Molecular structure of Withaferin A, CAS Number: 5119-48-2
Withaferin A (CAS 5119-48-2)
See product citations (20)
Alternate Names:
Withaferin A is also known as NSC 101088.
Application:
Withaferin A is a steroidal lactone and apoptosis inducer that induces aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts.
CAS Number:
5119-48-2
Purity:
≥95%
Molecular Weight:
470.59
Molecular Formula:
C28H38O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Withaferin A, a steroidal lactone that can be found in Withania somnifera, may act to have potent growth inhibitory activities. Withaferin A binds to Vimentin, the intermediate filament (IF) protein, and causes Vimentin filaments to aggregate in vitro. Additional experiments have reported Withaferin A to be a proteasome inhibitor, with a specific primary target for 20S proteasome 5 subunit. Withaferin A demonstrates the potential to inhibit NF B activation by prevention of tumor necrosis factor-activated I B kinase via a thioalkylation-sensitive redox mechanism. In other studies, Withaferin A was also observed to alter cytoskeletal architecture by covalently binding Annexin II and stimulating its basal F-actin cross-linking activity. Another characteristic of Withaferin A that has been noted is its ability to induce regeneration of axons and dendrites and also reconstruct pre and postsynapses in neurons.
Withaferin A (CAS 5119-48-2) References
- Neuritic regeneration and synaptic reconstruction induced by withanolide A. | Kuboyama, T., et al. 2005. Br J Pharmacol. 144: 961-71. PMID: 15711595
- Actin microfilament aggregation induced by withaferin A is mediated by annexin II. | Falsey, RR., et al. 2006. Nat Chem Biol. 2: 33-8. PMID: 16408090
- The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from 'Indian winter cherry'. | Yang, H., et al. 2007. Mol Pharmacol. 71: 426-37. PMID: 17093135
- Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. | Kaileh, M., et al. 2007. J Biol Chem. 282: 4253-4264. PMID: 17150968
- The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. | Bargagna-Mohan, P., et al. 2007. Chem Biol. 14: 623-34. PMID: 17584610
- Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. | Bargagna-Mohan, P., et al. 2010. J Biol Chem. 285: 7657-69. PMID: 20048155
- Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis. | Bargagna-Mohan, P., et al. 2013. PLoS One. 8: e63881. PMID: 23667686
- Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis. | Bargagna-Mohan, P., et al. 2015. PLoS One. 10: e0133399. PMID: 26186445
- The Use of Withaferin A to Study Intermediate Filaments. | Mohan, R. and Bargagna-Mohan, P. 2016. Methods Enzymol. 568: 187-218. PMID: 26795472
- Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis. | Tang, Q., et al. 2020. Cell Prolif. 53: e12706. PMID: 31642559
- Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives. | Behl, T., et al. 2020. Biomedicines. 8: PMID: 33291236
- Withaferin A mitigates metastatic traits in human oral squamous cell carcinoma caused by aberrant claudin-1 expression. | Shin, JA., et al. 2022. Cell Biol Toxicol. 38: 147-165. PMID: 33665778
- Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling. | Xu, K., et al. 2021. 3 Biotech. 11: 323. PMID: 34194907
- Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis. | Li, L., et al. 2022. Acta Biochim Pol. 69: 197-203. PMID: 35235278
- Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach. | Murugan, R., et al. 2022. Microb Pathog. 172: 105778. PMID: 36116607
Inhibitor of:
