Id1 Inhibitors
Id1 inhibitors belong to a specialized class of compounds designed to selectively target the inhibitor of DNA binding 1 (Id1) protein, a member of the helix-loop-helix (HLH) family of transcriptional regulators. Id1 plays a pivotal role in regulating gene expression by modulating the activity of transcription factors involved in various cellular processes, including cell proliferation, differentiation, and survival. As a negative regulator of basic HLH transcription factors, Id1 lacks the DNA-binding domain and functions by forming nonfunctional heterodimers with other HLH proteins, inhibiting their transcriptional activity. Id1 inhibitors are meticulously designed molecules engineered to interact with Id1, aiming to disrupt its interactions with other HLH proteins or modulate its role in cellular processes governed by gene expression.
Chemically, Id1 inhibitors are crafted to selectively bind to specific regions or functional domains of the Id1 protein, interfering with its ability to form nonfunctional heterodimers with other HLH proteins. The molecular structure of these inhibitors is intricately designed to fit into the binding sites or active regions of Id1, aiming to obstruct its function without significantly impacting other cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU can inhibit DNA synthesis. By affecting rapidly dividing cells, it may down-regulate Id1 expression in certain cancer cells. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor. By affecting protein turnover, it might influence Id1 stability and expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might modulate Id1 expression in certain cells under specific conditions through its anti-inflammatory effects. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, all trans can modulate cell differentiation and might influence Id1 expression in specific cellular contexts. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, can modulate various signaling pathways and might down-regulate Id1 expression in certain cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a green tea component, can inhibit various signaling pathways and might down-regulate Id1 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, which can influence protein synthesis and might down-regulate Id1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an ERK pathway inhibitor. The ERK pathway can modulate Id1 expression, and its inhibition might down-regulate Id1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor. By modifying chromatin structure, it can potentially down-regulate Id1 expression. | ||||||