Date published: 2025-11-21

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ORC Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of ORC Antibodies for studying origin recognition complex proteins. ORC Antibodies are compatible with multiple research techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). The origin recognition complex (ORC) plays a fundamental role in initiating DNA replication by binding to replication origins and recruiting additional factors necessary for pre-replicative complex formation. Understanding ORC protein function is essential for uncovering the mechanisms of cell cycle regulation and genomic stability. Origin recognition complex components have been linked to various diseases, including cancer, highlighting their importance as research targets. Researchers can investigate DNA replication mechanisms using specific antibodies targeting different ORC subunits. Advanced detection methods, including horseradish peroxidase (HRP), phycoerythrin (PE), and fluorescein isothiocyanate (FITC) conjugates, enable precise visualization of ORC proteins. ORC Antibodies from Santa Cruz Biotechnology support researchers worldwide in advancing our understanding of DNA replication and its role in human health.

SEE ALSO...

ORC Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

ORC1 Antibody (7A7)

sc-23887rat IgG1(h)WB, IPm, r, h
7
(5)

ORC1 Antibody (F-10)

sc-398734mouse IgG1 κ782-861 (h)WB, IP, IF, ELISAh
3
(1)

ORC1 Antibody (3C166)

sc-71751mouse IgG1 κ(h)WB, IPh

new

(1)

ORC1 Antibody (3H2792)

sc-71752mouse IgG1 κ(h)WB, IPh

new

(1)

ORC1 Antibody (7F6/1)

sc-53390mouse IgG1 κ(h)WB, IPh

new

(1)

ORC2 Antibody (3G6)

sc-32734rat IgG2a557-574 (h)WB, IPh
20
(6)

ORC3 Antibody (1D6)

sc-23888rat IgG2b(h)WB, IP, IF, IHC(P)h
10
(3)

ORC3 Antibody (C-12)

sc-374231mouse IgG1 κ617-707 (h)WB, IP, IF, ELISAm, r, h

new

(2)

ORC4 Antibody (D-8)

sc-393985mouse IgM κ375-398 (h)WB, IP, IF, ELISAm, r, h

new

(1)

ORC4 Antibody (H-2)

sc-398455mouse IgG1 κ332-347 (h)WB, IP, IF, ELISAm, r, h

new

(1)

ORC6 Antibody (3A4)

sc-32735rat IgG2a7-23 (h)WB, IP, IF, IHC(P)m, r, h
10
(6)

ORC6 Antibody (D-4)

sc-390490mouse IgG1 κFL (h)WB, IP, IF, ELISAm, r, h
2
(2)

Non-Mammalian ORC Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

ORC1 Antibody (TK 1/2)

sc-53391mouse IgG2a κFL (Xenopus)WB, IP, ELISAx
2
(1)

Orc2 Antibody (C-5)

sc-398410mouse IgG2a κ611-622 (Saccharomyces cerevisiae)WB, IP, IF, ELISAy
1
(1)

Orc2 Antibody (SB46)

sc-56738mouse IgG1FL (S. cerevisiae)WB, IP, ELISASaccharomyces cerevisiae

new

(1)

ORC CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

ORC1 CRISPR/Cas9 KO Plasmid (h)

sc-418358hGene KnockoutGFP0
(0)

ORC1 HDR Plasmid (h)

sc-418358-HDRhHomology Directed RepairPuromycin0
(0)

ORC1 Double Nickase Plasmid (h)

sc-418358-NIChGene KnockoutPuromycin0
(0)

ORC1 Double Nickase Plasmid (h2)

sc-418358-NIC-2hGene KnockoutPuromycin0
(0)

ORC2 CRISPR/Cas9 KO Plasmid (h)

sc-402746hGene KnockoutGFP0
(0)

ORC2 HDR Plasmid (h)

sc-402746-HDRhHomology Directed RepairPuromycin0
(0)

ORC2 Double Nickase Plasmid (h)

sc-402746-NIChGene KnockoutPuromycin0
(0)

ORC2 Double Nickase Plasmid (h2)

sc-402746-NIC-2hGene KnockoutPuromycin0
(0)