α-actinin-1, α4-crystallin, αC-crystallin, βA2-crystallin, βA3/A1-crystallin, βA4-crystallin, κB-Ras1, 14-3-3 σ, 20S Proteasome, 4732456N10Rik, 4732471D19Rik, 4922505E12Rik, 4930403N07Rik, 4930404N11Rik, 4930434E21Rik, 4930524E20Rik, 4931431F19Rik, 4932418E24Rik, 4932441B19Rik, 4933422H20Rik, 6330534C20Rik, ACTL8, ADAR2, Angiogenesis, ANKRD13A, ANKRD13B, AP1, APC10, APC11, Apollon, ARH, ARIH1, ARMCX1, Ataxin-3, Axotrophin, Bag-2, Bag-5, BIG1, C4orf30, C5orf25, CCDC158, Cdc23, Cdc37, Cdc37L1, CELF3, CGGBP1, COPZ, Coronin 2B, CPAMD8, CSN3, CSN7a, Cytokeratin 2E, Cytokeratin 4, Cytokeratin 6, Cytokeratin 75, Cytokeratin 8, Cytokeratin 9, Cytospin-A, D630042P16Rik, Dcun1D4, DEME-6, Derlin-2, Desmuslin, DKFZp667G2110, DNAAF3, DnaJB12, DnaJB3, DnaJC15, DnaJC16, DNAL1, DNALI1, Dyrk1A, E2F-2, EG639396, EG667977, Epiplakin (EPPK), FADD, FAT10, Fbxo12, Fbxo12J, FBXW10, Fbxw13, Fbxw16, FBXW17, Fbxw19, FBXW2, FKBP15, FKBP52, FLJ13236, FOXD4L2-6, FSIP2, GFAP, GGA2, Gm1568, Gm410, Gm514, Gm648, Gm906, GMCL1L, GOLGA8J, GPx-4, GrpEL1, H2-Abβ, H2-Dd, H2-Eκ, hCG_40738, Herc1, hnRNP H′/hnRNP H2, HPV16 E4, HRF, HSFX1, HSFY2, HSP 60, Hsp104, HSPA12A, HSPA2, HSPA4L, HSPA6, HSPB7, HSPBAP1, HspBP1, HSPC117, HSPC196, IκB-ζ, I830012O16Rik, IBRDC2, IER3IP1, ITPase, Josephin-3, KBTBD11, KBTBD4, KCMF1, Keratin 24, Keratin 39, Keratin 83, Kinectin 1, KLHDC1, KLHDC10, KLHDC6, KLHDC7A, KLHL11, KLHL35, KRTAP10-1, KRTAP10-7, KRTAP4-2, KRTAP5-4, KRTAP9-3, KRTAP9-L2, KV4.1, L7RN6, LA-PF4, Lce1m, LCE3A, LONRF2, LPPR3, LRSAM1, MAGE-B17, MAGE-B6, MARCH (membrane associated ring-CH-type finger), MetAP-1, MFSD11, Midline-1, Mill1, Mill2, MTERFD3, MuRF2, myopalladin, Myosin-XIX, NEDL1, NF-E2 p18, NF-H, NFκB p52, NFκB p65, NOL7, OBSL1, Olfr417, ORP150, OTUD6B, p105, P23, PARC, PC-PLD3, PDCL2, PDILT, Pellino 3, Pin1l, PKD1, PNAd, POT1, PPWD1, PRC1, Prdx6-rs2, prefoldin 1, prefoldin 2, prefoldin 5, prefoldin 6, PSMB11, PSMD11, PSME proteasome activator subunits (PA28), Psmg2, PTGES3L-AARSD1, PWP1, PYPAF7, RBM28, RBMY1A1, RFX1, RNF103, RNF121, RNF145, RNF152, RNF219, RNF222, RNF44, RNF5, Rpn2, RT1-Bβ, SAMD9, SCP-1, SEL-10, Selenoprotein K, SEMA4B, SerpinA3a, SerpinA3b, SerpinA3c, Serpinb3a, Serpinb3b, SGTA, SIAH-1B, SIMC1, Skn-1i, Slac2-a, SOCS-2, SODD (BAG cochaperone 4), Sox-2, SPECC1, spectrin β II, Staf-50, SUGT1, SUN3, SUSP4, Syncoilin, T6BP, TARDBP, TCP-1 η, TCP-1 θ, TCP-1 ζ, TCP-1 ζ2, THP, TIP120B, TLR5, TNF-R2, Torsin2A, TRADD, TRAF1, TRAF5, TRAF7, Trim12c, TRIM16, Trim29, TRIM31, TRIM37, TRIM40, TRIM41, TRIM45, TRIM47, TRIM6-TRIM34, TRIM64B, TRIM79, TTC24, UBAP2, UBE1L, UBE4A, UBL4B, UBL5, UBQLN3, Ubr1, Ubr2, Ubr3, Ubr7, UFD1, UFSP2, UIP5, USP41, V-ATPase D2, V1RF2, V1RF3, V1RG6, Vimentin, vinculin, VWA3B, VWA9, WAVE1, Xlr3c, Xlr4c, Xlr5c, ZFAND1, ZNF225, ZNF233, ZNF552, ZNF555, ZNF727, and ZPBP2.Activator of:
β1 Tubulin, β4Q Tubulin, β8 Tubulin, 20S Proteasome α1, 20S Proteasome α5, 20S Proteasome β1, 20S Proteasome β2, 26S Proteasome, 4930444G20Rik, 4933402E13Rik, 4933422H20Rik, A730069N07Rik, ASB-11, ASB-12, B7-2, Bet1L, CD30, CD40L, CHIP, CRB3, D630042P16Rik, DnaJA4, DnaJB5, DnaJC11, DR5, E6-AP, EG623459, ENX-1, eRF3a, FAF1, FAM105B, FBXO11, Fbxo12J, FBXO3, FKBP52, FKBPL, Fn14, Fv1, Gm514, GP78-1, GRP 75, H2-Aa, HIV-1 Vif, HLTF, HSF1, HSF2, HSF3, HSP 27, HSP 40, HSP 40-4, HSP 47, HSP 90, HSP 90α, HSPA12B, HSPA4L, HSPB2, HSPC121, Id1, IRAK-M, KBTBD5, KLHDC8A, KLHL23, KLHL24, KLHL4, Klp3, LMP7, MECL-1, MTUS2, Ndfip1, NEDD4-L, Npl4, Nrdp1, NUDT21, p100, PCNP, Pdcd-4, PIASy, PLIC-2, PPIL2, PPIL4, prefoldin 3, PROS-30, Proteassemblin, PSMB4, PSMB6, PSMC1, PSMC4, PSMD1, PSMD5, PSMD7, PSR, reaper, RelB, RNF148, RNF165, RNF175, RNF180, RNF183, RNF214, RNF4, SENP5, SIAH3, Smurf2, Sp110, SUMO-4, Tau, TCP-1 η, TIP30, TNFα-IP 8L3, Tollip, TRAF4, TRIM35, TRIM58, TRIM6, TRIM69, TTLL12, UBA2, UBC8, UBE1L2, UBE2B, UBE2D3, UBE2L3, UBE2N, UBE2O, UBL3, UBXN2B, UNCL, USP11, USP14, USP2, USP45, USP5, USP9X, USPL1, WDR21A, WSB2, ZBTB6, and ZNF216.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Withaferin A, 1 mg | sc-200381 | 1 mg | $130.00 | |||
Withaferin A, 10 mg | sc-200381A | 10 mg | $583.00 | |||
Withaferin A, 100 mg | sc-200381B | 100 mg | $4172.00 | |||
Withaferin A, 1 g | sc-200381C | 1 g | $20506.00 |