Curcumin CAS: 458-37-7
MF: C21H20O6
MW: 368.38

Curcumin (CAS 458-37-7)

Curcumin | CAS 458-37-7 is rated 4.0 out of 5 by 1.
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Alternate Names: Curcumin is also known as Diferuloylmethane.
Application: Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP.
CAS Number: 458-37-7
Purity: ≥95%
Molecular Weight: 368.38
Molecular Formula: C21H20O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa. Curcumin is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.


References

1. Flynn, D.L. et al. 1986. Prostaglandins Leukot Med. 22(3): 357-360. PMID: 3460103

2. Flynn, D.L. et al. 1986. Prostaglandins Leukot Med. 24(2-3): 195-198. PMID: 3467378

3. Chan, M.M. 1995. Biochem. Pharmacol. 49(11): 1551-1556. PMID:

4. Kuo, M.L. et al. 1996. Biochim. Biophys. Acta. 1317(2): 95-100. PMID: 8950193

5. Singh, A.K. et al. 1996. Cancer Lett. 107(1): 109-115. PMID: 8913274

6. Jiang, M.C. et al. 1996. Nutr Cancer. 26(1): 111-120. PMID: 8844727

7. Sokoloski, J.A. et al. 1997. Oncol. Res. 9(1): 31-39. PMID: 9112258

8. Kumar, A. et al. 1998. Biochem. Pharmacol. 55(6): 775-783. PMID: 9586949

9. Chen, Y.R. and Tan, T.H. 1998. Oncogene. 17(2): 173-178. PMID: 9674701

Appearance :
Powder
Physical State :
Solid
Derived From :
Turmeric rhizome
Solubility :
Soluble in DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform. Insoluble in ethanol.
Storage :
Store at room temperature
Melting Point :
170-175° C
Boiling Point :
~591.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.42
IC50 :
5-lipoxygenase: IC50 = 8 µM; cyclooxygenase: IC50 = 52 µM; nitric oxide synthase in activated macrophages: IC50 = 6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MI5230000
PubChem CID :
969516
Merck Index :
14: 2673
MDL Number :
MFCD00008365
EC Number :
207-280-5
Beilstein Registry :
2306965
SMILES :
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

Download SDS (MSDS)

Certificate of Analysis

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Curcumin (CAS 458-37-7)  Product Citations

See how others have used Curcumin (CAS 458-37-7). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 31278615  2019. Cardiovasc. Toxicol.

PMID: # 29740418  Simpson, S. et al. 2018. Front Microbiol. 9: 788.

PMID: # 28958556  Grzesik, M. et al. 2018. Food Chem. 241: 480-492.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28115242  Jeong, CH.|Seok, JS.|Petriello, MC.|Han, SG.| et al. 2017. Toxicology. 379: 31-39.

PMID: # 25262359  Jiang, AJ. et al. 2015. Mol. Biol. Rep. 42: 267-75.

PMID: # 25823828  Zhang, X. et al. 2015. Molecular medicine reports. 12: 1347-55.

PMID: # 24418562  Narayanan, A. et al. 2014. Virology. 449: 270-86.

PMID: # 24007195  Xue, J. et al. 2013. Scand. J. Immunol. 78: 419-25.

PMID: # 22847000  Narayanan, A. et al. 2012. The Journal of biological chemistry. 287: 33198-214.

Citations 1 to 10 of 18 total

Can we dissolve curcumin in PBS (Phosphate buffered saline) for oral (gavage) administration to mice? If yes, please provide a reference. Thanks!

Asked by: Ayeisha
Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds.
Answered by: Technical Support
Date published: 2018-12-17

Would it be soluble in a buffer? In this case, my buffer would constitute of HEPES, KCl, Glycerol, DTT, BSA and Triton X-100.

Asked by: nabn
Thank you for your question. Curcumin is soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (&lt; 0.1 mg/ml), and chloroform.
Answered by: Technical Support
Date published: 2020-04-28

Curcumin dissolved in DMSO as stock solution (20 mg/mL). But once we dilute it in 1:100 in RPMI 1640 medium for measuring MIC of fungi, it formed precipitate at the well bottom of 96-well plate. Do we have any solution for this?

Asked by: Jasper
Thank you for your question. This product is not provided in a ready for cell culture format, and we recommend filtering before use to ensure that it is appropriate for cell culture applications. Please contact Technical Service by phone, (800)-457-3801 option 2, email &lt;[email protected]&gt;, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2017-07-17

What is the recommended storage temperature? How should this be stored when dissolved?

Asked by: chemicalsmg
Thank you for your question. The compound, sc-200509, should be stored at room temperature. Once dissolved, the solution should remain stable for approximately 3 months if stored at -20&ordm;C. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-26
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