ORC6 Antibody (D-4): sc-390490

ORC6 Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects ORC6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ORC6, a critical component of the origin recognition complex, plays a vital role in the initiation of DNA replication by facilitating the assembly of pre-replication complexes at replication origins. ORC6 is predominantly located in the nucleus of proliferating cells, where ORC6 interacts with other ORC subunits to form a stable core complex essential for the G1-S transition of the cell cycle. Proper functioning of ORC6 is crucial for maintaining genomic stability, as any dysregulation in ORC6 activity can lead to replication stress and contribute to oncogenesis. Additionally, ORC6 undergoes post-translational modifications, such as phosphorylation, which can influence stability and interaction with other proteins, further underscoring ORC6′s importance in cell cycle regulation and DNA replication processes. With an ability to provide insights into the mechanisms of DNA replication and cell cycle control, anti-ORC6 antibody (D-4) is an invaluable tool for researchers studying these fundamental biological processes.

The preferred ORC6 antibody is ORC6 Antibody (3A4): sc-32735.