Molecular structure of Mitoxantrone, CAS Number: 65271-80-9
Mitoxantrone (CAS 65271-80-9)
See product citations (8)
Alternate Names:
Novantrone; Dihydroxyanthraquinone
Application:
Mitoxantrone is a type II topoisomerase inhibitor
CAS Number:
65271-80-9
Purity:
≥97%
Molecular Weight:
444.48
Molecular Formula:
C22H28N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mitoxantrone is a synthetic compound with a chemical structure designed to intercalate into DNA strands. This intercalation process disrupts DNA replication and transcription, leading to inhibition of cellular proliferation. The biochemical mechanisms of mitoxantrone offer valuable insights for research in fields such as molecular biology, genetics, and biochemistry. Researchers can use mitoxantrone as a tool to investigate the intricacies of DNA replication and transcription, potentially uncovering new aspects of cellular regulation and the maintenance of genomic integrity. Mitoxantrone also inhibits Topoisomerase II.
Mitoxantrone (CAS 65271-80-9) References
- Establishment of a luciferase assay-based screening system: fumitremorgin C selectively inhibits cellular proliferation of immortalized astrocytes expressing an active form of AKT. | Wang, L., et al. 2008. Biochem Biophys Res Commun. 373: 392-6. PMID: 18570889
- Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus. | Kato, N., et al. 2009. Chembiochem. 10: 920-8. PMID: 19226505
- Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene. | Kawahara, H., et al. 2010. Cancer Sci. 101: 1493-500. PMID: 20345483
- Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. | González-Lobato, L., et al. 2010. Eur J Pharmacol. 644: 41-8. PMID: 20655304
- Bioactive metabolites from the mycelia of the basidiomycete Hericium erinaceum. | Lu, QQ., et al. 2014. Nat Prod Res. 28: 1288-92. PMID: 24635196
- Cytotoxic compounds from the marine-derived fungus Aspergillus sp. recovered from the sediments of the Brazilian coast. | Saraiva, NN., et al. 2015. Nat Prod Res. 29: 1545-50. PMID: 25532964
- The Inhibitor Ko143 Is Not Specific for ABCG2. | Weidner, LD., et al. 2015. J Pharmacol Exp Ther. 354: 384-93. PMID: 26148857
- Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators. | Peña-Solórzano, D., et al. 2018. ACS Med Chem Lett. 9: 854-859. PMID: 30128080
- ABCG2 Overexpression Contributes to Pevonedistat Resistance. | Kathawala, RJ., et al. 2020. Cancers (Basel). 12: PMID: 32059437
- Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways. | Yuan, Y., et al. 2020. Front Pharmacol. 11: 238. PMID: 32210820
- Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer. | Liu, K., et al. 2022. Recent Pat Anticancer Drug Discov. 17: 387-395. PMID: 35023460
- Isolation of the side population from neurogenic niches enriches for endothelial cells. | Kalinina, A., et al. 2022. PLoS One. 17: e0250752. PMID: 35045082
- Fumitremorgin C alleviates advanced glycation end products (AGE)-induced chondrocyte inflammation and collagen II and aggrecan degradation through sirtuin-1 (SIRT1)/nuclear factor (NF)-κB/ mitogen-activated protein kinase (MAPK). | Zhou, Y., et al. 2022. Bioengineered. 13: 3867-3876. PMID: 35109750
- Complete genome sequencing of Bacillus subtilis (CWTS 5), a siderophore-producing bacterium triggers antagonistic potential against Ralstonia solanacearum. | Chandwani, S., et al. 2023. J Appl Microbiol. 134: PMID: 37002541
Inhibitor of:
4930547C10Rik, 6030422M02Rik, 9230110F15Rik, AChRα, Adenovirus-2 E1A, AP-2β, ARMCX4, ATAD5, ATR2, AUNIP, B930041F14Rik, BC049762, C1orf85, C1orf93, C6orf167, CCT8L1, Cdc14, CDKN2AIPNL, CELF5, CHMP7, CPN cat, CST9L, Cytokeratin 14, Dclre1c, DDX10, DDX19B, DDX38, DDX42, DDX43, DDX52, DDX59, DEAH-box RNA-dependent NTPase (DHX), DHX32, DLN1, DNA pol β, DNAH5, Elongin B, EVI5L, FAM137B, FAM139A, FAM186A, FIGNL2, FUS/TLS, GEN1, GlnRS, gp210, GPN2, GRSF-1, GTF3A, H2-M10.2, H2-M10.6, H2AL2, hCAP-H, HEATR5B, HEL308, HELIC1, Histone cluster 1 H2AF, Histone cluster 1 H2BP, Histone cluster 2 H2BF, HMG-1L1, HMG-2, HMG-I/HMG-Y, HMGI-C, HMGN3, hnRNP B1, hnRNP D, hnRNP U, HOMEZ, HoxC9, HSP 105, HTH, JAMP, Jaz, KIAA1462, Kinocilin, KRTAP14, KRTAP9-L3, LBA1, Lce1l, LHX4, LOC100040299, LOC388282, LOC643862, LOC644192, LRRC59, Mex67, MTF-2, NAGAT, Ncapd3, NIFK, Nkx-6, NNP-1, Nop5, NTH1, OBFC1, OBFC2B, OFCC1, Olfr572, OTUB2, p91, PAI-RBP1, PCNXL4, PGBD5, Pontin 52, POTE14, POTE8, Psf1, PSG9, PUS1, Ran BP-6, RBM32B, RBMX2, RBMXL3, RBMY1F, REPIN1, Rfp2, Ribosomal Protein L12, Ribosomal Protein L35A, RMI1, RPAC2, Rpp25, RSBN1L, RuvC, RWDD2A, SAPAP3, SCML4, Seh1, sentan, SerRSmt, SKIV2L, SKIV2L2, SLY, Sm, SMF_Hmgxb3, SPIN1, SR-β, SSBP1, SSBP2, SUN3, SUV3, SWAP, SWI5, Syntaxin 16, TAF I p110_TAF I p95, TATDN1, TBCEL, TBPIP, TCEANC, TDE1, TEX11, TEX15, TFIIA, TFIIIB90, TFIIIC35, THAP9, Tomm20l, Top3, Topo II, Topo IIIβ, TRIM34, TSLP, TTL, Twinkle, UBF, UFD1, UIMC1, USF-1, USP24, USP36, WDHD1, Wnt-8b, YTHDF1, ZASC1, ZCCHC7, ZNF14, ZNF140, ZNF154, ZNF254, ZNF266, ZNF275, ZNF28, ZNF283, ZNF436, ZNF510, ZNF670, ZNF676, and ZNF746.Activator of:
4930547C10Rik, Exportin 4, FANCB, FANK1, La/SSB, NAP1L4, Nucleostemin, Nup88, RecQL1, TDP2, and Top1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mitoxantrone, 100 mg | sc-207888 | 100 mg | $279.00 |