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LY 294002 (CAS 154447-36-6)

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Alternate Names:
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Application:
LY 294002 is a potent blocker of PI 3-kinase/Akt signaling
CAS Number:
154447-36-6
Purity:
≥98%
Molecular Weight:
307.34
Molecular Formula:
C19H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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LY294002 is a potent inhibitor of PI 3-kinase, a protein in the phosphoinositide 3-kinase family of intercellular signal regulating enzymes. This compound is selective for PI 3-kinase p110 beta (PI 3-Kbeta) and PI 3-kinase p110 alpha (PI 3-Kalpha), although it will inhibit other PI 3 kinases at higher concentrations (IC50 = 310 nM and 730 nM for PI 3-Kbeta and PI 3-Kalpha, respectively). The pathway associated with these receptors is implicated in cancer and diabetes, and LY294002 is an important tool for studying this relationship. Reports indicate that LY294002 encourages apoptosis in such cells by blocking the PI 3-kinase/Akt signaling pathway which has been strongly related to cancer survival and proliferation. LY 294002 is an inhibitor of Pim-1, PI 3-kinase p110 delta and PI 3-kinase p110 gamma.


LY 294002 (CAS 154447-36-6) References

  1. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).  |  Hu, L., et al. 2000. Clin Cancer Res. 6: 880-6. PMID: 10741711
  2. Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.  |  Gagnon, A., et al. 2001. Endocrinology. 142: 205-12. PMID: 11145583
  3. The phosphoinositide 3-kinase pathway.  |  Cantley, LC. 2002. Science. 296: 1655-7. PMID: 12040186
  4. The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.  |  Semba, S., et al. 2002. Clin Cancer Res. 8: 1957-63. PMID: 12060641
  5. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.  |  Hori, Y., et al. 2002. Proc Natl Acad Sci U S A. 99: 16105-10. PMID: 12441403
  6. Exploring the specificity of the PI3K family inhibitor LY294002.  |  Gharbi, SI., et al. 2007. Biochem J. 404: 15-21. PMID: 17302559
  7. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.  |  Chaussade, C., et al. 2007. Biochem J. 404: 449-58. PMID: 17362206
  8. Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo.  |  Jiang, H., et al. 2010. J Exp Clin Cancer Res. 29: 34. PMID: 20412566
  9. Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression.  |  Bolen, CR., et al. 2014. Hepatology. 59: 1262-72. PMID: 23929627
  10. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence.  |  Sapey, E., et al. 2014. Blood. 123: 239-48. PMID: 24191150
  11. Rapamycin rescues ABT-737 efficacy in small cell lung cancer.  |  Gardner, EE., et al. 2014. Cancer Res. 74: 2846-56. PMID: 24614082
  12. ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo.  |  Malin, D., et al. 2015. Oncogene. 34: 5626-34. PMID: 25684139
  13. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.  |  Mbengue, A., et al. 2015. Nature. 520: 683-7. PMID: 25874676
  14. P110delta, a novel phosphoinositide 3-kinase in leukocytes.  |  Vanhaesebroeck, B., et al. 1997. Proc Natl Acad Sci U S A. 94: 4330-5. PMID: 9113989

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

LY 294002, 5 mg

sc-201426
5 mg
$121.00

LY 294002, 25 mg

sc-201426A
25 mg
$392.00

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, LY 294002 (CAS 154447-36-6), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-22
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Rated 5 out of 5 by from SelzmanSelzman, et. al. (PubMed ID 12234797 ) utilized LY 294002, a specific PI3 kinase antagonist, from Santa Cruz Biotechnology to determine the significance of PI3 Kinase signaling is to MCP-1-induced VSMC proliferation. After treatment, BrdU uptake was measured. -SCBT Publication Review
Date published: 2015-06-11
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LY 294002 is rated 5.0 out of 5 by 1.
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