ORC6 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a tetracyclic diterpene that specifically inhibits DNA polymerase α and δ, leading to the blockage of DNA synthesis, indirectly affecting the function of ORC6 by inhibiting the replication it initiates. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin targets topoisomerase I, preventing DNA relaxation necessary for replication fork progression, thus indirectly affecting ORC6's role in DNA replication initiation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II activity, causing DNA strand breaks and impairing replication processes, indirectly affecting ORC6's role. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone is a topoisomerase II inhibitor that interrupts DNA replication and transcription, indirectly limiting ORC6's replication initiation. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Although primarily a CDK inhibitor, palbociclib can affect cell cycle progression and DNA replication indirectly, potentially altering the activity of the ORC complex. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a CDK inhibitor, which can disrupt the cell cycle and therefore indirectly the initiation of DNA replication where ORC6 is involved. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpene triepoxide that can inhibit the expression of various genes involved in cell cycle regulation and DNA replication, thereby affecting ORC6 function. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin, while primarily a cholesterol-lowering agent, can inhibit DNA synthesis by depleting isoprenoid intermediates necessary for cell cycle progression, indirectly affecting ORC6. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a CDK inhibitor, which may halt cell cycle and thereby indirectly interfere with ORC6's function in replication initiation. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor, and while its direct action is on DNA repair, it can also result in replication stress which indirectly could affect the function of ORC6. | ||||||