Thanks.

Asked by: Ronni
Thank you for your question. The product that we offer, Resveratrol: sc-200808, is the trans isomer of Resveratrol and does not contain the cis isomer.
Answered by: Technical Support
Date published: 2020-01-17

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Resveratrol, sc-200808, is in white to off-white to light yellow powder.
Answered by: Chemical Support 4
Date published: 2017-04-06

Is this product sterile filtered?

Asked by: SCM4
Thank you for your question. Resveratrol, sc-200808, is not sterile filtered, though we welcome end-users to do it themselves.
Answered by: TechService7
Date published: 2018-03-13

Is sc-200808 HPLC grade?

Asked by: two2igm05
Thank you for your question. Resveratrol, sc-200808, is HPLC grade.
Answered by: TechService7
Date published: 2016-12-28

Was method was used to purify this product?

Asked by: SCM4
Resveratrol (CAS 501-36-0) was purified by HPLC.
Answered by: Tech Service 2
Date published: 2016-12-23
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