Date published: 2025-10-11

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Retinoic Acid, all trans (CAS 302-79-4)

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Alternate Names:
Vitamin A acid
Application:
Retinoic Acid, all trans is an oxidized carboxylic acid form of Vitamin A, and an activator of RAR and RXR and used in stem cells
CAS Number:
302-79-4
Purity:
≥98%
Molecular Weight:
300.40
Molecular Formula:
C20H28O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Retinoic Acid, all trans is the oxidized carboxylic acid form of retinol, known in the dietary context as Vitamin A. Retinal (sc-210778) is the aldehyde form of retinol required by the retina of the eye for light absorption and visual processing. Retinoic Acid, all trans and the other retinoids are involved in a broad range of biological regulations, mediating differentiation, proliferation, and apoptosis. Binding of Retinoic Acid, all trans to the nuclear receptors RAR (retinoic acid receptor) and the RXR (retinoid X receptor) initiate signals for transcription and development. The intimate relationship between retinoids and cell cycle regulation has been implicated in suppression of oncogenic proliferation. Also available in a photoactivatable, caged form (sc-202089).


Retinoic Acid, all trans (CAS 302-79-4) References

  1. The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells.  |  Boylan, JF. and Gudas, LJ. 1992. J Biol Chem. 267: 21486-91. PMID: 1328234
  2. Multiplicity generates diversity in the retinoic acid signalling pathways.  |  Leid, M., et al. 1992. Trends Biochem Sci. 17: 427-33. PMID: 1333659
  3. Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro.  |  Zouboulis, CC., et al. 1991. J Invest Dermatol. 96: 792-7. PMID: 1708801
  4. Retinoid pathway and cancer therapeutics.  |  Bushue, N. and Wan, YJ. 2010. Adv Drug Deliv Rev. 62: 1285-98. PMID: 20654663
  5. Photocarcinogenesis study of retinoic acid and retinyl palmitate [CAS Nos. 302-79-4 (All-trans-retinoic acid) and 79-81-2 (All-trans-retinyl palmitate)] in SKH-1 mice (Simulated Solar Light and Topical Application Study).  |  ,. 2012. Natl Toxicol Program Tech Rep Ser. 1-352. PMID: 23001333
  6. Simple in vitro migration assay for neural crest cells and the opposite effects of all-trans-retinoic acid on cephalic- and trunk-derived cells.  |  Usami, M., et al. 2014. Congenit Anom (Kyoto). 54: 184-8. PMID: 24708376
  7. Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells.  |  Maugeri, G., et al. 2016. Genes Cancer. 7: 47-58. PMID: 27014421
  8. All-trans retinoic acid induces mitochondria-mediated apoptosis of human adipose-derived stem cells and affects the balance of the adipogenic differentiation.  |  Schweich, LC., et al. 2017. Biomed Pharmacother. 96: 1267-1274. PMID: 29239820
  9. All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells.  |  Yao, W., et al. 2020. BMC Cancer. 20: 315. PMID: 32293355
  10. Administration of all-trans retinoic acid after experimental traumatic brain injury is brain protective.  |  Hummel, R., et al. 2020. Br J Pharmacol. 177: 5208-5223. PMID: 32964418
  11. Dynamic regulation of gene expression and morphogenesis in the zebrafish embryo test after exposure to all-trans retinoic acid.  |  Samrani, LMM., et al. 2023. Reprod Toxicol. 115: 8-16. PMID: 36375755
  12. Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.  |  Renaud, JP., et al. 1995. Nature. 378: 681-9. PMID: 7501014
  13. Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid.  |  Allenby, G., et al. 1994. J Biol Chem. 269: 16689-95. PMID: 8206989
  14. Antiproliferative activity of retinoic acid and some novel retinoid derivatives in breast and colorectal cancer cell lines of human origin.  |  Kaleagasioglu, F., et al. 1993. Arzneimittelforschung. 43: 487-90. PMID: 8494581
  15. Biochemical pathways of retinoid transport, metabolism, and signal transduction.  |  Napoli, JL. 1996. Clin Immunol Immunopathol. 80: S52-62. PMID: 8811064
  16. Quantitative high-performance liquid chromatographic determination of retinoids in human serum using on-line solid-phase extraction and column switching. Determination of 9-cis-retinoic acid, 13-cis-retinoic acid, all-trans-retinoic acid, 4-oxo-all-trans-retinoicacid and 4-oxo-13-cis-retinoic acid.  |  Gundersen, TE., et al. 1997. J Chromatogr B Biomed Sci Appl. 691: 43-58. PMID: 9140757

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Retinoic Acid, all trans, 500 mg

sc-200898
500 mg
$65.00

Retinoic Acid, all trans, 5 g

sc-200898A
5 g
$319.00

Retinoic Acid, all trans, 10 g

sc-200898B
10 g
$575.00

Retinoic Acid, all trans, 100 g

sc-200898C
100 g
$998.00

Hello, Can this product be used for neural differentiation of neuroblastoma cells? Thank you in advance.

Asked by: Neuro2amsc
Thank you for your question. Here is some literature that may be helpful: https://www.ncbi.nlm.nih.gov/pubmed/10027563 Feel free to reach out to technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-01-21

Can retinoic acid be used in a clinical trial for treatment of canine Cushing’s Syndrome?

Asked by: Parker12
Thank you for your question. Our products are of research grade quality and are intended for in vitro research use only. As such we could not provide support for such an experiment.
Answered by: Tech Support Europe
Date published: 2020-09-30
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Rated 5 out of 5 by from Britschgi et alBritschgi et al. (PubMed ID 20096012) used all-trans retinoic acid (ATRA) to treat acute promyeolocytic leukemia by causing the downregulation of 67LR.
Date published: 2015-05-22
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Retinoic Acid, all trans is rated 5.0 out of 5 by 1.
  • y_2025, m_10, d_9, h_7
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