ORC3 CRISPR/Cas9 KO Plasmid (h)

sc-405473hGene KnockoutGFP0
(0)

ORC3 HDR Plasmid (h)

sc-405473-HDRhHomology Directed RepairPuromycin0
(0)

ORC3 Double Nickase Plasmid (h)

sc-405473-NIChGene KnockoutPuromycin0
(0)

ORC3 Double Nickase Plasmid (h2)

sc-405473-NIC-2hGene KnockoutPuromycin0
(0)

ORC4 CRISPR/Cas9 KO Plasmid (h)

sc-403634hGene KnockoutGFP0
(0)

ORC4 HDR Plasmid (h)

sc-403634-HDRhHomology Directed RepairPuromycin0
(0)

ORC4 Double Nickase Plasmid (h)

sc-403634-NIChGene KnockoutPuromycin0
(0)

ORC4 Double Nickase Plasmid (h2)

sc-403634-NIC-2hGene KnockoutPuromycin0
(0)

ORC5 CRISPR/Cas9 KO Plasmid (h)

sc-409147hGene KnockoutGFP0
(0)

ORC5 HDR Plasmid (h)

sc-409147-HDRhHomology Directed RepairPuromycin0
(0)

ORC5 Double Nickase Plasmid (h)

sc-409147-NIChGene KnockoutPuromycin0
(0)

ORC5 Double Nickase Plasmid (h2)

sc-409147-NIC-2hGene KnockoutPuromycin0
(0)

ORC6 CRISPR/Cas9 KO Plasmid (h2)

sc-405854-KO-2hGene KnockoutGFP0
(0)

ORC6 HDR Plasmid (h2)

sc-405854-HDR-2hHomology Directed RepairPuromycin0
(0)

ORC6 Double Nickase Plasmid (h)

sc-405854-NIChGene KnockoutPuromycin0
(0)

ORC6 Double Nickase Plasmid (h2)

sc-405854-NIC-2hGene KnockoutPuromycin0
(0)

ORC CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

ORC1 CRISPR Activation Plasmid (h)

sc-418358-ACThGene ActivationPuro, Blast, Hygro0
(0)

ORC1 CRISPR Activation Plasmid (h2)

sc-418358-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC1 Lentiviral Activation Particles (h)

sc-418358-LAChGene ActivationPuro, Blast, Hygro0
(0)

ORC1 Lentiviral Activation Particles (h2)

sc-418358-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC2 CRISPR Activation Plasmid (h)

sc-402746-ACThGene ActivationPuro, Blast, Hygro0
(0)

ORC2 CRISPR Activation Plasmid (h2)

sc-402746-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC2 Lentiviral Activation Particles (h)

sc-402746-LAChGene ActivationPuro, Blast, Hygro0
(0)

ORC2 Lentiviral Activation Particles (h2)

sc-402746-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC3 CRISPR Activation Plasmid (h)

sc-405473-ACThGene ActivationPuro, Blast, Hygro0
(0)

ORC3 CRISPR Activation Plasmid (h2)

sc-405473-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC3 Lentiviral Activation Particles (h)

sc-405473-LAChGene ActivationPuro, Blast, Hygro0
(0)

ORC3 Lentiviral Activation Particles (h2)

sc-405473-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC4 CRISPR Activation Plasmid (h)

sc-403634-ACThGene ActivationPuro, Blast, Hygro0
(0)

ORC4 CRISPR Activation Plasmid (h2)

sc-403634-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC4 Lentiviral Activation Particles (h)

sc-403634-LAChGene ActivationPuro, Blast, Hygro0
(0)

ORC4 Lentiviral Activation Particles (h2)

sc-403634-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC5 CRISPR Activation Plasmid (h)

sc-409147-ACThGene ActivationPuro, Blast, Hygro0
(0)

ORC5 CRISPR Activation Plasmid (h2)

sc-409147-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC5 Lentiviral Activation Particles (h)

sc-409147-LAChGene ActivationPuro, Blast, Hygro0
(0)

ORC5 Lentiviral Activation Particles (h2)

sc-409147-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC6 CRISPR Activation Plasmid (h)

sc-405854-ACThGene ActivationPuro, Blast, Hygro0
(0)

