Date published: 2026-5-2

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POLR Inhibitors

Santa Cruz Biotechnology now offers a broad range of POLR inhibitors for use in various applications. POLR inhibitors are chemicals that specifically target and inhibit the function of RNA polymerases, which are crucial enzymes responsible for transcribing DNA into RNA. These inhibitors are invaluable tools in molecular biology and genetics research, as they allow scientists to study the transcription process in detail by selectively blocking the activity of RNA polymerase. By understanding how RNA polymerases work and how they are regulated, researchers can gain insights into fundamental biological processes, such as gene expression, cell cycle control, and differentiation. POLR inhibitors are also used to explore the mechanisms of transcriptional regulation, investigate the role of RNA polymerases in various cellular pathways, and identify potential targets for further scientific exploration. The ability to manipulate transcriptional activity using POLR inhibitors has opened new avenues in the study of gene function, epigenetics, and the complex interplay between DNA, RNA, and proteins. These inhibitors serve as critical reagents in experiments designed to study the molecular underpinnings of cellular processes, contributing significantly to the advancement of basic and applied sciences. View detailed information on our available POLR inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Doxorubicin hydrochloride

25316-40-9sc-200923
sc-200923B
sc-200923A
sc-200923C
sc-200923D
5 mg
10 mg
25 mg
100 mg
250 mg
$87.00
$153.00
$214.00
$296.00
$530.00
31
(2)

Doxorubicin hydrochloride is a complex anthracycline compound characterized by its intercalation into DNA, which disrupts the replication process. This interaction stabilizes the topoisomerase II-DNA complex, leading to the formation of DNA breaks. Its unique planar structure allows for effective π-π stacking with nucleobases, enhancing its binding affinity. Additionally, the compound exhibits notable fluorescence properties, which can be leveraged for analytical applications in biochemical studies.