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Etoposide (VP-16) (CAS 33419-42-0)

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Alternate Names:
Etoposide (VP-16) is also known as EPE.
Application:
Etoposide (VP-16) is an apoptosis inducer that inhibits DNA synthesis via topoisomerase II inhibition.
CAS Number:
33419-42-0
Purity:
≥99%
Molecular Weight:
588.56
Molecular Formula:
C29H32O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Etoposide (VP-16) is extensively utilized in molecular biology research for its role as a topoisomerase II inhibitor. This compound facilitates the study of DNA replication, transcription, and cell cycle progression by stabilizing the transient DNA double-strand breaks induced by topoisomerase II, thus preventing the religation of these breaks. Research involving Etoposide (VP-16) often focuses on its ability to induce DNA damage and subsequent cellular responses, such as apoptosis and checkpoint activation. Additionally, it is employed in studies examining the mechanisms of chromosomal translocations and gene amplification. Etoposide (VP-16) also plays a role in research aimed at understanding the cellular mechanisms underlying stress responses to DNA damage, which is for insights into the maintenance of genomic stability.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

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Etoposide (VP-16) (CAS 33419-42-0) References

  1. Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma.  |  Arellano-Rodrigo, E., et al. 2003. Eur J Haematol. 70: 219-24. PMID: 12656744
  2. The cancer chemotherapy drug etoposide (VP-16) induces proinflammatory cytokine production and sickness behavior-like symptoms in a mouse model of cancer chemotherapy-related symptoms.  |  Wood, LJ., et al. 2006. Biol Res Nurs. 8: 157-69. PMID: 17003255
  3. Chromosome aberrations induced by etoposide (VP-16) are not random.  |  Maraschin, J., et al. 1990. Int J Cancer. 46: 808-12. PMID: 2228309
  4. Etoposide (VP-16). Retrospective analysis of treatment in 13 dogs with lymphoma.  |  Hohenhaus, AE. and Matus, RE. 1990. J Vet Intern Med. 4: 239-41. PMID: 2262925
  5. Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small-cell lung cancer.  |  Evans, WK., et al. 1985. J Clin Oncol. 3: 65-71. PMID: 2981293
  6. Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26).  |  Haim, N., et al. 1986. Biochem Biophys Res Commun. 135: 215-20. PMID: 3006680
  7. Carboplatin (Paraplatin; JM8) and etoposide (VP-16) as first-line combination therapy for small-cell lung cancer.  |  Smith, IE., et al. 1987. J Clin Oncol. 5: 185-9. PMID: 3027268
  8. Bioavailability and pharmacokinetics of etoposide (VP-16).  |  Smyth, RD., et al. 1985. Semin Oncol. 12: 48-51. PMID: 3975657
  9. Etoposide: twenty years later.  |  Hainsworth, JD. and Greco, FA. 1995. Ann Oncol. 6: 325-41. PMID: 7619747
  10. Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle.  |  Fearnhead, HO., et al. 1994. Biochem Pharmacol. 48: 1073-9. PMID: 7945400
  11. High frequency of etoposide (VP-16)-related secondary leukemia in children with non-Hodgkin's lymphoma.  |  Sugita, K., et al. 1993. Am J Pediatr Hematol Oncol. 15: 99-104. PMID: 8447565
  12. Review of current clinical experience with prolonged (oral) etoposide in cancer treatment.  |  de Jong, RS., et al. 1995. Anticancer Res. 15: 2319-30. PMID: 8572646
  13. Enhancement of etoposide (VP-16) cytotoxicity by enzymatic and photodynamically induced oxidative stress.  |  Gantchev, TG. and Hunting, DJ. 1997. Anticancer Drugs. 8: 164-73. PMID: 9073312
  14. Risk of secondary leukemia after treatment with etoposide (VP-16) for Langerhans' cell histiocytosis in Italian and Austrian-German populations.  |  Haupt, R., et al. 1997. Int J Cancer. 71: 9-13. PMID: 9096658
  15. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.  |  Lorico, A., et al. 1997. Cancer Res. 57: 5238-42. PMID: 9393741

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Etoposide (VP-16), 10 mg

sc-3512B
10 mg
$51.00

Etoposide (VP-16), 100 mg

sc-3512
100 mg
$231.00

Etoposide (VP-16), 500 mg

sc-3512A
500 mg
$523.00