ORC6 CRISPR Activation Plasmid (h2)

sc-405854-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC6 Lentiviral Activation Particles (h)

sc-405854-LAChGene ActivationPuro, Blast, Hygro0
(0)

ORC6 Lentiviral Activation Particles (h2)

sc-405854-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

ORC siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

ORC1 siRNA (h)

sc-38151hGene SilencingN/A0
(0)

ORC1 shRNA Plasmid (h)

sc-38151-SHhGene SilencingPuromycin0
(0)

ORC1 shRNA (h) Lentiviral Particles

sc-38151-VhGene SilencingPuromycin0
(0)

ORC1 siRNA (m)

sc-38152mGene SilencingN/A0
(0)

ORC1 shRNA Plasmid (m)

sc-38152-SHmGene SilencingPuromycin0
(0)

ORC1 shRNA (m) Lentiviral Particles

sc-38152-VmGene SilencingPuromycin0
(0)

ORC2 siRNA (h)

sc-38153hGene SilencingN/A0
(0)

ORC2 shRNA Plasmid (h)

sc-38153-SHhGene SilencingPuromycin0
(0)

ORC2 shRNA (h) Lentiviral Particles

sc-38153-VhGene SilencingPuromycin0
(0)

ORC2 siRNA (m)

sc-38154mGene SilencingN/A0
(0)

ORC2 shRNA Plasmid (m)

sc-38154-SHmGene SilencingPuromycin0
(0)

ORC2 shRNA (m) Lentiviral Particles

sc-38154-VmGene SilencingPuromycin0
(0)

ORC3 siRNA (h)

sc-38155hGene SilencingN/A
1
(0)

ORC3 shRNA Plasmid (h)

sc-38155-SHhGene SilencingPuromycin
1
(0)

ORC3 shRNA (h) Lentiviral Particles

sc-38155-VhGene SilencingPuromycin
1
(0)

ORC3 siRNA (m)

sc-38156mGene SilencingN/A0
(0)

ORC3 shRNA Plasmid (m)

sc-38156-SHmGene SilencingPuromycin0
(0)

ORC3 shRNA (m) Lentiviral Particles

sc-38156-VmGene SilencingPuromycin0
(0)

ORC4 siRNA (h)

sc-38157hGene SilencingN/A0
(0)

ORC4 shRNA Plasmid (h)

sc-38157-SHhGene SilencingPuromycin0
(0)

ORC4 shRNA (h) Lentiviral Particles

sc-38157-VhGene SilencingPuromycin0
(0)

ORC4 siRNA (m)

sc-38158mGene SilencingN/A
1
(0)

ORC4 shRNA Plasmid (m)

sc-38158-SHmGene SilencingPuromycin
1
(0)

ORC4 shRNA (m) Lentiviral Particles

sc-38158-VmGene SilencingPuromycin
1
(0)

ORC5 siRNA (h)

sc-38159hGene SilencingN/A0
(0)

ORC5 shRNA Plasmid (h)

sc-38159-SHhGene SilencingPuromycin0
(0)

ORC5 shRNA (h) Lentiviral Particles

sc-38159-VhGene SilencingPuromycin0
(0)

ORC5 siRNA (m)

sc-38160mGene SilencingN/A0
(0)

ORC5 shRNA Plasmid (m)

sc-38160-SHmGene SilencingPuromycin0
(0)

ORC5 shRNA (m) Lentiviral Particles

sc-38160-VmGene SilencingPuromycin0
(0)

ORC6 siRNA (h)

sc-38161hGene SilencingN/A0
(0)

ORC6 shRNA Plasmid (h)

sc-38161-SHhGene SilencingPuromycin0
(0)

ORC6 shRNA (h) Lentiviral Particles

sc-38161-VhGene SilencingPuromycin0
(0)

ORC6 siRNA (m)

sc-38162mGene SilencingN/A0
(0)

ORC6 shRNA Plasmid (m)

sc-38162-SHmGene SilencingPuromycin0
(0)

ORC6 shRNA (m) Lentiviral Particles

sc-38162-VmGene SilencingPuromycin0
(0)