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Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways.
See how others have used Olaparib. Click on the entry to view the PubMed entry .
PMID: # 30784586 Munnur, D.|Somers, J.|Skalka, G.|Weston, R.|Jukes-Jones, R.|Bhogadia, M.|Dominguez, C.|Cain, K.|Ahel, I.|Malewicz, M.| et al. 2019. Cell Rep. 26: 2028-2036.e6.
PMID: # 30054449 2018. J. Cell Biol. 217: 3382-3397.
PMID: # 29784019 2018. J. Exp. Clin. Cancer Res. 37: 107.
PMID: # 28069876 Li, J. et al. 2017. Mol. Cancer Ther.
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