Aphidicolin CAS: 38966-21-1
MF: C20H34O4
MW: 338.48

Aphidicolin (CAS 38966-21-1)

Aphidicolin | CAS 38966-21-1 is rated 5.0 out of 5 by 3.
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Alternate Names: Aphidicolin is also known as APC.
Application: Aphidicolin is a novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes.
CAS Number: 38966-21-1
Purity: ≥98%
Molecular Weight: 338.48
Molecular Formula: C20H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Aphidicolin is a diterpene fungal metabolite that blocks the cell cycle at early S-phase. In addition, Aphidicolin is a tetracyclic diterpene antibiotic with antiviral and antimitotic properties. Aphidicolin was first isolated from Cephelosporium aphidicola. Aphidicolin is a specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Aphidicolin is useful for cell synchronization. Aphidicolin blocks the cell cycle at early S phase. Aphidicolin prolongs the half life of DNA methyltransferase. Aphidicolin acts synergistically with vincristine and doxorubicin. In medicine, Aphidicolin may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells. Aphidicolin is also known as APC, ICI 69653, ICI-69653, ICI69653, and (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol.


References

1. Levenson, V. and Hamlin, J.L., Nucleic Acids Res. 21, 3997, (1993)
2. O′Dwyer, P.J. et al., Cancer Res. 54, 724, (1994)
3. Ikegami, S. et al., Nature 275, 458, (1978)
4. Schimke, R.T. et al. Philos. Trans. R. Soc. London B Biol. Sci. 345, 311, (1994)
5. Urbani, L. et al., Exp. Cell. Res. 219, 159, (1995)
6. Borner, M.M. et al., Cancer Res. 55, 2122, (1995)
7. Poluha, W. et al., Oncogene 10, 185, (1995)
8. Fan, X. and Price, C.M., Mol. Biol. Cell 8, 2145, (1997)
9. Suetake, I. et al., Cell Struct. Funct. 23, 137, (1998)
10. Michaelis, M. et al., Anticancer Drugs 11, 479, (2000)
11. Tedeschi, B. et al.; Mutat. Res. 546, 55, (2004)
12. S. Spadari, et al., TIBS 7, 29, (1982)

Usage :
Aphidicolin is soluble in DMSO (50 mg/ml) and Methanol (10 mg/ml) purged in inert gas.
Physical State :
Solid
Solubility :
Soluble in ethanol (1 mg/ml,stable at least a week at 4°C.), DMSO (10 mg/ml,stable at least six weeks at -20°C.), and methanol (10 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
227-233° C (lit.)
Boiling Point :
457.85-557.8° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α27D +12, c = 1 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
PB9185000
PubChem CID :
457964
Merck Index :
14: 727
MDL Number :
MFCD00083214
Beilstein Registry :
4689958

Download SDS (MSDS)

Certificate of Analysis

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Aphidicolin (CAS 38966-21-1)  Product Citations

See how others have used Aphidicolin (CAS 38966-21-1). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 30122350  Zhang, P. et al. 2018. Cell.

PMID: # 30006243  Luczak, MW.|Zhitkovich, A.| et al. 2018. Toxicol. Appl. Pharmacol. 355: 238-246.

PMID: # 30449723  Nojima, T.|Tellier, M.|Foxwell, J.|Ribeiro de Almeida, C.|Tan-Wong, SM.|Dhir, S.|Dujardin, G.|Dhir, A.|Murphy, S.|Proudfoot, NJ.| et al. 2018. Mol. Cell. 72: 970-984.e7.

PMID: # 28463988  Calton, CM.|Bronnimann, MP.|Manson, AR.|Li, S.|Chapman, JA.|Suarez-Berumen, M.|Williamson, TR.|Molugu, SK.|Bernal, RA.|Campos, SK.| et al. 2017. PLoS Pathog. 13: e1006200.

PMID: # 27534509  Wang, Y. et al. 2016. Glia. 64: 2154-2165.

PMID: # 27636097  Lewis, CW. et al. 2016. Cell Cycle. 15: 3131-3145.

PMID: # 26755699  Li, J. et al. 2016. Development (Cambridge, England). 143: 670-81.

PMID: # 12684394  Huron, DR. et al. 2003. Clin Cancer Res. 4: 1267-73.

PMID: # 11309295  Huang, S. et al. 2001. Cancer Res. 61: 3373-3381.

PMID: # 7474100  Re, F. et al. 1995. J. Virol. 11: 6859-64.

Citations 1 to 10 of 11 total

What is the expected appearance?

Asked by: chemicalsmg
Thank you for your question. Aphidicolin: sc-201535 is expected to be a white to off-white solid
Answered by: Chemical Support 3
Date published: 2017-02-24

How long would you recommend stock solutions be stored at -20ºC?

Asked by: chemicalsmg
Thank you for your question. Aphidicolin: sc-201535 stock solutions should be stable for up to 3 months if stored at -20ºC.
Answered by: Chemical Support 3
Date published: 2017-02-24
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Rated 5 out of 5 by from quick service fast delivery, great product for our research. Highly recommend it
Date published: 2020-01-02
Rated 5 out of 5 by from We use this chemical often for cell culture We use this chemical often for cell culture and has good quality.
Date published: 2015-10-12
Rated 5 out of 5 by from Huron Huron, et. al. (PubMed ID 12684394) used aphidicolin to synchronize K562 cells to the G1-S boundary (5 M concentration in media for 24 hours) prior to treatment with PD166326 or vehicle. -SCBT Publication Review
Date published: 2015-04-09
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