Date published: 2026-5-17

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POLR Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of POLR Antibodies for investigating RNA polymerases in transcription regulation. POLR monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). RNA polymerases are essential enzymes responsible for synthesizing RNA from a DNA template, playing a critical role in gene expression and regulation. The POLR family, which includes RNA polymerase I, II, and III, is vital for the transcription of different classes of genes, influencing cellular processes such as growth, differentiation, and response to environmental signals. Understanding POLR protein function is crucial for elucidating mechanisms underlying various diseases, including cancer and genetic disorders. Researchers worldwide rely on POLR monoclonal antibodies to advance their studies in transcriptional regulation. POLR monoclonal antibodies enable detailed investigation of RNA polymerase localization, interactions, and activity patterns. The exceptional quality and reliability of Santa Cruz Biotechnology POLR monoclonal antibodies support researchers in making meaningful contributions to transcription biology and disease research.

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POLR Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

POLR1E Antibody (C-11)

sc-398270mouse IgG2a κ8-113 (h)WB, IP, IF, ELISAm, r, h
2
(1)

POLR2B Antibody (E-12)

sc-166803mouse IgG2a κ184-384 (h)WB, IP, IF, ELISAm, r, h
9
(2)

POLR2E Antibody (B-5)

sc-390979mouse IgG2a κFL (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(2)

POLR2E Antibody (C-10)

sc-390902mouse IgG1 κ7-210 (h)WB, IP, IF, ELISAm, r, h

new

(1)

POLR2G Antibody (C-2)

sc-398213mouse IgG1 κFL (h)WB, IP, IF, ELISAm, r, h
4
(2)

POLR2G Antibody (2781C2a)

sc-81112mouse IgG1Internal (h)WB, IPm, r, h

new

(1)

POLR2G Antibody (G-9)

sc-393890mouse IgG2a κFL (h)WB, IP, IF, ELISAm, r, h

new

(2)

POLR2I Antibody (F-11)

sc-398049mouse IgG1 κ1-120 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(1)

POLR2J1/2/3 Antibody (G-2)

sc-514129mouse IgG1 κ41-117 (h)WB, IP, IF, ELISAm, r, h
1
(1)

POLR3B Antibody (G-6)

sc-515362mouse IgG1 κ92-111 (h)WB, IP, IF, ELISAm, r, h
3
(1)

POLR3E Antibody (B-11)

sc-365703mouse IgG1 κ53-81 (h)WB, IP, IF, ELISAm, r, h
2
(1)

POLR CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

POLR1E CRISPR/Cas9 KO Plasmid (h)

sc-407602hGene KnockoutGFP0
(0)

POLR1E HDR Plasmid (h)

sc-407602-HDRhHomology Directed RepairPuromycin0
(0)

POLR3A CRISPR/Cas9 KO Plasmid (h)

sc-406851hGene KnockoutGFP0
(0)

POLR3A HDR Plasmid (h)

sc-406851-HDRhHomology Directed RepairPuromycin0
(0)

POLR3B CRISPR/Cas9 KO Plasmid (h)

sc-406739hGene KnockoutGFP0
(0)

POLR2J2 CRISPR/Cas9 KO Plasmid (h)

sc-416530hGene KnockoutGFP0
(0)

POLR2J2 HDR Plasmid (h)

sc-416530-HDRhHomology Directed RepairPuromycin0
(0)

POLR CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

POLR1E CRISPR Activation Plasmid (h)

sc-407602-ACThGene ActivationPuro, Blast, Hygro0
(0)

RPB2 CRISPR Activation Plasmid (h)

sc-402591-ACThGene ActivationPuro, Blast, Hygro0
(0)

POLR3GL CRISPR Activation Plasmid (h)

sc-413599-ACThGene ActivationPuro, Blast, Hygro0
(0)

POLR3GL CRISPR Activation Plasmid (h2)

sc-413599-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

POLR3GL Lentiviral Activation Particles (h)

sc-413599-LAChGene ActivationPuro, Blast, Hygro0
(0)

POLR3GL Lentiviral Activation Particles (h2)

sc-413599-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

POLR2J1 CRISPR Activation Plasmid (h)

sc-409187-ACThGene ActivationPuro, Blast, Hygro0
(0)

POLR siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

POLR1E siRNA (h)

sc-92929hGene SilencingN/A0
(0)

POLR1E shRNA Plasmid (h)

sc-92929-SHhGene SilencingPuromycin0
(0)

POLR1E shRNA (h) Lentiviral Particles

sc-92929-VhGene SilencingPuromycin0
(0)

POLR1E siRNA (m)

sc-152370mGene SilencingN/A0
(0)

POLR1E shRNA Plasmid (m)

sc-152370-SHmGene SilencingPuromycin0
(0)

