ORC1 Antibody (F-10): sc-398734
- ORC1 Antibody (F-10) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 782-861 mapping at the C-terminus of ORC1 of human origin
- ORC1 Antibody (F-10) is recommended for detection of ORC1 of human origin by WB, IP, IF and ELISA
- Anti-ORC1 Antibody (F-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-398734 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ORC1 Antibody (F-10) for WB applications. These reagents are now offered in bundles with ORC1 Antibody (F-10) (see ordering information below).
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ORC1 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ORC1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ORC1 (F-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Origin recognition complex 1 (ORC1) plays a pivotal role in initiating DNA replication, essential for cell division and proliferation. ORC1 monoclonal antibody (F-10) targets proteins primarily located in proliferating cell nuclei, where ORC1 binds to specific replication origins and serves as a scaffold for assembling additional initiation factors. This localization ensures DNA replication occurs at correct genomic sites, maintaining stability. Anti-ORC1 antibody (F-10) recognizes proteins that interact with other ORC subunits (ORC2, ORC3, ORC4, ORC5, and ORC6) to form a core complex vital for G1-S transition in the cell cycle. While ORC1 and ORC2 express at similar levels throughout the cell cycle, only ORC2 remains stably bound to chromatin, highlighting these proteins′ dynamic nature during DNA replication. Proper ORC1 functioning and associated proteins ensure accurate DNA replication, fundamental to cellular health and cancer prevention.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ORC1 Antibody (F-10) | sc-398734 | 200 µg/ml | $316.00 | |||
ORC1 Antibody (F-10): m-IgG Fc BP-HRP Bundle | sc-527805 | 200 µg Ab; 10 µg BP | $354.00 | |||
ORC1 Antibody (F-10): m-IgG1 BP-HRP Bundle | sc-533178 | 200 µg Ab; 20 µg BP | $354.00 | |||
ORC1 Antibody (F-10) X | sc-398734 X | 200 µg/0.1 ml | $316.00 | |||
ORC1 Antibody (F-10) AC | sc-398734 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ORC1 Antibody (F-10) HRP | sc-398734 HRP | 200 µg/ml | $316.00 | |||
ORC1 Antibody (F-10) FITC | sc-398734 FITC | 200 µg/ml | $330.00 | |||
ORC1 Antibody (F-10) PE | sc-398734 PE | 200 µg/ml | $343.00 | |||
ORC1 Antibody (F-10) Alexa Fluor® 488 | sc-398734 AF488 | 200 µg/ml | $357.00 | |||
ORC1 Antibody (F-10) Alexa Fluor® 546 | sc-398734 AF546 | 200 µg/ml | $357.00 | |||
ORC1 Antibody (F-10) Alexa Fluor® 594 | sc-398734 AF594 | 200 µg/ml | $357.00 | |||
ORC1 Antibody (F-10) Alexa Fluor® 647 | sc-398734 AF647 | 200 µg/ml | $357.00 | |||
ORC1 Antibody (F-10) Alexa Fluor® 680 | sc-398734 AF680 | 200 µg/ml | $357.00 | |||
ORC1 Antibody (F-10) Alexa Fluor® 790 | sc-398734 AF790 | 200 µg/ml | $357.00 |