ORC1 Antibody (7F6/1): sc-53390

ORC1 Antibody (7F6/1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ORC1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ORC1 antibody (7F6/1) plays a pivotal role in the initiation of DNA replication, a complex process essential for cell division and proliferation. ORC1 (7F6/1) antibody recognizes a key component of the origin recognition complex (ORC), which binds to specific DNA sequences at replication origins, serving as a scaffold for additional initiation factors. This binding is crucial for forming pre-replication complexes, necessary for proper timing and regulation of DNA replication. ORC1 (7F6/1) monoclonal antibody targets proteins predominantly located in proliferating cell nuclei, including tissues such as testis, where ORC1 is expressed alongside other ORC subunits. While ORC1 and ORC2 maintain similar levels throughout the cell cycle, only ORC2 remains stably associated with chromatin, highlighting these proteins′ dynamic nature during G1-S transition. ORC1 interaction with ORC2, ORC3, ORC4, and ORC5 to form a core complex underscores their importance in ensuring accurate DNA replication and maintaining genomic stability.

The preferred ORC1 antibody is ORC1 Antibody (7A7): sc-23887.