Date published: 2025-10-15

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SB 431542 (CAS 301836-41-9)

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Alternate Names:
SB 431542 is also known as TGF-β RI Kinase Inhibitor VI.
Application:
SB 431542 is a Potent, selective inhibitor of TGF-βRI, specifically at ALK5 and its relatives ALK4 and ALK7.
CAS Number:
301836-41-9
Purity:
≥98%
Molecular Weight:
384.39
Molecular Formula:
C22H16N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGF-β (transforming growth factor-β) superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7. Renal carcinoma studies have demonstrated that SB 431542 is a selective inhibitor of Smad3 phosphorylation (IC50= 94nM) and TGF-β-1 collagen induced lα1 (col Iα1). It has been reported that SB 431542 does not affect the JNK, ERK, or p38 MAP kinase pathways. SB 431542 may act to suppress TGF-β induced growth stimulation in MG63 cells, inhibit the motility and proliferation of glioma cells, and block the phosphorylation and translocation of SMADs. SB 431542 is also known as 4-[4-(1,3-Benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide, TGF-β RI Kinase Inhibitor VI, and ALK inhibitor.


SB 431542 (CAS 301836-41-9) References

  1. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.  |  Laping, NJ., et al. 2002. Mol Pharmacol. 62: 58-64. PMID: 12065755
  2. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.  |  Inman, GJ., et al. 2002. Mol Pharmacol. 62: 65-74. PMID: 12065756
  3. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.  |  Matsuyama, S., et al. 2003. Cancer Res. 63: 7791-8. PMID: 14633705
  4. SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.  |  Hjelmeland, MD., et al. 2004. Mol Cancer Ther. 3: 737-45. PMID: 15210860
  5. SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts.  |  Hasegawa, T., et al. 2005. J Dermatol Sci. 39: 33-8. PMID: 15978417
  6. SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.  |  Waghabi, MC., et al. 2007. Antimicrob Agents Chemother. 51: 2905-10. PMID: 17526757
  7. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.  |  Xiao, YQ., et al. 2009. Invest Ophthalmol Vis Sci. 50: 1698-706. PMID: 19098325
  8. Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/activin/nodal signaling using SB-431542.  |  Mahmood, A., et al. 2010. J Bone Miner Res. 25: 1216-33. PMID: 20200949
  9. Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity.  |  Tanaka, H., et al. 2010. Oncol Rep. 24: 1637-43. PMID: 21042762
  10. Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane.  |  Kalxdorf, M., et al. 2021. Nat Methods. 18: 84-91. PMID: 33398190
  11. Sustained Delivery of SB-431542, a Type I Transforming Growth Factor Beta-1 Receptor Inhibitor, to Prevent Arthrofibrosis.  |  Lee, AJ., et al. 2021. Tissue Eng Part A. 27: 1411-1421. PMID: 33752445

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SB 431542, 1 mg

sc-204265
1 mg
$80.00

SB 431542, 10 mg

sc-204265A
10 mg
$212.00

SB 431542, 25 mg

sc-204265B
25 mg
$408.00