Date published: 2025-10-17

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Fluorouracil (CAS 51-21-8)

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Alternate Names:
5-FU; 2,4-dioxo-5-fluoropyrimidine
Application:
Fluorouracil is a DNA synthesis blocker which arrests the cell cycle in G2
CAS Number:
51-21-8
Molecular Weight:
130.08
Molecular Formula:
C4H3FN2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fluorouracil is a potent antitumor agent that interferes with DNA synthesis via noncompetitive inhibition of thymidylate synthase (TS). The interruption of this enzyme blocks the synthesis of pyrimidine thymidine, a nucleotide required for DNA replication. Fluorouracil Induces apoptosis in human primary and metastatic colon adenocarcinoma cell lines in vitro. It has also been shown to arrest the cell cycle at the G2 phase. Fluorouracil acts as an antimetabolite to uracil. Research in mice has shown that fluorouracil administration may lead to potential degeneration of the CNS by damage to oligodendrocytes responsible for production of myelin sheaths.


Fluorouracil (CAS 51-21-8) References

  1. Sustained release of 5-fluorouracil from polymeric nanoparticles.  |  McCarron, PA., et al. 2000. J Pharm Pharmacol. 52: 1451-9. PMID: 11197072
  2. Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates.  |  Cai, TB., et al. 2003. Bioorg Med Chem. 11: 4971-5. PMID: 14604659
  3. Preparation and evaluation of N(3)-O-toluyl-fluorouracil-loaded liposomes.  |  Sun, W., et al. 2008. Int J Pharm. 353: 243-50. PMID: 18155370
  4. Selective bone targeting 5-fluorouracil prodrugs: synthesis and preliminary biological evaluation.  |  Ouyang, L., et al. 2011. Bioorg Med Chem. 19: 3750-6. PMID: 21612935
  5. Development of lattice-inserted 5-Fluorouracil-hydroxyapatite nanoparticles as a chemotherapeutic delivery system.  |  Tseng, CL., et al. 2015. J Biomater Appl. 30: 388-97. PMID: 26069284
  6. 5-Fluorouracil Chemotherapy for Dihydropyrimidine Dehydrogenase-deficient Patients: Potential of the Dose-escalation Method.  |  Yoshida, Y., et al. 2015. Anticancer Res. 35: 4881-7. PMID: 26254383
  7. Radiolabeling and in vitro evaluation of a new 5-fluorouracil derivative with cell culture studies.  |  Ilem-Ozdemir, D., et al. 2019. J Labelled Comp Radiopharm. 62: 874-884. PMID: 31495966
  8. Toxic Leukoencephalopathy: An unusual Presentation by 5-Fluorouracil Infusion.  |  Meena, VK., et al. 2020. Gulf J Oncolog. 1: 84-86. PMID: 32476656
  9. In vitro Scolicidal Efficacy of 5-Fluorouracil and Radiation Against Protoscoleces of Echinococcus granulosus Sensu Lato.  |  Lu, P., et al. 2022. Acta Parasitol. 67: 820-826. PMID: 35113338
  10. The reproductive effects of the cancer chemotherapy agent, Carmofur, on Daphnia magna are mediated by its metabolite, 5-Fluorouracil.  |  Gessner, EE., et al. 2022. Ecotoxicology. 31: 860-872. PMID: 35579761
  11. The first marine dual-drug cocrystal of cytarabine with 5-fluorouracil having synergistic antitumor effects shows superior biopharmaceutical peculiarities by oral administration.  |  Yu, YM., et al. 2022. Int J Pharm. 629: 122386. PMID: 36372139
  12. Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.  |  Pressacco, J., et al. 1995. Br J Cancer. 72: 939-42. PMID: 7547244
  13. Association of intratumoral pharmacokinetics of fluorouracil with clinical response.  |  Presant, CA., et al. 1994. Lancet. 343: 1184-7. PMID: 7909867
  14. Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia.  |  Shchepotin, IB., et al. 1994. Anticancer Res. 14: 1027-31. PMID: 8074445
  15. Enhanced induction of apoptosis of human gastric carcinoma cells after preoperative treatment with 5-fluorouracil.  |  Sugamura, K., et al. 1997. Cancer. 79: 12-7. PMID: 8988721

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fluorouracil, 1 g

sc-29060
1 g
$36.00

Fluorouracil, 5 g

sc-29060A
5 g
$149.00