POLR1E shRNA (m) Lentiviral Particles

sc-152370-VmGene SilencingPuromycin0
(0)

POLR2B siRNA (h)

sc-62962hGene SilencingN/A0
(0)

POLR2B shRNA Plasmid (h)

sc-62962-SHhGene SilencingPuromycin0
(0)

POLR2B shRNA (h) Lentiviral Particles

sc-62962-VhGene SilencingPuromycin0
(0)

POLR2B siRNA (m)

sc-62963mGene SilencingN/A0
(0)

POLR2B shRNA Plasmid (m)

sc-62963-SHmGene SilencingPuromycin0
(0)

POLR2B shRNA (m) Lentiviral Particles

sc-62963-VmGene SilencingPuromycin0
(0)

POLR2C siRNA (h)

sc-93093hGene SilencingN/A0
(0)

POLR2C shRNA Plasmid (h)

sc-93093-SHhGene SilencingPuromycin0
(0)

POLR2C shRNA (h) Lentiviral Particles

sc-93093-VhGene SilencingPuromycin0
(0)

POLR2C siRNA (m)

sc-106428mGene SilencingN/A0
(0)

POLR2C shRNA Plasmid (m)

sc-106428-SHmGene SilencingPuromycin0
(0)

POLR2C shRNA (m) Lentiviral Particles

sc-106428-VmGene SilencingPuromycin0
(0)

POLR2D siRNA (h)

sc-94864hGene SilencingN/A0
(0)

POLR2D shRNA Plasmid (h)

sc-94864-SHhGene SilencingPuromycin0
(0)

POLR2D shRNA (h) Lentiviral Particles

sc-94864-VhGene SilencingPuromycin0
(0)

POLR2D siRNA (m)

sc-152371mGene SilencingN/A0
(0)

POLR2D shRNA Plasmid (m)

sc-152371-SHmGene SilencingPuromycin0
(0)

POLR2D shRNA (m) Lentiviral Particles

sc-152371-VmGene SilencingPuromycin0
(0)

POLR2E siRNA (h)

sc-97922hGene SilencingN/A0
(0)

POLR2E shRNA Plasmid (h)

sc-97922-SHhGene SilencingPuromycin0
(0)

POLR2E shRNA (h) Lentiviral Particles

sc-97922-VhGene SilencingPuromycin0
(0)

POLR2E siRNA (m)

sc-152372mGene SilencingN/A0
(0)

POLR2E shRNA Plasmid (m)

sc-152372-SHmGene SilencingPuromycin0
(0)

POLR2E shRNA (m) Lentiviral Particles

sc-152372-VmGene SilencingPuromycin0
(0)

POLR2G siRNA (h)

sc-96905hGene SilencingN/A0
(0)

POLR2G shRNA Plasmid (h)

sc-96905-SHhGene SilencingPuromycin0
(0)

POLR2G shRNA (h) Lentiviral Particles

sc-96905-VhGene SilencingPuromycin0
(0)

POLR2G siRNA (m)

sc-77405mGene SilencingN/A0
(0)

POLR2G shRNA Plasmid (m)

sc-77405-SHmGene SilencingPuromycin0
(0)

POLR2G shRNA (m) Lentiviral Particles

sc-77405-VmGene SilencingPuromycin0
(0)

POLR2I siRNA (h)

sc-97881hGene SilencingN/A0
(0)

POLR2I shRNA Plasmid (h)

sc-97881-SHhGene SilencingPuromycin0
(0)

POLR2I shRNA (h) Lentiviral Particles

sc-97881-VhGene SilencingPuromycin0
(0)

Polr2j siRNA (m)

sc-152374mGene SilencingN/A0
(0)

Polr2j shRNA Plasmid (m)

sc-152374-SHmGene SilencingPuromycin0
(0)

Polr2j shRNA (m) Lentiviral Particles

sc-152374-VmGene SilencingPuromycin0
(0)

POLR2K siRNA (h)

sc-62836hGene SilencingN/A0
(0)

POLR2K shRNA Plasmid (h)

sc-62836-SHhGene SilencingPuromycin0
(0)

POLR2K shRNA (h) Lentiviral Particles

sc-62836-VhGene SilencingPuromycin0
(0)

POLR2K siRNA (m)

sc-62837mGene SilencingN/A0
(0)

POLR2K shRNA Plasmid (m)

sc-62837-SHmGene SilencingPuromycin0
(0)

POLR2K shRNA (m) Lentiviral Particles

sc-62837-VmGene SilencingPuromycin0
(0)

POLR2L siRNA (h)

sc-96685hGene SilencingN/A0
(0)

POLR2L shRNA Plasmid (h)

sc-96685-SHhGene SilencingPuromycin0
(0)

POLR2L shRNA (h) Lentiviral Particles

sc-96685-VhGene SilencingPuromycin0
(0)

