HNF-6 Inhibitors
HNF-6 inhibitors, short for Hepatocyte Nuclear Factor 6 inhibitors, belong to a class of chemical compounds designed to modulate the activity of a specific transcription factor called Hepatocyte Nuclear Factor 6 (HNF-6). Transcription factors are proteins that play a crucial role in gene regulation, controlling the expression of genes by binding to their regulatory regions. HNF-6 is particularly significant in the field of molecular biology and genetics, as it is involved in the regulation of various genes related to organ development, particularly in the liver, pancreas, and intestines. HNF-6 inhibitors are designed to interfere with the normal function of HNF-6, either by preventing its binding to DNA or by modifying its activity, ultimately leading to changes in gene expression patterns.
The development of HNF-6 inhibitors has been driven by the desire to gain a deeper understanding of the molecular mechanisms underlying organ development and function. By selectively targeting HNF-6, researchers can investigate how this transcription factor influences the expression of specific genes and, consequently, the development and maintenance of vital organs. Additionally, these inhibitors may have potential applications beyond basic research, as they could serve as tools for studying gene regulation in the context of various diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound may inhibit DNA methylation, potentially leading to changes in the chromatin structure and affecting the binding of transcription factors like HNF-6 to DNA. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can alter the acetylation state of histones, potentially influencing the accessibility of the HNF-6 binding sites on DNA. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is known to inhibit DNA methyltransferases, possibly leading to demethylation of HNF-6 target gene promoters and a subsequent reduction in HNF-6-mediated transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been reported to modulate various signaling pathways and might affect HNF-6 expression indirectly through these pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to modulate several signaling pathways and could potentially influence HNF-6 expression indirectly. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
This compound has been shown to influence epigenetic modifications and could potentially alter HNF-6 expression through changes in DNA methylation or histone acetylation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit aldehyde dehydrogenase, and it might indirectly influence HNF-6 expression by affecting metabolic processes within the cell. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a known tyrosine kinase inhibitor and has been shown to have epigenetic modulating activities, which could potentially impact HNF-6 expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can influence various signaling pathways and could potentially have an indirect effect on HNF-6 expression. | ||||||
Diallyl sulfide | 592-88-1 | sc-204718 sc-204718A | 25 g 100 g | $41.00 $104.00 | 3 | |
Diallyl sulfide has been shown to have effects on phase II detoxifying enzymes and could potentially influence HNF-6 expression through its impact on metabolic processes. | ||||||