Date published: 2025-11-27

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Flavopiridol (CAS 146426-40-6)

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Alternate Names:
Alvocidib
Application:
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs
CAS Number:
146426-40-6
Purity:
≥98%
Molecular Weight:
401.84
Molecular Formula:
C21H20ClNO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Flavopiridol is a synthetic flavone compound that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses expression of cyclin D1 and D3, interrupting the central role of Cdks in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9.


Flavopiridol (CAS 146426-40-6) References

  1. Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors.  |  Sekine, C., et al. 2008. J Immunol. 180: 1954-61. PMID: 18209094
  2. Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection.  |  Zhang, C., et al. 2019. mSystems. 4: PMID: 31822599
  3. Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.  |  Ibrahim, N., et al. 2020. Eur J Med Chem. 199: 112355. PMID: 32402934
  4. Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models.  |  Pinto, N., et al. 2020. PLoS One. 15: e0239315. PMID: 32970704
  5. Development and characterization of a novel flavopiridol formulation for treatment of acute myeloid leukemia.  |  Chen, KTJ., et al. 2021. J Control Release. 333: 246-257. PMID: 33798663
  6. Flavopiridol (Alvocidib), a Cyclin-dependent Kinases (CDKs) Inhibitor, Found Synergy Effects with Niclosamide in Cutaneous T-cell Lymphoma.  |  Zhang, XH., et al. 2021. J Clin Haematol. 2: 48-61. PMID: 34223559
  7. Therapeutic Potential of the Cyclin-Dependent Kinase Inhibitor Flavopiridol on c-Myc Overexpressing Esophageal Cancer.  |  Hassan, MS., et al. 2021. Front Pharmacol. 12: 746385. PMID: 34621175
  8. Flavopiridol Mitigates the Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Targeting Cyclin-Dependent Kinase 9.  |  Jia, Q., et al. 2022. Cardiovasc Drugs Ther.. PMID: 35088192
  9. Intra-articular injection of flavopiridol-loaded microparticles for treatment of post-traumatic osteoarthritis.  |  Sangsuwan, R., et al. 2022. Acta Biomater. 149: 347-358. PMID: 35779774
  10. Flavopiridol Protects against Fungal Keratitis due to Aspergillus fumigatus by Alleviating Inflammation through the Promotion of Autophagy.  |  Gu, L., et al. 2022. ACS Infect Dis. 8: 2362-2373. PMID: 36283079
  11. Analytical Quality-by-Design-Based Systematic Optimization of RP-HPLC Method Conditions to Analyze Simultaneously Chloroquine Phosphate and Flavopiridol in Stress-Induced Combined Drug Solution and Pharmaceutical Emulsions.  |  Pawde, DM., et al. 2022. J Chromatogr Sci.. PMID: 36355561
  12. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.  |  De Azevedo, WF., et al. 1996. Proc Natl Acad Sci U S A. 93: 2735-40. PMID: 8610110
  13. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.  |  Patel, V., et al. 1998. J Clin Invest. 102: 1674-81. PMID: 9802881

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Flavopiridol, 5 mg

sc-202157
5 mg
$78.00

Flavopiridol, 25 mg

sc-202157A
25 mg
$254.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-202157, is provided as a yellow solid. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2024-07-13

What is the specific solubility of this compound? I would like to use the data to make stock solutions.

Asked by: two2igm05
Thank you for your question. Flavopiridol, sc-202157, is soluble in DMSO at 15 mg/mL (37.32 mM), Ethanol at 8 mg/mL (19.9 mM), and Water at <1 mg/mL (<1 mM).
Answered by: TechService7
Date published: 2019-08-01
  • y_2025, m_10, d_29, h_4CST
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Rated 5 out of 5 by from Good for controlI bought this item for my Alzheimer's disease research and used as a positive control to block neorotoxicity assay, it works well for the control, and seems pretty stable in DMSO solution
Date published: 2018-02-16
Rated 5 out of 5 by from Satisfied with productSatisfied with product.
Date published: 2015-10-07
Rated 5 out of 5 by from SongSong, Y. et al. (PubMed 25528169) found Flavopiridol, a potent inhibitor of cyclin-dependent kinases, in conjunction with rev-caspases-3, resulted in a significant synergistic cell killing, significant tumor growth suppression and extended survival of mice bearing OVCAR3 cells. -SCBT Publication Review
Date published: 2015-01-25
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Flavopiridol is rated 5.0 out of 5 by 3.
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