POLR3A siRNA (h)

sc-90684hGene SilencingN/A
1
(0)

POLR3A shRNA Plasmid (h)

sc-90684-SHhGene SilencingPuromycin
1
(0)

POLR3A shRNA (h) Lentiviral Particles

sc-90684-VhGene SilencingPuromycin
1
(0)

POLR3A siRNA (m)

sc-152376mGene SilencingN/A0
(0)

POLR3A shRNA Plasmid (m)

sc-152376-SHmGene SilencingPuromycin0
(0)

POLR3A shRNA (m) Lentiviral Particles

sc-152376-VmGene SilencingPuromycin0
(0)

POLR3B siRNA (h)

sc-95786hGene SilencingN/A0
(0)

POLR3B shRNA Plasmid (h)

sc-95786-SHhGene SilencingPuromycin0
(0)

POLR3B shRNA (h) Lentiviral Particles

sc-95786-VhGene SilencingPuromycin0
(0)

POLR3B siRNA (m)

sc-152377mGene SilencingN/A0
(0)

POLR3B shRNA Plasmid (m)

sc-152377-SHmGene SilencingPuromycin0
(0)

POLR3B shRNA (m) Lentiviral Particles

sc-152377-VmGene SilencingPuromycin0
(0)

POLR3D siRNA (h)

sc-77815hGene SilencingN/A0
(0)

POLR3D shRNA Plasmid (h)

sc-77815-SHhGene SilencingPuromycin0
(0)

POLR3D shRNA (h) Lentiviral Particles

sc-77815-VhGene SilencingPuromycin0
(0)

POLR3D siRNA (m)

sc-152378mGene SilencingN/A0
(0)

POLR3D shRNA Plasmid (m)

sc-152378-SHmGene SilencingPuromycin0
(0)

POLR3D shRNA (m) Lentiviral Particles

sc-152378-VmGene SilencingPuromycin0
(0)

POLR3E siRNA (h)

sc-93337hGene SilencingN/A0
(0)

POLR3E shRNA Plasmid (h)

sc-93337-SHhGene SilencingPuromycin0
(0)

POLR3E shRNA (h) Lentiviral Particles

sc-93337-VhGene SilencingPuromycin0
(0)

POLR3E siRNA (m)

sc-152379mGene SilencingN/A0
(0)

POLR3E shRNA Plasmid (m)

sc-152379-SHmGene SilencingPuromycin0
(0)

POLR3E shRNA (m) Lentiviral Particles

sc-152379-VmGene SilencingPuromycin0
(0)

POLR3GL siRNA (h)

sc-78946hGene SilencingN/A0
(0)

POLR3GL shRNA Plasmid (h)

sc-78946-SHhGene SilencingPuromycin0
(0)

POLR3GL shRNA (h) Lentiviral Particles

sc-78946-VhGene SilencingPuromycin0
(0)

POLR3GL siRNA (m)

sc-152380mGene SilencingN/A0
(0)

POLR3GL shRNA Plasmid (m)

sc-152380-SHmGene SilencingPuromycin0
(0)

POLR3GL shRNA (m) Lentiviral Particles

sc-152380-VmGene SilencingPuromycin0
(0)

POLR3H siRNA (h)

sc-76194hGene SilencingN/A0
(0)

POLR3H shRNA Plasmid (h)

sc-76194-SHhGene SilencingPuromycin0
(0)

POLR3H shRNA (h) Lentiviral Particles

sc-76194-VhGene SilencingPuromycin0
(0)

POLR3H siRNA (m)

sc-152381mGene SilencingN/A0
(0)

POLR3H shRNA Plasmid (m)

sc-152381-SHmGene SilencingPuromycin0
(0)

POLR3H shRNA (m) Lentiviral Particles

sc-152381-VmGene SilencingPuromycin0
(0)

POLR3K siRNA (h)

sc-93095hGene SilencingN/A0
(0)

POLR3K shRNA Plasmid (h)

sc-93095-SHhGene SilencingPuromycin0
(0)

POLR3K shRNA (h) Lentiviral Particles

sc-93095-VhGene SilencingPuromycin0
(0)

POLR3K siRNA (m)

sc-152382mGene SilencingN/A0
(0)

POLR3K shRNA Plasmid (m)

sc-152382-SHmGene SilencingPuromycin0
(0)

POLR3K shRNA (m) Lentiviral Particles

sc-152382-VmGene SilencingPuromycin0
(0)

POLR2J1 siRNA (h)

sc-89724hGene SilencingN/A0
(0)

POLR2J1 shRNA Plasmid (h)

sc-89724-SHhGene SilencingPuromycin0
(0)

POLR2J1 shRNA (h) Lentiviral Particles

sc-89724-VhGene SilencingPuromycin0
(0)